A Randomised Controlled Trial Of Caseload Midwifery Care
Funder
National Health and Medical Research Council
Funding Amount
$761,311.00
Summary
There is concern about the rising levels of caesarean section in Australia and some evidence that women may benefit from caseload midwifery care. This randomised control trial will determine whether caseload midwifery care can reduce interventions and is as safe as usual hospital maternity care. A Cochrane systematic review of midwifery led care versus routine care was designed to answer these questions.This will be the first randomised controlled trial to contribute to this review
Optimising Care For Patients Diagnosed With Pancreatic Cancer: A Prospective Cohort Study
Funder
National Health and Medical Research Council
Funding Amount
$1,399,839.00
Summary
There is evidence from previous research in Queensland and NSW that elements of care provided to patients with pancreatic cancer are sub-optimal. We aim to improve compliance with evidence-based guidelines in Victoria and NSW by collecting high quality data, providing reports to hospitals benchmarking their performance against peers and working with health services to reduce variation. Making sure care known to improve practice is being delivered is as important as developing new targeted thera
Reduction Of Oxygen After Cardiac Arrest: The EXACT Trial
Funder
National Health and Medical Research Council
Funding Amount
$1,891,021.00
Summary
We aim to conduct a Phase 3 multi-centre, randomised, controlled trial to determine whether reducing oxygen administration to target a normal level as soon as possible following successful resuscitation from out-of-hospital cardiac arrest, compared to current practice of maintaining 100% oxygen, improves patient survival at hospital discharge.
Increasing the quality of goods donated to charities: Two field trials. This project aims to trial three social marketing programs using controlled field experiments in partnership with Queensland Government and the National Association of Charitable Recycling Organisations. Controlled community pilot programs are planned as a means to identify the effective program for implementation nation wide by charitable recycling organisations in Year 3 of the project. The planned research aims to incre ....Increasing the quality of goods donated to charities: Two field trials. This project aims to trial three social marketing programs using controlled field experiments in partnership with Queensland Government and the National Association of Charitable Recycling Organisations. Controlled community pilot programs are planned as a means to identify the effective program for implementation nation wide by charitable recycling organisations in Year 3 of the project. The planned research aims to increase the quality of goods donated to Australian charities. Increases in the quality of goods donated to Australian charities delivers cost savings that can in turn be used to provide essential services to support more Australians who are in need. Read moreRead less
The Effects Of Estrogen-Responsive B Box Protein On Retinoid Sensitivity In Cancer And Its Significance In Development
Funder
National Health and Medical Research Council
Funding Amount
$82,421.00
Summary
Although effective, many cancer drugs often lead to side effects, especially in children. New therapies are needed that specifically target cancer cells while leaving normal cells unaffected. I am studying a novel protein (EBBP) which I believe has an important role in cancer cell growth. By studying EBBP I aim to be able to increase the effectiveness of the low toxic chemotherapy retinoic acid without increased side effects, as well as understand the functional role of EBBP in cancer cells.
Sydney Epilepsy Incidence Study To Measure Illness Consequences (SEISMIC)
Funder
National Health and Medical Research Council
Funding Amount
$694,067.00
Summary
Epilepsy is common, costly and neglected. This study is a prospective cohort study of newly diagnosed cases of epilepsy and aims to fill clinical, psychosocial and economic knowledge gaps in epilepsy. The network will use this new evidence for policy recommendations and strategic plans, for health systems and guidelines to improve efficiency and care and to enlighten community-based support programs, education, driving and workplace legislation. This study was developed by a health service, Epil ....Epilepsy is common, costly and neglected. This study is a prospective cohort study of newly diagnosed cases of epilepsy and aims to fill clinical, psychosocial and economic knowledge gaps in epilepsy. The network will use this new evidence for policy recommendations and strategic plans, for health systems and guidelines to improve efficiency and care and to enlighten community-based support programs, education, driving and workplace legislation. This study was developed by a health service, Epilepsy Action, Epilepsy Society of Australia and the George Institute.Read moreRead less
Using Health Economics To Strengthen Ties Between Evidence, Policy And Practice In Chronic Disease
Funder
National Health and Medical Research Council
Funding Amount
$1,925,648.00
Summary
There is a major shortage of researchers with health economics expertise in Australia. This grant will provide training and development for a team of health economists to research chronic diseases covering issues such as: What is the value for money from investment in different treatments? How do such diseases affect the economic circumstances of families? How do we ensure that strategies to address illness work in practice and can be sustained? How do these issues get put on the policy agenda?
The Development Of A Composite Index Of Need For Regional Maternity Services: The Australian Regional Birthing Index (ARBI)
Funder
National Health and Medical Research Council
Funding Amount
$486,975.00
Summary
the Australian Regional Birthing Index (ARBI) is to be developed in response to the National Maternity Services Plan recommendation for an index to guide the provision of maternity services in rural and remote Australia. This index uses the size, remoteness, and vulnerability of the community, plus lessons learnt from the Canadian rural birth index. An Expert Panel of experienced clinicians, health planners and policy makers and managers of services will guide and test the feasibility of impleme ....the Australian Regional Birthing Index (ARBI) is to be developed in response to the National Maternity Services Plan recommendation for an index to guide the provision of maternity services in rural and remote Australia. This index uses the size, remoteness, and vulnerability of the community, plus lessons learnt from the Canadian rural birth index. An Expert Panel of experienced clinicians, health planners and policy makers and managers of services will guide and test the feasibility of implementing this index.Read moreRead less
Does Fresh Frozen Plasma In Russells Viper Bite Coagulopathy Reduce The Dose And Duration Of Antivenom Therapy?
Funder
National Health and Medical Research Council
Funding Amount
$622,344.00
Summary
This proposal seeks funding to undertake a trial of clotting factor replacement with low dose antivenom therapy in snake bite coagulopathy in Sri Lanka. The aim is to determine if factor replacement will result in a rapid return of clotting function, allow a smaller dose of antivenom and therefore reduce the potential risk of major bleeding and reactions to antivenom. This study will have international implications because globally snakebite coagulopathy is a major cause of morbidity and death .
Single-cell Optical Window Imaging In CDK1-FRET Biosensor Mice To Assess Tissue Stiffness And Optimise Delivery And Therapeutic Response To Gemcitabine/Abraxane In Pancreatic Cancer.
Funder
National Health and Medical Research Council
Funding Amount
$676,979.00
Summary
Inefficient drug response in solid tumour tissue is commonly a limiting factor in the clinical effectiveness of cancer therapies. Using cutting-edge imaging technology and 3D models that mimic the disease, we have mapped areas of poor drug response within distinct regions of tumours. Here, we pinpoint and specifically target key factors limiting efficient drug targeting in order to improve the encouraging anti-cancer profile of the new drug combination Gemcitabine/Abraxane in pancreatic cancer.