ImpleMentAll: Towards Evidence-based Tailored Implementation Strategies For EHealth
Funder
National Health and Medical Research Council
Funding Amount
$459,914.00
Summary
Internet-based programs to treat depression and anxiety (“iCBT” programs) are highly effective. However, there are barriers to increased public use of these programs. This project will test ways to improve the implementation of iCBT in clinical services, with a focus on GP practices. Specifically, two Australian-led subprojects will: (i) trial implementation of stepped care, tailoring care to individual needs, and (ii) compare implementation of iCBT in GP practices, pharmacies and online.
Dementia In People With Intellectual Disability: A Longitudinal Study With Focus On Translatable Outcomes.
Funder
National Health and Medical Research Council
Funding Amount
$468,151.00
Summary
People with an intellectual disability (ID) may be more prone to dementia, especially at younger ages. Dr. Evans is a psychologist whose research background is in mental health in ID. This fellowship will allow her to expand her existing study of dementia in people with ID, to examine the usefulness of selected screening tools and assessments for dementia in this group, and to identify improvements in the way that people with ID who develop dementia receive help within health system.
Increasing Rates Of Advance Care Planning For Individuals With Dementia
Funder
National Health and Medical Research Council
Funding Amount
$574,421.00
Summary
Advanced care planning improves care provided to individuals with dementia at the end of life, and lessens the burden on surviving carers and relatives.However, more than half of all people with dementia do not have an advance care plan. This study will test the effectiveness of a strategy to increase use of a website that has been developed by Alzheimer's Australia to assist people with dementia to document an advance care plan.
Reducing Alcohol Use And Related Harm In Young People
Funder
National Health and Medical Research Council
Funding Amount
$702,462.00
Summary
Nationally, 10,000 young Australians present to emergency departments with alcohol-related injuries and illnesses each month. Much of this adversity could be prevented if more young people had access to effective brief interventions (BIs) for alcohol use. Telephone-delivered BIs provide an innovative, youth friendly and accessible way of delivering treatment. This is the first clinical trial to compare the efficacy and cost-effectiveness of telephone-delivered BIs for reducing alcohol use and re ....Nationally, 10,000 young Australians present to emergency departments with alcohol-related injuries and illnesses each month. Much of this adversity could be prevented if more young people had access to effective brief interventions (BIs) for alcohol use. Telephone-delivered BIs provide an innovative, youth friendly and accessible way of delivering treatment. This is the first clinical trial to compare the efficacy and cost-effectiveness of telephone-delivered BIs for reducing alcohol use and related harm in young people.Read moreRead less
A Randomised Controlled Trial Of An Online Peer Support Intervention For Reducing Symptoms Of Depression Among Community-dwelling Older Adults Living In Rural Australia
Funder
National Health and Medical Research Council
Funding Amount
$503,180.00
Summary
Maintaining social connections as an individual ages is important to mental health. Older Australians living in rural areas are particularly at risk of social isolation, which may increase their likelihood of experiencing depression. The aim of this study is to develop and test the effectiveness of an online community in reducing depression among older Australians living in regional and rural adults. If effective, this study will provide a useful platform to combat social isolation.
Prevention Of Depression Using E Health Technologies
Funder
National Health and Medical Research Council
Funding Amount
$3,750,000.00
Summary
The number of people experiencing depression in Australia could be reduced radically if we do two things: Provide prevention programs to young people AND reduce the stigma people feel if they seek help. This research aims to develop effective, personalised school prevention programs, and deliver them to every school student in Australia. It also aims to determine how we can lower stigma across Australia by using social media.
Restoring Defective Protein Homeostasis In Frontotemporal Dementia
Funder
National Health and Medical Research Council
Funding Amount
$720,144.00
Summary
Frontotemporal dementia (FTD) is associated with pathological accumulation and aggregation of toxic proteins in affected brain regions. This project will employ a novel high throughput drug screening platform technology, FTD patient-derived nerve cells and genetic mouse models to screen drugs to improve clearance of toxic proteins and nerve cell health. This approach should accelerate discovery of agents to potentially treat the underlying cause of FTD in an effort to slow disease progression.
The Missing Link: MGluR5 As A Therapeutic Target For Cognitive Decline In Dementia
Funder
National Health and Medical Research Council
Funding Amount
$563,622.00
Summary
Cognitive decline is a core feature of Alzheimer’s Disease (AD), yet there is no cure or treatment. Recent evidence suggests that a protein called mGluR5 could cause brain cells to lose function, leading to memory loss. This project will investigate whether disrupting mGluR5 function can improve cognition in mice with genetic AD. Memory will be assessed in mice using innovative touchscreen tests that closely mimic the tests used in humans.
DIREKT: Disarming The Intravascular Innate Immune Response To Improve Modalities For Chronic Kidney Disease Treatment
Funder
National Health and Medical Research Council
Funding Amount
$362,830.00
Summary
Dialysis is the mainstay treatment for patients with end-stage kidney disease while they await transplantation. However, the dialysis process causes inflammation in patients, affecting their health and longevity. This project aims to develop new bioreagents that can be applied to dialysis devices to reduce inflammation and thus improve patient outcomes. These bioreagents will also be used to modify donor kidneys so that they are protected from inflammation associated with transplantation.