Sensory Coding Mechanisms in Rat Somatosensory System; A Combined Behavioural and Electrophysiological Approach. This inter-disciplinary project spans behavioural sciences, neurophysiology and computational neuroscience. It investigates fundamental questions such as how different aspects of stimuli are presented in sensory areas of the brain and how the animal interprets the neuronal activity in such areas to generate the relevant behaviour. A major problem with making prosthetic sensory devices ....Sensory Coding Mechanisms in Rat Somatosensory System; A Combined Behavioural and Electrophysiological Approach. This inter-disciplinary project spans behavioural sciences, neurophysiology and computational neuroscience. It investigates fundamental questions such as how different aspects of stimuli are presented in sensory areas of the brain and how the animal interprets the neuronal activity in such areas to generate the relevant behaviour. A major problem with making prosthetic sensory devices is the way by which these devices can communicate with the brain. Research into the coding of different features of simple stimuli will provide basic knowledge which can be implemented in prosthetic sensory devices. Read moreRead less
Complex Motion Processing in Primate Visual Cortex. As we move through the world, a dynamic visual image is projected onto our retinas. The pattern of movement in the retinal image contains information about three-dimensional structure in the environment and the time of impending collisions. Our visual systems are expert at exploiting this information, enabling us to navigate through complex visual environments at a level far beyond the most sophisticated artificial systems. We plan to investiga ....Complex Motion Processing in Primate Visual Cortex. As we move through the world, a dynamic visual image is projected onto our retinas. The pattern of movement in the retinal image contains information about three-dimensional structure in the environment and the time of impending collisions. Our visual systems are expert at exploiting this information, enabling us to navigate through complex visual environments at a level far beyond the most sophisticated artificial systems. We plan to investigate complex motion processing in the primate brain by recording the responses of neurons in identified regions of the visual cortex of macaque monkeys to a range of behaviourally relevant motion stimuli.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0452971
Funder
Australian Research Council
Funding Amount
$102,900.00
Summary
Optical imaging of brain activity: Studies of the neural basis of sensory perception, plasticity and behaviour. Basic to the understanding of the brain is to know how the overall architecture of the nervous system relates to its function. We propose to study this by directly visualising the regions that are functionally active in the living brains of animals, down to resolution limits of less than 100 micrometres. Such "optical imaging" will be done by recording light reflected from the surfac ....Optical imaging of brain activity: Studies of the neural basis of sensory perception, plasticity and behaviour. Basic to the understanding of the brain is to know how the overall architecture of the nervous system relates to its function. We propose to study this by directly visualising the regions that are functionally active in the living brains of animals, down to resolution limits of less than 100 micrometres. Such "optical imaging" will be done by recording light reflected from the surface of the brain, which in turn depends upon activity-dependent intrinsic signals (eg. degree of oxygenation of haemoglobin). These signals will be recorded by a special camera and amplified using the requested system.Read moreRead less
Visual processing in a unique modular system - how can a simple cognitive architecture be used to solve complex visual tasks? The proposed interdisciplinary study of the visual system of jumping spiders will provide novel insights into how a simple cognitive architecture can be used to solve complex visual tasks. This will be the first comprehensive study of motion sensitivity in a spider. The insights obtained will be important for the development of artificial intelligence systems. We will pro ....Visual processing in a unique modular system - how can a simple cognitive architecture be used to solve complex visual tasks? The proposed interdisciplinary study of the visual system of jumping spiders will provide novel insights into how a simple cognitive architecture can be used to solve complex visual tasks. This will be the first comprehensive study of motion sensitivity in a spider. The insights obtained will be important for the development of artificial intelligence systems. We will provide a stimulating environment to train a postdoctoral fellow with state-of-art skills ranging from single-cell neurophysiology through to using 3D animation for sophisticated behavioural assays. The proposed work is a hot topic and will attract considerable attention, raise the profile of Australian science, and support postgraduate students. Read moreRead less
A molecular structure-function investigation of major membrane channels involved in olfactory transduction. Olfactory receptor neurons are extraordinarily-sensitive sensors for detecting minute concentrations of odorant molecules. This project aims to extend our previous studies of these specialised mammalian olfactory cells by using state-of-the art technologies: electrophysiology (patch-clamp) and molecular biology (site-directed-mutagenesis), to investigate how the molecular structure of the ....A molecular structure-function investigation of major membrane channels involved in olfactory transduction. Olfactory receptor neurons are extraordinarily-sensitive sensors for detecting minute concentrations of odorant molecules. This project aims to extend our previous studies of these specialised mammalian olfactory cells by using state-of-the art technologies: electrophysiology (patch-clamp) and molecular biology (site-directed-mutagenesis), to investigate how the molecular structure of their ion channels (selective protein pores) and receptors contribute to the odorant-induced generation of electrical activity, which mediates our sense of smell (olfaction). The project has specific relevance for understanding olfaction, as well as relevance for other sensory systems and other ion channels.Read moreRead less
Neural mechanisms for human form perception. This project aims to determine if there is a single cortical mechanism underlying the human ability to discriminate and recognise objects. It has been speculated that different classes of objects, or forms require different processes. Demonstrating a single process would be a significant advance towards understanding the neural mechanisms giving rise to our ability to segment visual fields into meaningful objects and background. This research provides ....Neural mechanisms for human form perception. This project aims to determine if there is a single cortical mechanism underlying the human ability to discriminate and recognise objects. It has been speculated that different classes of objects, or forms require different processes. Demonstrating a single process would be a significant advance towards understanding the neural mechanisms giving rise to our ability to segment visual fields into meaningful objects and background. This research provides a means for testing models of the neural interactions thought to be generating human form perception and will help us discover how the visual cortex converts raw sensory input into object and form perception.Read moreRead less
Functional imaging of colour pathways in the living eye. In order to repair or regenerate a diseased eye, we require knowledge of the normal pattern or nerve cell connections, and knowing how biology solves the problem of colour vision can be used to improve the design of artificial vision systems. The adaptive optics machine we will build in this project can be used to image nerve cells, fine blood vessels, and nerve fibre bundles in the normal and diseased eye. This will improve Australia's re ....Functional imaging of colour pathways in the living eye. In order to repair or regenerate a diseased eye, we require knowledge of the normal pattern or nerve cell connections, and knowing how biology solves the problem of colour vision can be used to improve the design of artificial vision systems. The adaptive optics machine we will build in this project can be used to image nerve cells, fine blood vessels, and nerve fibre bundles in the normal and diseased eye. This will improve Australia's research and development capacity in this new area of medical diagnostics. Our machine will be made available to other Australian laboratories and will improve the national capacity for making further scientific discoveries about how the visual system works.Read moreRead less
Special Research Initiatives - Grant ID: SR0354793
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
A Neural Network: Understanding Brain Function. This proposal focuses on the mechanisms that regulate brain function, particularly those underpinning the changes in circuitry (plasticity) caused by altered inputs. As such, its core goal is to create an interface between researchers in the neurosciences, computational modelling, robotics and cognitive sciences in order to facilitate optimum collaborative interactions, identify key research questions and promote training opportunities across a mul ....A Neural Network: Understanding Brain Function. This proposal focuses on the mechanisms that regulate brain function, particularly those underpinning the changes in circuitry (plasticity) caused by altered inputs. As such, its core goal is to create an interface between researchers in the neurosciences, computational modelling, robotics and cognitive sciences in order to facilitate optimum collaborative interactions, identify key research questions and promote training opportunities across a multidisciplinary spectrum. This will drive an integrated and accelerated program of discovery and technological development, enhancing Australia's leadership in this crucial field and helping to highlight new biotechnology opportunities and capture social and economic benefits for the nation. Read moreRead less
Are there advantages in having a lateralized brain? Specialisation of the left and right hemispheres of the brain to process different information and to control different responses is not, as once thought, unique to humans but common to all vertebrates. In fact, the same general pattern of lateralization occurs in amphibians, reptiles, birds and mammals. Until now, it has been important to document the presence and nature of lateralization in different species. Now it is important to discover t ....Are there advantages in having a lateralized brain? Specialisation of the left and right hemispheres of the brain to process different information and to control different responses is not, as once thought, unique to humans but common to all vertebrates. In fact, the same general pattern of lateralization occurs in amphibians, reptiles, birds and mammals. Until now, it has been important to document the presence and nature of lateralization in different species. Now it is important to discover the advantages (and disadvantages) of having a lateralized brain. This project will do so using two model species, the chick and the marmoset, and new techniques to measure behaviour.Read moreRead less
How Stenolemus Assassin Bugs Crack Spider Codes. This unique study of sophisticated behavioural flexibility and dynamic sensory exploitation in an insect will provide novel insights into how simple cognitive architecture can be used to solve complex problems. These insights are important for the development of artificial intelligence systems. This will be the first study of flexible aggressive mimicry in an insect and will attract considerable international attention, raise the profile of Austra ....How Stenolemus Assassin Bugs Crack Spider Codes. This unique study of sophisticated behavioural flexibility and dynamic sensory exploitation in an insect will provide novel insights into how simple cognitive architecture can be used to solve complex problems. These insights are important for the development of artificial intelligence systems. This will be the first study of flexible aggressive mimicry in an insect and will attract considerable international attention, raise the profile of Australian science and support numerous students. We will make the first use in Australia of state-of-the-art vibration recording and interactive playback techniques. Making these powerful experimental tools available in Australia will enable other many additional innovative lines of research.Read moreRead less