Elastic softening of Ti alloys by plastic deformation for safer and more durable bone implants. This project will explore a critical factor that will form the basis of improving the biomechanical compatibility of titanium alloys for human bone implants. The outcomes will be a major step in optimising the design and development of human bone implants that will last a lifetime, avoiding the agony and risk associated with implant failure.
Biodegradable magnesium alloy scaffolds for bone tissue engineering. This project aims to develop a class of porous, biocompatible, biofunctional and biodegradable magnesium alloy scaffolds with designed pore architecture and mechanical properties mimicking those of natural bone for tissue engineering applications. These magnesium alloy scaffolds will be biocompatible, able to bear loads, and will be gradually replaced by natural bone. The outcomes are expected to benefit the ageing population a ....Biodegradable magnesium alloy scaffolds for bone tissue engineering. This project aims to develop a class of porous, biocompatible, biofunctional and biodegradable magnesium alloy scaffolds with designed pore architecture and mechanical properties mimicking those of natural bone for tissue engineering applications. These magnesium alloy scaffolds will be biocompatible, able to bear loads, and will be gradually replaced by natural bone. The outcomes are expected to benefit the ageing population and people with bone abnormalities.Read moreRead less
Highly ordered and tunable extracellular DNA micro- and nanopatterns for investigating the attachment mechanisms of pseudomonas aeruginosa to surfaces. Preventing infectious bacteria from colonising artificial surfaces is a major scientific challenge. New engineered surfaces will be designed to better understand how the important pathogen Pseudomonas aeruginosa sticks to surfaces, facilitating new ways of reducing infections acquired from the surface of, for example, medical devices.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100012
Funder
Australian Research Council
Funding Amount
$890,000.00
Summary
Dual Column-Focused Ion Beam/Scanning Electron Microscope facility for Queensland. Dual column focused ion beam/scanning electron microscope facility: This facility will precisely cut specimens and surfaces that can be imaged in a variety of ways, including crystallographic and elemental space, of particular use for physical scientists, as well as biological specimens. This instrument will provide information at resolutions between optical and transmission electron microscopy, images that will ....Dual Column-Focused Ion Beam/Scanning Electron Microscope facility for Queensland. Dual column focused ion beam/scanning electron microscope facility: This facility will precisely cut specimens and surfaces that can be imaged in a variety of ways, including crystallographic and elemental space, of particular use for physical scientists, as well as biological specimens. This instrument will provide information at resolutions between optical and transmission electron microscopy, images that will effectively provide the biologist with the ability to develop the complete correlative picture of organelles and cells. The instrument will also provide a much needed resource for researchers across disciplines such as physics, chemistry, biology, geology and engineering.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0883021
Funder
Australian Research Council
Funding Amount
$350,000.00
Summary
Advanced Surface Characterisation Facility. This proposal underpins a major expansion of surface characterisation resources at La Trobe University, one of Australia's leading providers in this field, and builds associated research programs and collaborations, in particular, with Monash University and Deakin University. New opportunities will be provided for hands-on training in state-of-the-art surface characterisation for postgraduates in fields such as physics, chemistry, nanotechnology, mater ....Advanced Surface Characterisation Facility. This proposal underpins a major expansion of surface characterisation resources at La Trobe University, one of Australia's leading providers in this field, and builds associated research programs and collaborations, in particular, with Monash University and Deakin University. New opportunities will be provided for hands-on training in state-of-the-art surface characterisation for postgraduates in fields such as physics, chemistry, nanotechnology, materials science and engineering. The Australian community will benefit through internationally significant research outcomes leading to, for example, enhanced medical testing technologies, biocompatible medical appliances, better waste water treatment processes, and new battery technologies.Read moreRead less
Titanium Alloy Scaffolds for Osseointegration Implant Materials. Australians' life expectancies are among the highest in the world. Degeneration of load bearing bones in the elderly of age 65 and over often requires the inception of biomaterial implants. For the hip and knee replacements alone, there are over 52,000 operations performed in Australia each year at an estimated cost of over $500 million. The success of these procedures depends on the implant biomaterials. The outcomes of this proje ....Titanium Alloy Scaffolds for Osseointegration Implant Materials. Australians' life expectancies are among the highest in the world. Degeneration of load bearing bones in the elderly of age 65 and over often requires the inception of biomaterial implants. For the hip and knee replacements alone, there are over 52,000 operations performed in Australia each year at an estimated cost of over $500 million. The success of these procedures depends on the implant biomaterials. The outcomes of this project are a new category of porous bone implant materials for load bearing applications.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE120100139
Funder
Australian Research Council
Funding Amount
$350,000.00
Summary
A Hot Isostatic Press (HIP) for aerospace and biomedical component processing. This facility will provide a hot isostatic press of sufficiently large capacity to maximise production efficiencies in aerospace and biomedical applications through net shape manufacturing. The facility will be able to process small components or prototypes which will behave in a manner similar to larger scale components.
A novel approach to the design and fabrication of biomimetic and biocompatible Ti-Ta implants by additive manufacturing. A large number of the Australian population suffer various types of bone issues arising from either age-related degenerative bone problems or injuries from accidents, sports and other activities. As the number of joint replacements performed in Australia increases, it is important to reduce the rate of implant failure. This project aims to address this critical issue by combin ....A novel approach to the design and fabrication of biomimetic and biocompatible Ti-Ta implants by additive manufacturing. A large number of the Australian population suffer various types of bone issues arising from either age-related degenerative bone problems or injuries from accidents, sports and other activities. As the number of joint replacements performed in Australia increases, it is important to reduce the rate of implant failure. This project aims to address this critical issue by combining unique multi-scale structural design, alloy development, 3D printing, modelling and tissue engineering to develop bone-like biomimetic titanium implants with superior structural, mechanical and biological compatibility with bone. The outcomes aim to contribute to both healthcare and manufacturing industries, as well as improving the quality of life for Australians.Read moreRead less
Novel manufacturing methods for tissue engineering scaffolds. Novel methods of manufacturing biodegradable polymer scaffolds around which new tissue can be grown within the human body will be developed. Surfactant - polymer assemblies will be used to produce highly porous scaffolds of tunable pore size and connectivity, shape and strength. The results will create a new avenue for systematic investigations into the effects of scaffold structure on tissue growth. This research will lead to the dev ....Novel manufacturing methods for tissue engineering scaffolds. Novel methods of manufacturing biodegradable polymer scaffolds around which new tissue can be grown within the human body will be developed. Surfactant - polymer assemblies will be used to produce highly porous scaffolds of tunable pore size and connectivity, shape and strength. The results will create a new avenue for systematic investigations into the effects of scaffold structure on tissue growth. This research will lead to the development of reliable, well-controlled manufacturing techniques for tissue engineering scaffolds, revolutionising current scaffold manufacturing practices. It will enhance existing collaborations between the University of Melbourne and the Bernard O'Brien Institute of Microsurgery.Read moreRead less
Special Research Initiatives - Grant ID: SR0354588
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
Integrated Nanoscale Biosystems Network (INBN). The INBN will integrate high-priority research, already identified by the ARC, in materials nanoscience and engineering with nanoscale biology. The INBN will provide the means to consolidate world-class multidisciplinary Australian research groups in existing Centres of Excellence, including several Federation Fellows, into a nanobiotechnology focus. The significant outcomes of INBN are the critical mass of outstanding researchers in the nanobiosci ....Integrated Nanoscale Biosystems Network (INBN). The INBN will integrate high-priority research, already identified by the ARC, in materials nanoscience and engineering with nanoscale biology. The INBN will provide the means to consolidate world-class multidisciplinary Australian research groups in existing Centres of Excellence, including several Federation Fellows, into a nanobiotechnology focus. The significant outcomes of INBN are the critical mass of outstanding researchers in the nanobiosciences, facilitation of innovative research to produce novel intellectual property and provision of pathways into collaborative research with international scientists and industry, and the training and development of the next generation scientists for this emerging discipline.
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