Comprehensive characterisation of DNA demethylation pathways in vivo. This project aims to provide a better understanding of the roles that DNA methylation plays during embryonic development. DNA methylation is a major regulatory mark present in vertebrate genomes. It is well established that the genomic patterns of DNA methylation are being actively remodelled during vertebrate embryogenesis. Nevertheless, it remains unclear how these events impact gene regulation and embryonic development itse ....Comprehensive characterisation of DNA demethylation pathways in vivo. This project aims to provide a better understanding of the roles that DNA methylation plays during embryonic development. DNA methylation is a major regulatory mark present in vertebrate genomes. It is well established that the genomic patterns of DNA methylation are being actively remodelled during vertebrate embryogenesis. Nevertheless, it remains unclear how these events impact gene regulation and embryonic development itself. This project expects to unravel the functional contributions of DNA methylation to vertebrate embryogenesis by using latest cutting-edge genomics techniques. The project will be carried out on the highly tractable zebrafish model system which allows for easy genetic manipulation of the desired sequences. This project aims to provide a better understanding of embryonic development of vertebrates, including humans.Read moreRead less
Towards a new understanding of the reproductive system. The proposed analysis of the reproductive system will provide important new knowledge of gene regulation driving organ development. The insights and technologies developed in this program will be widely applicable in biotechnological and pharmacogenomic research in Australia and worldwide, and assert Australia's leadership in this area of research.
Discovery Early Career Researcher Award - Grant ID: DE140101962
Funder
Australian Research Council
Funding Amount
$395,220.00
Summary
Functional epigenomics interrogation of DNA methylation dynamics during vertebrate development and evolution. DNA methylation (mC) is an epigenetic signal essential for the maintenance of correct gene expression patterns. To investigate the causal relationships between mC and transcription during vertebrate embryonic development and evolution, this project will perform high-resolution mC profiling at different stages of teleost, amphibian and mammalian development. Highly conserved and syntenic, ....Functional epigenomics interrogation of DNA methylation dynamics during vertebrate development and evolution. DNA methylation (mC) is an epigenetic signal essential for the maintenance of correct gene expression patterns. To investigate the causal relationships between mC and transcription during vertebrate embryonic development and evolution, this project will perform high-resolution mC profiling at different stages of teleost, amphibian and mammalian development. Highly conserved and syntenic, methylated sequences will then be used as baits in proteomics screens to identify novel 5mC 'readers'. The generation of genomic profiles of mC 'readers' and their integration with developmental mC maps will reveal transient epigenome dynamics during vertebrate embryogenesis and provide new insights into the conservation of these crucial developmental mechanisms.Read moreRead less
Multi-resolution situation recognition for urban-aware smart assistant. This project aims to develop a situation recognition framework to recognise and anticipate unforeseen emerging situations, such as schedule changes, incidents, and disruptions in an urban environment. The project will address a significant knowledge gap by capturing and modelling unpredictability in human mobility and work routines. The outcome will be a situation recognition framework that can be applied at the individual, ....Multi-resolution situation recognition for urban-aware smart assistant. This project aims to develop a situation recognition framework to recognise and anticipate unforeseen emerging situations, such as schedule changes, incidents, and disruptions in an urban environment. The project will address a significant knowledge gap by capturing and modelling unpredictability in human mobility and work routines. The outcome will be a situation recognition framework that can be applied at the individual, social group, and urban level, and at multiple locations and time scales. This should provide users with timely notifications and recommendations to resume their activities and routines. The expected benefits will be far-ranging and adaptable to many domains, from personal smart assistants to trip planning and emergency services.Read moreRead less
High Quality Gallium Oxide for Power Electronics. This project aims to combine advanced nanocharacterisation techniques with complementary expertise in semiconductor growth to produce high-quality gallium oxide that will enable fabrication of high efficiency, cost-effective power electronics. These state-of-the-art devices are urgently required to significantly reduce power conversion losses to maximise the performance and benefits of electricity generation systems using renewable energy sources ....High Quality Gallium Oxide for Power Electronics. This project aims to combine advanced nanocharacterisation techniques with complementary expertise in semiconductor growth to produce high-quality gallium oxide that will enable fabrication of high efficiency, cost-effective power electronics. These state-of-the-art devices are urgently required to significantly reduce power conversion losses to maximise the performance and benefits of electricity generation systems using renewable energy sources. The availability of superior oxide materials with bespoke electrical properties will enable the construction of fast high-voltage electronic switches, converters and other components with enhanced performance and unique capabilities.Read moreRead less
Mapping networks governing cell state plasticity: how, where and when? Single cell organisms are the basic unit of life, yet, if they had not developed the ability to change cell states we would not exist today. Changing cell states lies at the core of almost every developmental and disease process in multicellular organisms. Building upon our fundamental discovery that stem cells and non-stem cells readily interconvert, we will now incorporate innovative cell systems and the development of our ....Mapping networks governing cell state plasticity: how, where and when? Single cell organisms are the basic unit of life, yet, if they had not developed the ability to change cell states we would not exist today. Changing cell states lies at the core of almost every developmental and disease process in multicellular organisms. Building upon our fundamental discovery that stem cells and non-stem cells readily interconvert, we will now incorporate innovative cell systems and the development of our new multi-layered systems biology strategy to elucidate the first comprehensive understanding of the cell biology that underlies cell state changes. These studies are a major step toward understanding the fundamentals of life. Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE130100739
Funder
Australian Research Council
Funding Amount
$354,958.00
Summary
Deterministic coherent diffractive imaging for the nanosciences. The technological trend towards nanoscale device fabrication demands picoscale measurements which will only be possible with the development of novel and advanced imaging techniques. This project will develop and implement cutting edge approaches to lensless imaging using both electrons and x-rays and will enable real-time imaging at the picoscale.
Investigating the impact of augmented reality on consumer decision making and marketing systems. The marketing environment is changing rapidly, with mobile digital devices providing consumers the ability to augment their physical reality with virtual representations. This project investigates how consumers make choices, how manufacturers design successful business practices and how regulators proscribe manipulative behaviour in these environments.
Discovery Early Career Researcher Award - Grant ID: DE150100791
Funder
Australian Research Council
Funding Amount
$373,536.00
Summary
Identification of optically efficient erbium centres in silicon. An efficient and economical light source, an essential component for silicon integrated photonics, is still missing. This project aims to identify optically efficient erbium centres in silicon materials that are compatible with the cost-effective silicon integration technology. This project also aims to advance the microscopic study of erbium in silicon to a single-atom level and establish the essential link for optimising light em ....Identification of optically efficient erbium centres in silicon. An efficient and economical light source, an essential component for silicon integrated photonics, is still missing. This project aims to identify optically efficient erbium centres in silicon materials that are compatible with the cost-effective silicon integration technology. This project also aims to advance the microscopic study of erbium in silicon to a single-atom level and establish the essential link for optimising light emission between the microscopic structure and the optical transition. The expected outcomes are optically efficient erbium centres in silicon, which will speed up the material optimisation process and advance the development of silicon integrated photonics in Australia.Read moreRead less
A molecular timer for inflammation and cell death. This project aims to improve our understanding of the timely function of the immune system. Most processes fundamental to life rely on the timely execution of cellular functions. One biological system in which timing is paramount is the immune system. Organismal health relies upon this front-line defence system for rapidly detecting invading microbes and inducing an appropriate, and timely, antimicrobial response to clear infection. We do not cu ....A molecular timer for inflammation and cell death. This project aims to improve our understanding of the timely function of the immune system. Most processes fundamental to life rely on the timely execution of cellular functions. One biological system in which timing is paramount is the immune system. Organismal health relies upon this front-line defence system for rapidly detecting invading microbes and inducing an appropriate, and timely, antimicrobial response to clear infection. We do not currently understand how immune responses are temporally coordinated. This proposal aims to address this key knowledge gap by characterising a novel molecular timer that dictates the co-ordinated timing of immune responses and immune cell death. These studies may yield fundamental insight into mammalian anti-microbial mechanisms.Read moreRead less