Prospective Evaluation Of A Model To Predict Outcomes Following Endovascular Aortic Aneurysm Repair
Funder
National Health and Medical Research Council
Funding Amount
$1,098,901.00
Summary
Once present, abdominal aortic aneurysms tend to enlarge over time resulting in an increased risk of death if they rupture. Endovascular aneurysm repair may be used to fix the aneurysm but this procedure can result in complications over time. We developed a model that uses pre-operative information to predict the chance of an individual having poor results.This study aims to assess whether the model is a good predictor of outcomes and whether extra information will improve its accuracy.
Refining Methods For Obtaining, Synthesising And Interpreting Research Evidence In Surgery
Funder
National Health and Medical Research Council
Funding Amount
$314,312.00
Summary
Research evidence plays a crucial role in improving clinical care. However the main forms of evidence and the tools that facilitate evidence use - namely randomised controlled trials (RCT) and structured systematic reviews of existing research - have had limited application in surgery for a variety of reasons. This project aims to promote the use of research evidence in surgical decision making by developing tools tailored to the predominance of non-RCTs in surgery and surgeons' information need ....Research evidence plays a crucial role in improving clinical care. However the main forms of evidence and the tools that facilitate evidence use - namely randomised controlled trials (RCT) and structured systematic reviews of existing research - have had limited application in surgery for a variety of reasons. This project aims to promote the use of research evidence in surgical decision making by developing tools tailored to the predominance of non-RCTs in surgery and surgeons' information needs.Read moreRead less
Improved Ex-vivo Culture Of Keratinocytes For Clinical Applications
Funder
National Health and Medical Research Council
Funding Amount
$275,203.00
Summary
Skin cells grown for clinical applications currently require animal-derived cells and-or non-defined products for their expansion in the laboratory; these reagents can potentially infect patients who receive these therapies. This project will identify the essential components provided by these reagents and develop a fully synthetic and defined culture system. This improvement will provide safer, cost-effective grafts and cell-based therapies that will benefit patients suffering burns and wounds.
Clinical Outcomes Following Lumbar Spine Surgery Using The DIAM Non-fusion Interspinous Implant
Funder
National Health and Medical Research Council
Funding Amount
$72,343.00
Summary
This investigation will focus on a single minimally-invasive surgical intervention used in the treatment of disorders of the lumbar spine. The Device for Intervertebral Assisted Motion (DIAM) is a novel system for stabilizing the disc and joints of the low back which is promoted over fusion for improving stability while restoring normal vertebral alignment. This new device has limited research evaluation of efficacy and will be examined with the aim of providing clinical guidelines for its use.
Discovery Early Career Researcher Award - Grant ID: DE120100402
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
The effectiveness of intervention in communication and safety climate in the operating room. This project will evaluate the effectiveness of an educational intervention on teamwork behaviours in surgery. It will deliver beneficial effects for communication in service delivery, safety and patient care in support of health care in high risk environments.
Pre-hospital Antifibrinolytics For Traumatic Coagulopathy And Haemorrhage (The PATCH Study)
Funder
National Health and Medical Research Council
Funding Amount
$1,668,152.00
Summary
About 2500 Australians die annually from severe injuries. Bleeding is exacerbated by early-onset clotting defects, which are associated with high mortality. The antifibrinolytic agent tranexamic acid has been shown to reduce mortality due to bleeding when given in hospital in less developed trauma systems, but its usefulness as a pre-emptive strike at the scene of injury in developed systems is unknown. Building on our prehospital clinical trials expertise, we will conduct a trial to assess its ....About 2500 Australians die annually from severe injuries. Bleeding is exacerbated by early-onset clotting defects, which are associated with high mortality. The antifibrinolytic agent tranexamic acid has been shown to reduce mortality due to bleeding when given in hospital in less developed trauma systems, but its usefulness as a pre-emptive strike at the scene of injury in developed systems is unknown. Building on our prehospital clinical trials expertise, we will conduct a trial to assess its effect on 6-month death and disability.Read moreRead less