Novel Nanotechnology Strategies For Drug Co-delivery And Combined Therapies In The Brain
Funder
National Health and Medical Research Council
Funding Amount
$1,512,250.00
Summary
Key challenges for treating brain diseases include effective delivery of drugs into the brain and targeted delivery to pathogenic areas. I have developed two world-first drug delivery systems that address these challenges. This project will expand their loading and brain delivery capability to deliver a broad range of novel multiple therapeutics to target sites in the brain. Human brain disease models will be used for systematic preclinical evaluation of novel delivery systems and therapeutics.
A Long-Lasting Oral Drug Delivery System Using Spiky Silica Nanoparticles
Funder
National Health and Medical Research Council
Funding Amount
$645,205.00
Summary
This project aims to develop a novel silica nanoparticle-based delivery system for long-lasting oral drug delivery. The particles will be engineered with a spiky morphology that will increase adhesion to the gastrointestinal tract enabling sustained drug release for days or even weeks. Longer lasting oral drug formulations would make it much easier for patients to adhere to the treatment schedules required in chronic diseases like HIV and increase the effectiveness of therapy.
The role of community music in addressing social inequalities in Australia. This project aims to investigate the role community music can play in addressing social inequalities in Australia. The research expects to map and analyse a range of social outcomes fostered by community music, and investigate how these outcomes can enrich current place-based efforts to address social disadvantage. Through national sector mapping, community case studies, and an innovative analytic framework, expected out ....The role of community music in addressing social inequalities in Australia. This project aims to investigate the role community music can play in addressing social inequalities in Australia. The research expects to map and analyse a range of social outcomes fostered by community music, and investigate how these outcomes can enrich current place-based efforts to address social disadvantage. Through national sector mapping, community case studies, and an innovative analytic framework, expected outcomes include new interdisciplinary knowledge, music and social sector development, and greater creativity in place-based policies tackling inequalities. This should provide significant benefits for Australian communities where social inequalities exist, by harnessing their creative assets to drive positive social change. Read moreRead less
Confronting everyday harms: preventing abuse of people with disability. The findings of the Disability Royal Commission necessitate new approaches to prevent violence, abuse, neglect and exploitation. Framed by recognition theory, this project proposes empirical research with young people with cognitive disability, using a new concept of ‘everyday harms’ in their paid relationships. The results will inform early responses to poor quality interactions in disability support. The strategic alliance ....Confronting everyday harms: preventing abuse of people with disability. The findings of the Disability Royal Commission necessitate new approaches to prevent violence, abuse, neglect and exploitation. Framed by recognition theory, this project proposes empirical research with young people with cognitive disability, using a new concept of ‘everyday harms’ in their paid relationships. The results will inform early responses to poor quality interactions in disability support. The strategic alliances with the government, industry and community partners will develop a practice framework to prevent everyday harms and the escalation to abuse, and to promote safety and wellbeing. The research has policy benefits for capacity-building in the sector to act on the rights and voices of people with disability. Read moreRead less
Codesigning processes to improve technology service provision for aged care. This research investigates the learning and implementation of novel technologies applying a participatory approach with aged care residents. In partnership with Martin Luther Homes (a not-for-profit aged care provider) and The Brainary (an educational technology provider), we will co-design recommendations and innovative services that are necessary to enable strategic planning and technology uptake of residents. We cre ....Codesigning processes to improve technology service provision for aged care. This research investigates the learning and implementation of novel technologies applying a participatory approach with aged care residents. In partnership with Martin Luther Homes (a not-for-profit aged care provider) and The Brainary (an educational technology provider), we will co-design recommendations and innovative services that are necessary to enable strategic planning and technology uptake of residents. We create value through the shared goal orientation bringing use of technology in aged care and business together as a service. Co-creating processes exploring technologies with older adults will translate into residents receiving the support they need. We can expect to achieve better quality of care and equity in technology use. Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE220100903
Funder
Australian Research Council
Funding Amount
$451,885.00
Summary
Charitable triad: How donors, beneficiaries, & fundraisers influence giving. This project aims to test a new model of charitable giving to examine how donors, beneficiaries, and fundraisers together influence donor decisions. Until now, no holistic model has existed to explain donor behaviour: past research has focused on donors but neglected beneficiaries and fundraisers. This project is expected to provide evidence for a new bedrock theory of philanthropy. Findings can also inform practitioner ....Charitable triad: How donors, beneficiaries, & fundraisers influence giving. This project aims to test a new model of charitable giving to examine how donors, beneficiaries, and fundraisers together influence donor decisions. Until now, no holistic model has existed to explain donor behaviour: past research has focused on donors but neglected beneficiaries and fundraisers. This project is expected to provide evidence for a new bedrock theory of philanthropy. Findings can also inform practitioner toolkits, offering advice to nonprofits on how to raise money effectively by understanding how the particular organisation and its beneficiaries can influence donor decisions. By helping ensure the survival of charities, this research will contribute to the delivery of essential social services that benefit many Australians.Read moreRead less
Synergising nanoemulsion and lipid biomimetic design for advanced delivery. This project aims to identify the critical design characteristics of lipid formulations of lipid-modified probes or drugs (lipid biomimetics) that together promote integration into lipid absorption pathways and target the lymphatic system that drains the small intestine. This has significant potential since the intestinal lymphatic system is a key immune tissue, the site of immune response to autoantigens and antigens de ....Synergising nanoemulsion and lipid biomimetic design for advanced delivery. This project aims to identify the critical design characteristics of lipid formulations of lipid-modified probes or drugs (lipid biomimetics) that together promote integration into lipid absorption pathways and target the lymphatic system that drains the small intestine. This has significant potential since the intestinal lymphatic system is a key immune tissue, the site of immune response to autoantigens and antigens derived from food and the microbiome. The project will deliver a design roadmap of the required characteristics for lymphatic targeting, and in particular, will identify novel lipid nanoemulsions that work synergistically with lipid biomimetics to enhance lymphatic imaging and delivery applications.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE210101175
Funder
Australian Research Council
Funding Amount
$408,643.00
Summary
The asset state: Comparing new models for financing public investment. This project aims to investigate policy models that account for public spending as an asset rather than a cost. The project expects to build knowledge about how changes in the way governments budget for and deliver funding create new options for public investment. The project develops a comparative study of the relationship between accounting reforms and financing models for higher education, social housing and renewable ener ....The asset state: Comparing new models for financing public investment. This project aims to investigate policy models that account for public spending as an asset rather than a cost. The project expects to build knowledge about how changes in the way governments budget for and deliver funding create new options for public investment. The project develops a comparative study of the relationship between accounting reforms and financing models for higher education, social housing and renewable energy in Australia and the UK. Expected outcomes include conceptualising new spaces of fiscal power in the 'asset state' and developing tools for policy makers to guide budgetary choices. This should provide significant benefits by identifying equitable and sustainable ways to pay for critical services and infrastructure.Read moreRead less
The production, use and effect of social work research. This project aims to reform social work research to improve the quality and effectiveness of human services. The human services industry is vital to many people’s quality of life, but lacks innovation and struggles to demonstrate its effectiveness. Crucially for social work, research expands thinking about how to respond to social disadvantage. This project intends to examine the scope and quality of Australian social work research in child ....The production, use and effect of social work research. This project aims to reform social work research to improve the quality and effectiveness of human services. The human services industry is vital to many people’s quality of life, but lacks innovation and struggles to demonstrate its effectiveness. Crucially for social work, research expands thinking about how to respond to social disadvantage. This project intends to examine the scope and quality of Australian social work research in child protection, disability services, and aged care; assess the use of this research to the human services sector and its effect on generating innovation; and develop strategies to advance the production, uptake, and effect of social work research.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC210100040
Funder
Australian Research Council
Funding Amount
$4,997,903.00
Summary
ARC Training Centre for Facilitated Advancement of Australia's Bioactives (FAAB). The Centre for Facilitated Advancement of Australia's Bioactives (FAAB) will transform the rapidly growing bioactive ingredients sector. It will apply advanced analytical methods to molecular characterisation of bioactive products derived from foods, food-waste, and cell-based biotechnologies. FAAB will determine modes of action for bioactives with potential lifestyle and nutritional benefits allowing for evidence- ....ARC Training Centre for Facilitated Advancement of Australia's Bioactives (FAAB). The Centre for Facilitated Advancement of Australia's Bioactives (FAAB) will transform the rapidly growing bioactive ingredients sector. It will apply advanced analytical methods to molecular characterisation of bioactive products derived from foods, food-waste, and cell-based biotechnologies. FAAB will determine modes of action for bioactives with potential lifestyle and nutritional benefits allowing for evidence-informed decision-making, and regulatory framework development. FAAB graduates will lead and deliver future national self-reliance to the Australian bioactives sector, increasing diversification and international competitiveness and development of regulation in a growing market. Read moreRead less