Antibiotic Treatment Of Male Partners To Reduce Recurrence Of Bacterial Vaginosis In Women: A Randomised Double-blind Controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$636,674.00
Summary
Bacterial vaginosis (BV) is the most common vaginal infection in women. Healthy bacteria are lost and replaced by bacteria that cause unpleasant discharge and odour. BV puts women at increased risk of sexually transmitted infections, HIV, miscarriage and preterm delivery. Over 50% of women given antibiotics get BV back again. Studies suggest these bacteria are being sexually transmitted. We are conducting a trial of antibiotic treatment of women and their male partners to improve BV cure.
A Randomised Controlled Trial (RCT) Of Azithromycin Versus Doxycycline For The Treatment Of Rectal Chlamydia Infection In Men Who Have Sex With Men.
Funder
National Health and Medical Research Council
Funding Amount
$797,906.00
Summary
Rectal chlamydia is very common among gay men; it can exist for long periods without symptoms leading to ongoing transmission. Azithromycin (1 gram single dose) or 7 days doxycycline (100mg twice daily) are the two recommended treatments globally. But, there is concern about rectal chlamydia treatment with reports of up to 22% failure following azithromycin. We will conduct a randomised trial to compare these treatments for rectal chlamydia and determine which drug works better.
Use Of Molecular Resistance Assays To Provide Alterative Oral Treatment Strategies For Gonorrhoea In Indigenous And Other High-risk Populations; A Randomised Cluster Trial
Funder
National Health and Medical Research Council
Funding Amount
$828,671.00
Summary
Gonorrhoea has now developed resistance to almost all antibiotics that have been used to treat it. In this study, we will investigate a new treatment approach that selects antibiotics on a patient-by-patient basis. We will use new molecular assays to first test if a gonorrhoea strain infecting a patient is susceptible to an antibiotic, and will then treat on the basis of this result. By doing so, we will optimize our use of antibiotics and improve treatment strategies for gonorrhea.
Sexual And Reproductive Health And Behaviours Of Young Offenders (14-18 Years) In NSW & Qld
Funder
National Health and Medical Research Council
Funding Amount
$869,730.00
Summary
Young Indigenous and non-Indigenous offenders in Australia aged 14 and 15 years have never been systematically surveyed regarding their sexual and reproductive health in Australia. Thus we have little information on which to base education and policy initiatives. To address this knowledge gap we will systematically survey young people in contact with the juvenile justice system aged 14-18 years to provide a comprehensive picture of their sexual and reproductive behaviours and needs.
A Randomised Controlled Trial To Evaluate The Effectiveness And Cost-effectiveness Of Chlamydia Testing In General Practice.
Funder
National Health and Medical Research Council
Funding Amount
$1,377,557.00
Summary
Chlamydia is a very common sexually transmissible infection in Australia that can lead to infertility in women. About 4% of young adults have it. Most people with chlamydia do not have any symptoms and will be unaware they have it. Chlamydia is easy to diagnose and treat, but it is not known whether regular testing can reduce its spread. We propose to conduct a trial to evaluate whether annual testing for 16 to 29 year olds works and whether it would be a good use of public health funds.
A Randomised Trial Of Rapid Point-of-care Tests For Chlamydia And Gonorrhoea Infections In Remote Aboriginal Communities
Funder
National Health and Medical Research Council
Funding Amount
$788,624.00
Summary
This project will trial a new kind of test for chlamydia and gonorrhoea that can provide immediate results at the time of clinical consultation. The trial will take place in remote Aboriginal communities. These tests have the potential to reduce re-infection rates by ensuring that people with infection have timely treatment. Health services will undertake standard practice in one year, and supplement standard practice by rapid point-of-care testing in the other year in a randomly assigned order.