Centre-surround interactions in ageing human vision. Australia has a rapidly ageing population. This project will study how ageing affects the visual perception of objects presented on non-uniform backgrounds. Our ability to discriminate objects from their backgrounds is key to most natural visual tasks. The visual processes involved are known as centre-surround interactions, and are considered fundamental building blocks to human perception. This project will significantly advance our knowledge ....Centre-surround interactions in ageing human vision. Australia has a rapidly ageing population. This project will study how ageing affects the visual perception of objects presented on non-uniform backgrounds. Our ability to discriminate objects from their backgrounds is key to most natural visual tasks. The visual processes involved are known as centre-surround interactions, and are considered fundamental building blocks to human perception. This project will significantly advance our knowledge of which spatial visual mechanisms are altered due to age, supplying key information for understanding and improving visual environments for the elderly, as well as increasing knowledge of the brain mechanisms susceptible to the ageing process.Read moreRead less
Chromatic Inputs to Cortical Receptive Fields in Primates. The human eye contains three kinds of receptors for daytime vision, named blue, green and red cones for their sensitivity to different regions of the visible spectrum. It is known that blue cones contribute to brain pathways for colour vision, but recent data suggest there is also 'cross-talk' of blue cone signals to pathways for motion and high-acuity vision. This project comprises precise measurement of blue cone signals, and anatomica ....Chromatic Inputs to Cortical Receptive Fields in Primates. The human eye contains three kinds of receptors for daytime vision, named blue, green and red cones for their sensitivity to different regions of the visible spectrum. It is known that blue cones contribute to brain pathways for colour vision, but recent data suggest there is also 'cross-talk' of blue cone signals to pathways for motion and high-acuity vision. This project comprises precise measurement of blue cone signals, and anatomical tracing of blue cone pathways, in a primate model for human vision. The data will improve our basic knowledge of how the brain processes sensory signals.Read moreRead less
The Claustrum Enigma: Unlocking The Role Of The Last Unknown Area Of The Primate Brain
Funder
National Health and Medical Research Council
Funding Amount
$558,364.00
Summary
Despite nearly 200 years of study, the function of the claustrum remains unclear. Interest in this brain structure has recently been revived by findings showing damage to the claustrum in several major diseases, and by the suggestion that the claustrum may have a role in consciousness. Here we propose a series of experiments to test the novel hypothesis that the claustrum is part of the default mode network, a group of brain areas that act together when we aren't thinking about anything in parti ....Despite nearly 200 years of study, the function of the claustrum remains unclear. Interest in this brain structure has recently been revived by findings showing damage to the claustrum in several major diseases, and by the suggestion that the claustrum may have a role in consciousness. Here we propose a series of experiments to test the novel hypothesis that the claustrum is part of the default mode network, a group of brain areas that act together when we aren't thinking about anything in particular, that is- most of the time.Read moreRead less
The brain in real time: a neural model of rhythmic action and perception. This project aims to study a fundamental function of the human brain: its temporal architecture. It will provide an innovative perspective on the neural mechanisms underlying and relating perception, intention, and voluntary action in real time, though a combination of eye-tracking, behaviour, and neural recordings. By providing a common language with which to relate perception, cognition, volition and action, this will ....The brain in real time: a neural model of rhythmic action and perception. This project aims to study a fundamental function of the human brain: its temporal architecture. It will provide an innovative perspective on the neural mechanisms underlying and relating perception, intention, and voluntary action in real time, though a combination of eye-tracking, behaviour, and neural recordings. By providing a common language with which to relate perception, cognition, volition and action, this will provide significant benefits that will transform the way we think about brain function.Read moreRead less
Colour visual processing by honeybees: solutions for decision making in complex environments. Honeybees are a cost and time efficient animal model for testing how information is processed in a miniature brain containing less than 0.01% of the number of cells found in a human brain. Bees use their ultraviolet, blue and green colour vision to efficiently find flowers in complex environments. This project investigates how colour information is processed by bees, and develops computer models to eval ....Colour visual processing by honeybees: solutions for decision making in complex environments. Honeybees are a cost and time efficient animal model for testing how information is processed in a miniature brain containing less than 0.01% of the number of cells found in a human brain. Bees use their ultraviolet, blue and green colour vision to efficiently find flowers in complex environments. This project investigates how colour information is processed by bees, and develops computer models to evaluate how novel solutions might be applicable for robotic vision. The model also allows for testing of how environmental factors, like changes in climate, might affect the way in which bees choose to visit certain flower types, including plants that have important environmental and economic impacts.Read moreRead less
Resolving multi-sensory conflict as we age: audio-visual integration and the role of normal and abnormal sensory decline. Australia has an ageing population. Even the healthiest older individuals undergo some deterioration of vision and hearing, however, these senses are almost invariably studied in isolation. The real world is multisensory. This project will enhance our knowledge of how ageing impacts on the interpretation of visual and auditory information regarding the timing and location of ....Resolving multi-sensory conflict as we age: audio-visual integration and the role of normal and abnormal sensory decline. Australia has an ageing population. Even the healthiest older individuals undergo some deterioration of vision and hearing, however, these senses are almost invariably studied in isolation. The real world is multisensory. This project will enhance our knowledge of how ageing impacts on the interpretation of visual and auditory information regarding the timing and location of objects; essential precursors to many real world tasks, for example: driving, interpreting speech, and hazard avoidance. This knowledge is essential for the optimisation of audio-visual environments for the elderly, and for the development of tools to improve performance in the presence of sensory decline due to age-related eye disease.Read moreRead less
Understanding the consequences of normal ageing on visual form perception. Australia has an ageing population. Within the elderly, vision is a key sense that contributes significantly to the maintenance of independence, mobility and participation in society. This project will enhance our knowledge of the impact of ageing on vision. The research findings are important to a variety of disciplines involved in planning for our ageing population; for example: the design of living/working spaces for t ....Understanding the consequences of normal ageing on visual form perception. Australia has an ageing population. Within the elderly, vision is a key sense that contributes significantly to the maintenance of independence, mobility and participation in society. This project will enhance our knowledge of the impact of ageing on vision. The research findings are important to a variety of disciplines involved in planning for our ageing population; for example: the design of living/working spaces for the elderly, information technology, and the design of technology to assist with independent living. This project will train students in visual psychophysics, continuing the strong international reputation and output of Australian scientists in this discipline.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0452971
Funder
Australian Research Council
Funding Amount
$102,900.00
Summary
Optical imaging of brain activity: Studies of the neural basis of sensory perception, plasticity and behaviour. Basic to the understanding of the brain is to know how the overall architecture of the nervous system relates to its function. We propose to study this by directly visualising the regions that are functionally active in the living brains of animals, down to resolution limits of less than 100 micrometres. Such "optical imaging" will be done by recording light reflected from the surfac ....Optical imaging of brain activity: Studies of the neural basis of sensory perception, plasticity and behaviour. Basic to the understanding of the brain is to know how the overall architecture of the nervous system relates to its function. We propose to study this by directly visualising the regions that are functionally active in the living brains of animals, down to resolution limits of less than 100 micrometres. Such "optical imaging" will be done by recording light reflected from the surface of the brain, which in turn depends upon activity-dependent intrinsic signals (eg. degree of oxygenation of haemoglobin). These signals will be recorded by a special camera and amplified using the requested system.Read moreRead less
Promoting Regrowth Of Nerve Fibres Into The Epidermis During Diabetic Neuropathy By LRP Agonists
Funder
National Health and Medical Research Council
Funding Amount
$427,102.00
Summary
Nerve damage can develop post injury or disease and is often very debilitating, slow to heal and can cause increased pain. Our work aims to examine a new class of molecules that we show can activate selected fat-receptors on nerve cells to guide the growth of regenerating nerves. We will determine how these receptors function with the aim of developing a novel class of therapeutics directed at healing nerve damage.
Discovery Early Career Researcher Award - Grant ID: DE140101505
Funder
Australian Research Council
Funding Amount
$395,220.00
Summary
Visual computation in the primate brain: circuits for motion processing. This project will investigate the neural mechanism that mediates motion detection, a fundamental visual function. Although computational theories have been developed to explain how neurons can detect moving objects and patterns, it has been very difficult to investigate how (or if) the models are implemented in the visual cortex. This project will examine controversial aspects of current theories. Using innovative methods, ....Visual computation in the primate brain: circuits for motion processing. This project will investigate the neural mechanism that mediates motion detection, a fundamental visual function. Although computational theories have been developed to explain how neurons can detect moving objects and patterns, it has been very difficult to investigate how (or if) the models are implemented in the visual cortex. This project will examine controversial aspects of current theories. Using innovative methods, the project will characterise neurons connected in a motion detection circuit for the first time, as well as study how they function after a critical component in the circuit is shut off. The research will lead to a better understanding of how visual experience is created by the brain and will have implications in computer vision and bionics.Read moreRead less