Chromatic Inputs to Cortical Receptive Fields in Primates. The human eye contains three kinds of receptors for daytime vision, named blue, green and red cones for their sensitivity to different regions of the visible spectrum. It is known that blue cones contribute to brain pathways for colour vision, but recent data suggest there is also 'cross-talk' of blue cone signals to pathways for motion and high-acuity vision. This project comprises precise measurement of blue cone signals, and anatomica ....Chromatic Inputs to Cortical Receptive Fields in Primates. The human eye contains three kinds of receptors for daytime vision, named blue, green and red cones for their sensitivity to different regions of the visible spectrum. It is known that blue cones contribute to brain pathways for colour vision, but recent data suggest there is also 'cross-talk' of blue cone signals to pathways for motion and high-acuity vision. This project comprises precise measurement of blue cone signals, and anatomical tracing of blue cone pathways, in a primate model for human vision. The data will improve our basic knowledge of how the brain processes sensory signals.Read moreRead less
The Claustrum Enigma: Unlocking The Role Of The Last Unknown Area Of The Primate Brain
Funder
National Health and Medical Research Council
Funding Amount
$558,364.00
Summary
Despite nearly 200 years of study, the function of the claustrum remains unclear. Interest in this brain structure has recently been revived by findings showing damage to the claustrum in several major diseases, and by the suggestion that the claustrum may have a role in consciousness. Here we propose a series of experiments to test the novel hypothesis that the claustrum is part of the default mode network, a group of brain areas that act together when we aren't thinking about anything in parti ....Despite nearly 200 years of study, the function of the claustrum remains unclear. Interest in this brain structure has recently been revived by findings showing damage to the claustrum in several major diseases, and by the suggestion that the claustrum may have a role in consciousness. Here we propose a series of experiments to test the novel hypothesis that the claustrum is part of the default mode network, a group of brain areas that act together when we aren't thinking about anything in particular, that is- most of the time.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0452971
Funder
Australian Research Council
Funding Amount
$102,900.00
Summary
Optical imaging of brain activity: Studies of the neural basis of sensory perception, plasticity and behaviour. Basic to the understanding of the brain is to know how the overall architecture of the nervous system relates to its function. We propose to study this by directly visualising the regions that are functionally active in the living brains of animals, down to resolution limits of less than 100 micrometres. Such "optical imaging" will be done by recording light reflected from the surfac ....Optical imaging of brain activity: Studies of the neural basis of sensory perception, plasticity and behaviour. Basic to the understanding of the brain is to know how the overall architecture of the nervous system relates to its function. We propose to study this by directly visualising the regions that are functionally active in the living brains of animals, down to resolution limits of less than 100 micrometres. Such "optical imaging" will be done by recording light reflected from the surface of the brain, which in turn depends upon activity-dependent intrinsic signals (eg. degree of oxygenation of haemoglobin). These signals will be recorded by a special camera and amplified using the requested system.Read moreRead less
Neural origins of conscious perception in no-report paradigms. This project aims to test two highly influential theories of consciousness. The project will be the first to test critical experimental conditions, where neural activities are recorded in humans and novel measures of causality are computed, which allows us to distinguish the two theories. The intended outcomes will provide significant benefits by bringing us closer to solve the mind-body problem. These outcomes can contribute to the ....Neural origins of conscious perception in no-report paradigms. This project aims to test two highly influential theories of consciousness. The project will be the first to test critical experimental conditions, where neural activities are recorded in humans and novel measures of causality are computed, which allows us to distinguish the two theories. The intended outcomes will provide significant benefits by bringing us closer to solve the mind-body problem. These outcomes can contribute to the development of engineering and clinical devices that utilise objective measures of consciousness.Read moreRead less
Functional imaging of colour pathways in the living eye. In order to repair or regenerate a diseased eye, we require knowledge of the normal pattern or nerve cell connections, and knowing how biology solves the problem of colour vision can be used to improve the design of artificial vision systems. The adaptive optics machine we will build in this project can be used to image nerve cells, fine blood vessels, and nerve fibre bundles in the normal and diseased eye. This will improve Australia's re ....Functional imaging of colour pathways in the living eye. In order to repair or regenerate a diseased eye, we require knowledge of the normal pattern or nerve cell connections, and knowing how biology solves the problem of colour vision can be used to improve the design of artificial vision systems. The adaptive optics machine we will build in this project can be used to image nerve cells, fine blood vessels, and nerve fibre bundles in the normal and diseased eye. This will improve Australia's research and development capacity in this new area of medical diagnostics. Our machine will be made available to other Australian laboratories and will improve the national capacity for making further scientific discoveries about how the visual system works.Read moreRead less
Central pathways regulating visceral pain. This project aims to investigate the neural pathways within the spinal cord and brain processing colorectal pain perception. The project aims to identify the spinal cord neurons relaying colorectal signalling into the brain and the influence of descending modulation from the brainstem upon these pathways. The outcomes will greatly benefit fundamental understanding of the central pathways processing visceral pain.
The processing of sensory information within cortical circuits. This project aims to improve our knowledge of neuronal activity during sensory perception and therefore shed light on overall brain function during behaviour. Understanding how dendrites receive and process this information is crucial to understanding brain function during sensory processing and perception. This proposal aims to characterise dendritic activity during sensory input and discover how this activity contributes to behavi ....The processing of sensory information within cortical circuits. This project aims to improve our knowledge of neuronal activity during sensory perception and therefore shed light on overall brain function during behaviour. Understanding how dendrites receive and process this information is crucial to understanding brain function during sensory processing and perception. This proposal aims to characterise dendritic activity during sensory input and discover how this activity contributes to behavioural tasks. In particular, the project plans to investigate activity of different dendritic domains during sensory perception and sensory-based behaviour. The project seeks to improve our knowledge of the importance of dendrites in transforming information from the sensory environment and highlight the cellular and network mechanisms contributing to behaviour.Read moreRead less
Relationship of the functional architecture of the mammalian brain to its microcircuitry. The project seeks to understand a very fundamental issue in neuroscience: how the connectivity and architecture of the cortex are related to the functions of neurones in that area? This will be investigated by imaging the surface of the visual cortex of anaesthetised cats and monkeys as special visual patterns are shown to the eye/s. The overall picture gained of the active and inactive cortical areas will ....Relationship of the functional architecture of the mammalian brain to its microcircuitry. The project seeks to understand a very fundamental issue in neuroscience: how the connectivity and architecture of the cortex are related to the functions of neurones in that area? This will be investigated by imaging the surface of the visual cortex of anaesthetised cats and monkeys as special visual patterns are shown to the eye/s. The overall picture gained of the active and inactive cortical areas will be related to the properties of neurones in those areas and to those of individual input and output fibres. An optical imaging equipment will be acquired in 2004 using a recently awarded LIEF grant to the CI.Read moreRead less
Thalamic inputs and cortical microcircuitry underlying the functional architecture of the visual cortex. This project seeks to reveal the fundamental circuitry of the visual cortex that enables visual perception. Such understanding is essential not only for explaining many perceptual disturbances, but also for providing a neuronal basis for developing functionally useful prostheses for the blind.
The advantage of being magnocellular: the role of the dorsal visual stream in object identification. The primary benefit of this project is to basic science and tertiary teaching globally. Visual processing and how it activates attention and operates to guide actions and cognitive behaviour is fundamental to our understanding of life and brain evolution. In particular this new knowledge will further understanding of many cognitive symptoms associated with neurodevelopmental disorders and in the ....The advantage of being magnocellular: the role of the dorsal visual stream in object identification. The primary benefit of this project is to basic science and tertiary teaching globally. Visual processing and how it activates attention and operates to guide actions and cognitive behaviour is fundamental to our understanding of life and brain evolution. In particular this new knowledge will further understanding of many cognitive symptoms associated with neurodevelopmental disorders and in the future should lead to design of better educational technologies for such children. Similarly understanding of temporal sequencing of vision has commercial implications for design of bionic eyes and robotic vision processing.Read moreRead less