Cortical Networks That Integrate Auditory Input And Speech Motor Output In Human Stutterers
Funder
National Health and Medical Research Council
Funding Amount
$292,639.00
Summary
Stuttering is a chronic communication disorder that arises from problems in the brain processes that control speech. This research aims to use magnetoencephalography, a new and extremely fast method of brain imaging, to study the parts of the human brain that underlie speech production. By studying the brains of both child and adult stutterers the causes of stuttering will become more apparent. Ultimately, this research will lead to more effective treatments for stuttering.
Mechanisms Of Body Representation And The Sensory Consequences Of Stroke
Funder
National Health and Medical Research Council
Funding Amount
$408,842.00
Summary
How does the brain control movement without vision? We cannot see our mouth but can easily put food in it. The brain uses a combination of sensory signals and stored models of the body, to control movement. The body models, and their interaction with sensory information, is not well understood. but they are disrupted by common clinical disorders. This research project investigates unsolved questions about the body model including how it is affected by stroke.
Mechanisms Of Cortical Plasticity And Facilitation Of Functional Recovery Following Stroke
Funder
National Health and Medical Research Council
Funding Amount
$427,500.00
Summary
Specific regions of the human brain have been shown to reorganise following damage to the brain or peripheral nerves. This reorganisation is seen in both young and older subjects and is thought to be useful in helping to restore function. For example, following a stroke a patient may, initially, be unable to move one arm. However, in the following weeks and months some function may return. A number of mechanisms may be responsible for this improvement. However, it is likely that at least some of ....Specific regions of the human brain have been shown to reorganise following damage to the brain or peripheral nerves. This reorganisation is seen in both young and older subjects and is thought to be useful in helping to restore function. For example, following a stroke a patient may, initially, be unable to move one arm. However, in the following weeks and months some function may return. A number of mechanisms may be responsible for this improvement. However, it is likely that at least some of the improvement is due to reorganisation within the sensorimotor cortex. Following the stroke the control of the arm may be taken over by adjacent undamaged regions of the brain. This reorganisation allows impressive functional recoveries to occur. We have preliminary evidence to support the idea that patterns of activity generated in peripheral nerves (afferent input) following stroke may be crucial for the development of the organisational changes seen within the brain. We have shown that by applying specific patterns of sensory input we are able to produce organisational changes within the motor cortex of control subjects. Also, we have been able to induce similar changes in stroke patients. These changes have been accompanied by improvements in motor control. These novel and exciting findings support our hypothesis that by applying certain patterns of afferent input to patients following stroke we will be able to facilitate functional recovery by maximising reoganisation within the cortex. In the present project we will establish the organisation patterns in the brain of stroke patients and contrast the findings with control subjects. Secondly we will investigate the potential for facilitating recovery of stroke patients by the application of specific patterns of afferent input. These novel experiments may lead to important therapeutic developments that will benefit the large population of patients suffering strokes.Read moreRead less
Neuronal Activity And Variability Underlying Perception And Action
Funder
National Health and Medical Research Council
Funding Amount
$349,802.00
Summary
Perception and behaviour are often unpredictable. We do not identically perceive repeated stimuli, and even professional athletes cannot precisely replicate their actions. This project compares variations in the activity of motion-sensitive neurons in the brain with variability in motion perception and eye movements. This should give insights into how neuronal activity underlies conscious perception and eye movements and may ultimately help treat conditions with impaired control of movement.
Understanding The Brain In The Transition From Acute To Chronic Low Back Pain
Funder
National Health and Medical Research Council
Funding Amount
$107,049.00
Summary
A critical question in treating low back pain (LBP) is why some people get better after hurting their back while others do not. Physiological mechanisms, such as brain plasticity and central sensitisation, are believed to underpin the transition to persistent pain. This is the first study to evaluate these mechanisms longitudinally and their relationship with LBP outcomes. The result of this research will provide better understanding of pain mechanisms of LBP and assist to develop novel therapy.
Functional Neuroimaging Of Prepulse Inhibition In Schizophrenia And Parkinson's Disease
Funder
National Health and Medical Research Council
Funding Amount
$446,750.00
Summary
Inhibition deficits have been consistently demonstrated in a broad spectrum of neuropsychiatric conditions that have been implicated with altered neurotransmitter function of the brain. These conditions include mental disorders like schizophrenia, obsessive-compulsive disorder, and pathological gambling and neurological disorders like Huntington's disease, Gilles-de-la-Tourette syndrome and other conditions which are characterised by impaired impulse control. Studies on animal models suggest tha ....Inhibition deficits have been consistently demonstrated in a broad spectrum of neuropsychiatric conditions that have been implicated with altered neurotransmitter function of the brain. These conditions include mental disorders like schizophrenia, obsessive-compulsive disorder, and pathological gambling and neurological disorders like Huntington's disease, Gilles-de-la-Tourette syndrome and other conditions which are characterised by impaired impulse control. Studies on animal models suggest that an impaired dopamine neurotransmission - either genetically pre-determined and-or stress-induced by environmental factors - may significantly contribute to a common pathological mechanism across these conditions that, in turn, results in impaired 'sensory motor gating', a physiological measure of inhibitory brain processes. Traditionally, sensory motor gating is indirectly measured using the acoustic startle eye-blink response. However, this peripheral measure cannot directly assess the brain processes underlying sensory motor gating. This study will apply new functional brain imaging methodology and EEG-based source localisation techniques to assess the neural substrates of inhibitory processes involved in sensory motor gating in two neuropsychiatric conditions that involve dysfunctional dopaminergic mechanisms: schizophrenia and Parkinson's disease.Read moreRead less
The secret of tiny hand movements to feel and manipulate objects. This study aims to reveal some of the fundamental sensory mechanisms underlying the uniquely human ability to manipulate objects and use tools. Signals from touch receptors are crucial for controlling grip forces so that delicate objects are held without slipping, or being crushed by excessive force. Yet we know little about how such sensory information is obtained and how it is used for the motor control. By analysing hand moveme ....The secret of tiny hand movements to feel and manipulate objects. This study aims to reveal some of the fundamental sensory mechanisms underlying the uniquely human ability to manipulate objects and use tools. Signals from touch receptors are crucial for controlling grip forces so that delicate objects are held without slipping, or being crushed by excessive force. Yet we know little about how such sensory information is obtained and how it is used for the motor control. By analysing hand movements during object manipulation and recording sensory signals from single human nerve fibres we will investigate how certain types of movement shape richness of available sensory information. This knowledge will facilitate the development of next generation sensory-controlled prosthetics and robotic manipulators.Read moreRead less