Signaling Pathways To Enhance Potency Of AMPK-targeting Drugs
Funder
National Health and Medical Research Council
Funding Amount
$661,966.00
Summary
Sedentary lifestyles and consumption of high energy foods has led to epidemics of obesity-related metabolic diseases that place enormous financial and medical burden on the Australian economy. An attractive drug target to treat these diseases is AMP-activated protein kinase (AMPK) which functions as both a cellular fuel gauge and co-ordinator of whole-body metabolism. Our goal is to improve AMPK drug potency by identifying novel processes that sensitize AMPK to drugs.
Multimodal testing for a fast subcortical route for salient visual stimuli. This project aims to uncover links between underlying brain circuitry, uncertainty and consciousness, and perceptions of fear. The project will use a multi-modal combination of brain imaging and neural recording techniques to generate new knowledge about the brain’s processing of biologically relevant information. The expected outcomes will enhance our knowledge of how the brain rapidly and non-consciously prepares the ....Multimodal testing for a fast subcortical route for salient visual stimuli. This project aims to uncover links between underlying brain circuitry, uncertainty and consciousness, and perceptions of fear. The project will use a multi-modal combination of brain imaging and neural recording techniques to generate new knowledge about the brain’s processing of biologically relevant information. The expected outcomes will enhance our knowledge of how the brain rapidly and non-consciously prepares the body for potential escape behaviours and of the brain pathways engaged in fear perception. The outcomes have the potential to inform strategies for overcoming anxiety and its effects on daily life, social interactions and workplace productivity.Read moreRead less
A Structural Understanding Of Class B G Protein-coupled Receptor Function
Funder
National Health and Medical Research Council
Funding Amount
$1,289,570.00
Summary
G protein-coupled receptors (GPCRs) are the largest family of cell surface proteins that enable communication from external signals to the inside of cells of the body. Class B GPCRs are a therapeutically important subclass of these receptors and they play crucial roles in bone and energy homeostasis, cardiovascular control and immune response. This grant will uncover fundamental knowledge on how these receptors work, and will enhance future development of therapeutics.
Special Research Initiatives - Grant ID: SR0354793
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
A Neural Network: Understanding Brain Function. This proposal focuses on the mechanisms that regulate brain function, particularly those underpinning the changes in circuitry (plasticity) caused by altered inputs. As such, its core goal is to create an interface between researchers in the neurosciences, computational modelling, robotics and cognitive sciences in order to facilitate optimum collaborative interactions, identify key research questions and promote training opportunities across a mul ....A Neural Network: Understanding Brain Function. This proposal focuses on the mechanisms that regulate brain function, particularly those underpinning the changes in circuitry (plasticity) caused by altered inputs. As such, its core goal is to create an interface between researchers in the neurosciences, computational modelling, robotics and cognitive sciences in order to facilitate optimum collaborative interactions, identify key research questions and promote training opportunities across a multidisciplinary spectrum. This will drive an integrated and accelerated program of discovery and technological development, enhancing Australia's leadership in this crucial field and helping to highlight new biotechnology opportunities and capture social and economic benefits for the nation. Read moreRead less
Discovery And Development Of Better Pain Treatments
Funder
National Health and Medical Research Council
Funding Amount
$9,613,850.00
Summary
Many forms of pain remain poorly treated, leading to significant quality of life and economic losses. This Program grant will discover and characterise new peptides from cone snails and spiders that modulate specific channels in nerves that are critical to the transmission of pain signals to the brain. Using advanced chemical and structural approaches, promising leads will be optimised for potency and stability and evaluated in disease and pathway-specific models of pain to establish their clini ....Many forms of pain remain poorly treated, leading to significant quality of life and economic losses. This Program grant will discover and characterise new peptides from cone snails and spiders that modulate specific channels in nerves that are critical to the transmission of pain signals to the brain. Using advanced chemical and structural approaches, promising leads will be optimised for potency and stability and evaluated in disease and pathway-specific models of pain to establish their clinical potential.Read moreRead less
Sonification for complex, mission-critical work environments. Human operators must often pay attention to an immediate task while monitoring background information, but intrusive alarms often capture operators' attention inappropriately. We investigate how continuous auditory information ("sonification") can provide low-level background information when all is normal, yet capture attention to abnormalities only when needed. The results of three experiments will determine the most effective combi ....Sonification for complex, mission-critical work environments. Human operators must often pay attention to an immediate task while monitoring background information, but intrusive alarms often capture operators' attention inappropriately. We investigate how continuous auditory information ("sonification") can provide low-level background information when all is normal, yet capture attention to abnormalities only when needed. The results of three experiments will determine the most effective combination of visual and auditory information delivery; how well sonification captures attention when needed; and whether sonification captures attention to deviations from expected changes. Our findings will help establish principles of attentional mapping that significantly extend current approaches to interactive systems design.Read moreRead less
ARC Centre of Excellence - Vision Science. This Centre will generate important new knowledge of the performance, logic and stability of vision and visual behaviour. This knowledge will help reduce the burden of vision impairment in Australia, increasing productivity, promoting healthy ageing and reducing the community costs of visual impairment (ca. $9.85 billion in 2004). The knowledge produced will also make possible world-class innovations in robotics, leading to novel automated vision system ....ARC Centre of Excellence - Vision Science. This Centre will generate important new knowledge of the performance, logic and stability of vision and visual behaviour. This knowledge will help reduce the burden of vision impairment in Australia, increasing productivity, promoting healthy ageing and reducing the community costs of visual impairment (ca. $9.85 billion in 2004). The knowledge produced will also make possible world-class innovations in robotics, leading to novel automated vision systems with applications in industry and national security. Other knowledge will develop novel diagnostic technologies, for application in health delivery.Read moreRead less
Testing metabolic theories in ecology. There are striking similarities in the way plants and animals take up and use energy (metabolism), despite enormous variation in size and life-style. This project will make the first experimental comparison of the predictions of the two major theories for these broad patterns. The results will significantly progress this controversial and exciting field.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0882345
Funder
Australian Research Council
Funding Amount
$650,000.00
Summary
A 3.0 Tesla MRI system for human cognitive neuroscience research. For the first time scientists are beginning to reveal the complex relationship between human brain function and behaviour. These advances have stemmed almost exclusively from the development of sophisticated brain scanning techniques that provide high-resolution images of physiological changes associated with perceptual, cognitive and motor behaviours. This application seeks support for a state-of-the-art scanner to obtain high-re ....A 3.0 Tesla MRI system for human cognitive neuroscience research. For the first time scientists are beginning to reveal the complex relationship between human brain function and behaviour. These advances have stemmed almost exclusively from the development of sophisticated brain scanning techniques that provide high-resolution images of physiological changes associated with perceptual, cognitive and motor behaviours. This application seeks support for a state-of-the-art scanner to obtain high-resolution images of the brain as healthy adults perceive, think, learn, remember and decide. The facility will enable Australian scientists to understand the complex links between brain and behaviour in health and disease.Read moreRead less
Attentional asymmetries for navigation in healthy and clinical groups. This project plans to investigate how differences in attentional capacity between the left and right sides of the brain affect the ability to walk or manoeuvre vehicles between obstacles. To navigate our environment and avoid obstacles, we need to attend to stimuli that are important and ignore those that are not. Unfortunately, the brain’s attentional capacity is limited, which can result in errors and collisions. Using the ....Attentional asymmetries for navigation in healthy and clinical groups. This project plans to investigate how differences in attentional capacity between the left and right sides of the brain affect the ability to walk or manoeuvre vehicles between obstacles. To navigate our environment and avoid obstacles, we need to attend to stimuli that are important and ignore those that are not. Unfortunately, the brain’s attentional capacity is limited, which can result in errors and collisions. Using the techniques of cognitive neuroscience, the project aims to provide a better understanding of the cognitive and neural mechanisms that govern attention in an applied setting. It expects to identify the factors that exacerbate lapses in attention and collisions. The effect of everyday impediments such as mobile phones, alcohol and fatigue will be investigated together with means of minimising these attentional lapses and improving safety.Read moreRead less