Excitatory neuropeptides from nematode parasites of sheep. Internal parasites cause major disease and economic loss in Australian agricultural industries. Control, usually achieved with drugs, is now compromised by drug resistance and new remedies are required. Results of recent DNA sequencing projects have allowed us to predict the presence of neuropeptides in the worms of sheep. The aim of this project is to elucidate the steps in the action of these peptides, in particular, those that cause m ....Excitatory neuropeptides from nematode parasites of sheep. Internal parasites cause major disease and economic loss in Australian agricultural industries. Control, usually achieved with drugs, is now compromised by drug resistance and new remedies are required. Results of recent DNA sequencing projects have allowed us to predict the presence of neuropeptides in the worms of sheep. The aim of this project is to elucidate the steps in the action of these peptides, in particular, those that cause muscle contraction. By understanding the action of these peptides we hope to identify targets against which new drugs for parasite control can be developed.Read moreRead less
Development of a topical treatment to replace surgical mulesing in sheep. 10,800 farms in Australia are sheep farms and a further 30,000 have sheep. Exports of wool earn over $2 billion annually. The animal rights campaign to ban mulesing has forced the industry to outlaw mulesing by 2010. Mulesing is largely confined to Australian Merino sheep and requires Australian research. If practical alternatives are not found costs will rise compromising the economic viability of many sheep farms. C ....Development of a topical treatment to replace surgical mulesing in sheep. 10,800 farms in Australia are sheep farms and a further 30,000 have sheep. Exports of wool earn over $2 billion annually. The animal rights campaign to ban mulesing has forced the industry to outlaw mulesing by 2010. Mulesing is largely confined to Australian Merino sheep and requires Australian research. If practical alternatives are not found costs will rise compromising the economic viability of many sheep farms. Chemical use on the breech will increase causing environmental contamination. A simple topical alternative to mulesing will allow farmers to economically manage flies and satisfy welfare imperatives. This will support rural communities and sustain Australia's export income from wool.Read moreRead less
Determining the impact of protozoan pathogens and strongyle worms on prime lamb production. This research will benefit wool and prime lamb industries nation-wide as sheep scouring is prevalent in high-rainfall areas across Australia. Data generated from the project will be used to educate farmers and reduce the financial burden of sheep scouring. This project will also enhance Australia's reputation in the disease management sector and will result in reduced risk to public health due to a better ....Determining the impact of protozoan pathogens and strongyle worms on prime lamb production. This research will benefit wool and prime lamb industries nation-wide as sheep scouring is prevalent in high-rainfall areas across Australia. Data generated from the project will be used to educate farmers and reduce the financial burden of sheep scouring. This project will also enhance Australia's reputation in the disease management sector and will result in reduced risk to public health due to a better understanding and management of zoonotic parasite and microbacterial contamination of carcasses and water catchments.Read moreRead less
Development of a proto-type vaccine against gastrointestinal nematode larvae. Gastrointestinal parasites are the major cause of production losses in the Australian sheep and wool industries. Drug treatment is predominantly used to control infections but drug resistance has reached critical levels and is threatening the viability of sheep production in many rural areas. In collaboration with an international Animal Health company, we aim to develop vaccines against these parasites and provide a c ....Development of a proto-type vaccine against gastrointestinal nematode larvae. Gastrointestinal parasites are the major cause of production losses in the Australian sheep and wool industries. Drug treatment is predominantly used to control infections but drug resistance has reached critical levels and is threatening the viability of sheep production in many rural areas. In collaboration with an international Animal Health company, we aim to develop vaccines against these parasites and provide a clean, non-toxic alternative to drug treatment. The groundbreaking research involved in this project will also keep Australian animal scientists at the forefront of vaccine research and increase their capacity to attract further support from Industry.Read moreRead less
In vitro prediction tests of fertility of frozen semen of sheep and cattle. Variation in fertility after artificial insemination (AI) of frozen semen is high and leads to economic loss. Routine assessment of the quality of frozen semen relies on crude, simple tests of motility and morphology of sperm. More sophisticated sperm ultrastructural and function tests have recently been developed, but it is not known how these tests relate to fertility in the field. In this project we will test a ran ....In vitro prediction tests of fertility of frozen semen of sheep and cattle. Variation in fertility after artificial insemination (AI) of frozen semen is high and leads to economic loss. Routine assessment of the quality of frozen semen relies on crude, simple tests of motility and morphology of sperm. More sophisticated sperm ultrastructural and function tests have recently been developed, but it is not known how these tests relate to fertility in the field. In this project we will test a range of in vitro methods of assessment of motility and morphology of sperm and compare them with fertility of frozen semen samples after AI, leading to more objective methods of semen analysis.Read moreRead less
STRUCTURAL CHARACTERIZATION OF ACTIVE CONSTITUENTS IN PLANT EXTRACTS WITH POTENTIAL FOR THE CONTROL OF OVINE LICE AND PARASITIC WORMS. The control of lice and parasitic worms are two of the major problems currently confronting the Australian sheep industry. Several plant extracts utilized in traditional medicine have shown a remarkable efficacy in the control of these pests in humans. This project will investigate the sheep lousicidal and anthelmintic activity of a number of plants, and identif ....STRUCTURAL CHARACTERIZATION OF ACTIVE CONSTITUENTS IN PLANT EXTRACTS WITH POTENTIAL FOR THE CONTROL OF OVINE LICE AND PARASITIC WORMS. The control of lice and parasitic worms are two of the major problems currently confronting the Australian sheep industry. Several plant extracts utilized in traditional medicine have shown a remarkable efficacy in the control of these pests in humans. This project will investigate the sheep lousicidal and anthelmintic activity of a number of plants, and identify and chemically characterize the active constituents. This research will lead to the production of more environmentally friendly pest control methods and overcome problems of insecticidal resistance currently facing the industry.Read moreRead less
Modelling the structure of Australian wool auction prices. Australian wool auction ($3.5-4 billions per year) is an on-going process. The prices paid in this auction market are used by the Australian production and service sectors to identify the quality preferences the international retail markets and the intermediate processors. The proposed research will optimise the information that can be extracted and used by these sectors in the production and distribution of the raw wool clip. A two- ....Modelling the structure of Australian wool auction prices. Australian wool auction ($3.5-4 billions per year) is an on-going process. The prices paid in this auction market are used by the Australian production and service sectors to identify the quality preferences the international retail markets and the intermediate processors. The proposed research will optimise the information that can be extracted and used by these sectors in the production and distribution of the raw wool clip. A two-stages algorithm in tree-based regression will be developed. The project will provide a challenge environment to train a Ph.D. student in agriculture modelling and optimisation.Read moreRead less
Bayesian methodology for analysis of genome data with focus on the livestock industry. The aim is to develop statistical methods for the design and analysis of genome data with focus on the special needs of the livestock industry. This will significantly contribute to profitability, quality, genetic improvement and genetic knowledge in a key national industry, improve Australia's international and national profile in the key research area of bioinformatics, and encourage optimisation of current ....Bayesian methodology for analysis of genome data with focus on the livestock industry. The aim is to develop statistical methods for the design and analysis of genome data with focus on the special needs of the livestock industry. This will significantly contribute to profitability, quality, genetic improvement and genetic knowledge in a key national industry, improve Australia's international and national profile in the key research area of bioinformatics, and encourage optimisation of current information. Outcomes include a toolkit of applicable statistical methods, statistically valid algorithms, marketable methods for gene discovery, technology transfer, training and publications.Read moreRead less
The Properties and Processing Performance of Ultrasonically Cleaned Wool Fibres. Australian wool production is a $2.5 billion export industry, and about 70% of Australian wool is exported to China for further processing. Scouring or wool cleaning is the first critical step in the processing chain, which has come under increasing pressure to reduce water and energy consumption and effluent discharge. Assisting leading wool processors in the research and development of the latest wool processing t ....The Properties and Processing Performance of Ultrasonically Cleaned Wool Fibres. Australian wool production is a $2.5 billion export industry, and about 70% of Australian wool is exported to China for further processing. Scouring or wool cleaning is the first critical step in the processing chain, which has come under increasing pressure to reduce water and energy consumption and effluent discharge. Assisting leading wool processors in the research and development of the latest wool processing technologies is of direct benefit to the wool production industry in Australia.Read moreRead less
Investigation of the immunological properties of a novel adjuvant in sheep. The induction of strong immune responses without side effects is a highly desirable goal in vaccine R&D. The recently developed adjuvant DCtag utilises unique properties of dendritic cells to boost both cellular and humoral immune responses without tissue damage. This project will identify the mechanisms of immune induction of DCtag using unique properties of our sheep cannulation model. This will allow further optimisat ....Investigation of the immunological properties of a novel adjuvant in sheep. The induction of strong immune responses without side effects is a highly desirable goal in vaccine R&D. The recently developed adjuvant DCtag utilises unique properties of dendritic cells to boost both cellular and humoral immune responses without tissue damage. This project will identify the mechanisms of immune induction of DCtag using unique properties of our sheep cannulation model. This will allow further optimisation of DCtag adjuvanticity in sheep, which will then be applied to the delivery of a prototype peptide based vaccine against foot and mouth disease virus, a veterinary disease of global importance, hereby increasing Australia's leadership in biotechnology.Read moreRead less