Using Clinical And Economic Evidence To Infrom Local Decision Making In Cancer Care
Funder
National Health and Medical Research Council
Funding Amount
$1,836,745.00
Summary
Medicines used to treat cancer often come with a high price tag. Many countries, including Australia, are no longer able to provide free access to all medicines. For this reason, patients and their families, public hospitals and private health insurers are often asked to pay for these treatments. Currently, health professionals and patients are ill-equipped to make informed treatment choices, since both cost and efficacy must be considered. Our proposed research will address this important gap i ....Medicines used to treat cancer often come with a high price tag. Many countries, including Australia, are no longer able to provide free access to all medicines. For this reason, patients and their families, public hospitals and private health insurers are often asked to pay for these treatments. Currently, health professionals and patients are ill-equipped to make informed treatment choices, since both cost and efficacy must be considered. Our proposed research will address this important gap in current knowledge. We will use a unique web-based resource (Cancer Institute NSW Standard Cancer Treatment Program; CI-SCaT) to communicate the economic evidence needed to make informed decisions about cancer treatments. Our project will provide public access to information about the effectiveness and costs of cancer drugs. This is a world first. CI-SCaT is already the main vehicle of communication about cancer drug treatments in NSW and is widely used by cancer health professionals and patients to inform point-of-care decisions. Our project we will also identify the factors which influence the ability of cancer treatment centres to make best use of their drug budgets. By achieving this goal, we hope to demonstrate how to best use scarce resources for the benefit of all cancer patients.Read moreRead less
Investigating Best Practice Primary Care For Older Australians With Diabetes Using Data Linkage
Funder
National Health and Medical Research Council
Funding Amount
$522,278.00
Summary
This study will use data linkage to examine questions about health service use by older Australians to manage chronic conditions such as diabetes. It will lead to a better understanding of the uptake of community based care initiatives and incentives through general practice, the factors that assist or impede uptake, and the impact of these on patient outcomes such as hospitalisation. The research findings will address important questions of interest to practitioners and policy advisors.
A Novel Mechanism For Manipulation Of Peripheral Glucose Utilization In Patients With Type 2 Diabetes Mellitus.
Funder
National Health and Medical Research Council
Funding Amount
$283,500.00
Summary
Significance: Over 600,000 Australians have type 2 diabetes (approximately half are undiagnosed) and it is estimated that this number will increase substantially to 10% of the adult population over the next 10 years. At the conclusion of this grant we expect to understand whether specific signalling molecules might plausibly represent the basis of a novel therapeutic approach to control blood glucose. If successful, this work could contribute to improved metabolic control and prevention of diabe ....Significance: Over 600,000 Australians have type 2 diabetes (approximately half are undiagnosed) and it is estimated that this number will increase substantially to 10% of the adult population over the next 10 years. At the conclusion of this grant we expect to understand whether specific signalling molecules might plausibly represent the basis of a novel therapeutic approach to control blood glucose. If successful, this work could contribute to improved metabolic control and prevention of diabetic complications through new blood glucose lowering agents. Hypotheses: Muscle is the major site of glucose disposal in the body and the two most relevant stimuli for glucose uptake into muscle are insulin and muscle contraction (exercise). The insulin pathway is impaired in patients with type 2 diabetes leading to high blood glucose and complications. Glucose uptake in response to exercise however appears to be normal in patients with type 2 diabetes. Indeed we have evidence to suggest that this pathway may compensate for impaired insulin action in type 2 diabetes. We hypothesise that molecules activated by contraction (exercise) may be useful as therapies to improve resting glucose control in type 2 diabetic patients. Aims: We plan a series of three studies to examine whether glucose uptake may be improved both acutely and chronically at rest by an agent implicated in exercise mediated glucose uptake.Read moreRead less
Investigating Rising Demand For Emergency Health Care With An Ageing Population
Funder
National Health and Medical Research Council
Funding Amount
$311,860.00
Summary
The increase and acceleration in demand for emergency healthcare by the elderly is a key issue facing health policy makers. This fellowship will compare utilisation of emergency health services by elderly populations of two large Australian cities, Perth and Melbourne; and test whether an Emergency Department (ED)-based intervention reduces the likelihood of re-presentation to ED and/or hospital admission to hospital. The results will provide valuable information for service providers and policy ....The increase and acceleration in demand for emergency healthcare by the elderly is a key issue facing health policy makers. This fellowship will compare utilisation of emergency health services by elderly populations of two large Australian cities, Perth and Melbourne; and test whether an Emergency Department (ED)-based intervention reduces the likelihood of re-presentation to ED and/or hospital admission to hospital. The results will provide valuable information for service providers and policy makers.Read moreRead less
Reducing Demand On Emergency Departments In The Last Year Of Life
Funder
National Health and Medical Research Council
Funding Amount
$371,049.00
Summary
People in their last year of life who attend emergency departments (EDs) could often be better cared for elsewhere. Our severely overcrowded EDs, and the staff who work in them, are poorly equipped to provide appropriate end-of-life care. This research describes how people in their last year of life use EDs, the impact of this use upon ED services and how the provision of adequate primary care and supportive care services in the community care may be a more appropriate and economically viable op ....People in their last year of life who attend emergency departments (EDs) could often be better cared for elsewhere. Our severely overcrowded EDs, and the staff who work in them, are poorly equipped to provide appropriate end-of-life care. This research describes how people in their last year of life use EDs, the impact of this use upon ED services and how the provision of adequate primary care and supportive care services in the community care may be a more appropriate and economically viable option for people at the end-of-life.Read moreRead less
Optimising Care For Patients Diagnosed With Pancreatic Cancer: A Prospective Cohort Study
Funder
National Health and Medical Research Council
Funding Amount
$1,399,839.00
Summary
There is evidence from previous research in Queensland and NSW that elements of care provided to patients with pancreatic cancer are sub-optimal. We aim to improve compliance with evidence-based guidelines in Victoria and NSW by collecting high quality data, providing reports to hospitals benchmarking their performance against peers and working with health services to reduce variation. Making sure care known to improve practice is being delivered is as important as developing new targeted thera