Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0452971
Funder
Australian Research Council
Funding Amount
$102,900.00
Summary
Optical imaging of brain activity: Studies of the neural basis of sensory perception, plasticity and behaviour. Basic to the understanding of the brain is to know how the overall architecture of the nervous system relates to its function. We propose to study this by directly visualising the regions that are functionally active in the living brains of animals, down to resolution limits of less than 100 micrometres. Such "optical imaging" will be done by recording light reflected from the surfac ....Optical imaging of brain activity: Studies of the neural basis of sensory perception, plasticity and behaviour. Basic to the understanding of the brain is to know how the overall architecture of the nervous system relates to its function. We propose to study this by directly visualising the regions that are functionally active in the living brains of animals, down to resolution limits of less than 100 micrometres. Such "optical imaging" will be done by recording light reflected from the surface of the brain, which in turn depends upon activity-dependent intrinsic signals (eg. degree of oxygenation of haemoglobin). These signals will be recorded by a special camera and amplified using the requested system.Read moreRead less
The Role of Colour and Luminance in Spatial Location. How does the brain form our impression of the world? Black and white images appear normal to us. However, colour images without luminance variation have little depth, suggesting that the brain does not process colour in the same way as luminance. A series of fresh experiments examine how colour and luminance are utilised for seeing the depth and position of objects. The results will help us to understand how the first stages of visual process ....The Role of Colour and Luminance in Spatial Location. How does the brain form our impression of the world? Black and white images appear normal to us. However, colour images without luminance variation have little depth, suggesting that the brain does not process colour in the same way as luminance. A series of fresh experiments examine how colour and luminance are utilised for seeing the depth and position of objects. The results will help us to understand how the first stages of visual processing in the brain shape our sense of the world, and help develop theories of human vision, as well as animal and machine models of vision.Read moreRead less
My research focus is the physical and mental health of Australian women at midlife. Over the next 5 years I will address the management of severe menopausal symptoms, midlife depression and the neglected health needs of women during and after cancer treatment, organ transplant and severe persistent mental illness. I will also investigate novel treatment approaches for menopausal symptoms. I will work closely with relevant professional and community groups in planning, implementation and translat ....My research focus is the physical and mental health of Australian women at midlife. Over the next 5 years I will address the management of severe menopausal symptoms, midlife depression and the neglected health needs of women during and after cancer treatment, organ transplant and severe persistent mental illness. I will also investigate novel treatment approaches for menopausal symptoms. I will work closely with relevant professional and community groups in planning, implementation and translation to ensure my research addresses their needs.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE160100125
Funder
Australian Research Council
Funding Amount
$385,536.00
Summary
Human visual perception: Connecting genes, brain and behaviour. This project aims to reveal the relationship between genes, brain and behaviour in visual perception, where underlying brain activity can be decoded from electrical signals. Modern molecular genetics promises unprecedented insights into human psychology. But progress has been slower than expected because the brain mechanisms linking genes to behaviours are incredibly complex. Project results are expected to show how common variation ....Human visual perception: Connecting genes, brain and behaviour. This project aims to reveal the relationship between genes, brain and behaviour in visual perception, where underlying brain activity can be decoded from electrical signals. Modern molecular genetics promises unprecedented insights into human psychology. But progress has been slower than expected because the brain mechanisms linking genes to behaviours are incredibly complex. Project results are expected to show how common variations in genes affect our brain's response to visual stimulation, and how this in turn alters our perceptual experience and behavioural reactions. These discoveries aim to cast new light on the architecture and development of the mind, and provide a new model for investigating the genetic basis of other psychological traits.Read moreRead less
The effect of cochlear implants on cognitive decline in ageing Australians. This project aims to investigate the impact of cochlear implants on cognitive function in elderly people with deafness. Deafness has been found to be independently associated with a 30–40 per cent accelerated rate of cognitive decline in elderly adults. There is currently no effective treatment for cognitive decline. The intended outcomes of this observational study will help us to understand the biological process of co ....The effect of cochlear implants on cognitive decline in ageing Australians. This project aims to investigate the impact of cochlear implants on cognitive function in elderly people with deafness. Deafness has been found to be independently associated with a 30–40 per cent accelerated rate of cognitive decline in elderly adults. There is currently no effective treatment for cognitive decline. The intended outcomes of this observational study will help us to understand the biological process of cognitive decline, whether hearing loss is causal, and whether the process can be altered. These findings should be applicable to all individuals with hearing loss. If cochlear implants delay cognitive decline, this would significantly affect policy, quality of life for the elderly, and the cost to society.Read moreRead less
Functional imaging of colour pathways in the living eye. In order to repair or regenerate a diseased eye, we require knowledge of the normal pattern or nerve cell connections, and knowing how biology solves the problem of colour vision can be used to improve the design of artificial vision systems. The adaptive optics machine we will build in this project can be used to image nerve cells, fine blood vessels, and nerve fibre bundles in the normal and diseased eye. This will improve Australia's re ....Functional imaging of colour pathways in the living eye. In order to repair or regenerate a diseased eye, we require knowledge of the normal pattern or nerve cell connections, and knowing how biology solves the problem of colour vision can be used to improve the design of artificial vision systems. The adaptive optics machine we will build in this project can be used to image nerve cells, fine blood vessels, and nerve fibre bundles in the normal and diseased eye. This will improve Australia's research and development capacity in this new area of medical diagnostics. Our machine will be made available to other Australian laboratories and will improve the national capacity for making further scientific discoveries about how the visual system works.Read moreRead less
The Clinicial Centre Of Research Excellence At The Jean Hailes Foundation: For The Study Of Women's Health
Funder
National Health and Medical Research Council
Funding Amount
$2,000,000.00
Summary
The major health issues affecting women from the mid-reproductive years include depression, disorders of mood and sexual function, and breast cancer, with cardiovascular disease, osteoporosis, and osteoarthritis becoming increasingly prevalent with age. Linking each of these are their known or probable causal associations with oestrogens and androgens. This Centre will provide an opportunity for comprehensive and multidisciplinary research into the role of oestrogens and androgens in these disor ....The major health issues affecting women from the mid-reproductive years include depression, disorders of mood and sexual function, and breast cancer, with cardiovascular disease, osteoporosis, and osteoarthritis becoming increasingly prevalent with age. Linking each of these are their known or probable causal associations with oestrogens and androgens. This Centre will provide an opportunity for comprehensive and multidisciplinary research into the role of oestrogens and androgens in these disorders.Read moreRead less
Reducing fire deaths - a new approach to smoke alarms. Disturbingly, those most at risk of dying in residential fires are also least likely to awaken to the current smoke alarm signal, now mandatory in Australian residences. This project will develop a new alarm (using Gibsonian, naturalistic sounds and/or a voice signal) and compare its waking efficacy with the current smoke alarm. Testing will involve three vulnerable groups; sleep deprived young adults, children and alcohol intoxicated. The r ....Reducing fire deaths - a new approach to smoke alarms. Disturbingly, those most at risk of dying in residential fires are also least likely to awaken to the current smoke alarm signal, now mandatory in Australian residences. This project will develop a new alarm (using Gibsonian, naturalistic sounds and/or a voice signal) and compare its waking efficacy with the current smoke alarm. Testing will involve three vulnerable groups; sleep deprived young adults, children and alcohol intoxicated. The research is innovative with important implications for community public safety, the national and international smoke alarm industry, performance based models of building safety and our theoretical understanding of cognitive processing during sleep.Read moreRead less
An Examination Of Motor Functioning In Autism And Asperger's Disorder: An Analysis Of Gait & Cortical Brain Activity.
Funder
National Health and Medical Research Council
Funding Amount
$120,220.00
Summary
Autism is a developmental disorder characterised by a triad of deficits: delayed and atypical language development, impaired development of social skills, and ritualistic and stereotypic behaviour. Although not part of the standard diagnosis, movement disorders and gait abnormalities have been clinically observed in autism similar to those seen in Parkinson's disease. In addition, individuals with Asperger's disorder may appear more clumsy, have a stiff or awkward way of walking, and exhibit poo ....Autism is a developmental disorder characterised by a triad of deficits: delayed and atypical language development, impaired development of social skills, and ritualistic and stereotypic behaviour. Although not part of the standard diagnosis, movement disorders and gait abnormalities have been clinically observed in autism similar to those seen in Parkinson's disease. In addition, individuals with Asperger's disorder may appear more clumsy, have a stiff or awkward way of walking, and exhibit poor coordination in posture and gesture. It has been suggested that there is disruption within the basal-ganglia-thalamocortical circuitry (the region connecting the frontal and sub-cortical structures), which may cause the motor dysfunction seen in autism and Asperger's disorder. Few studies have attempted to isolate particular stages of motor functioning which may account for the coordination and motor delay observed clinically in autism and Asperger's disorder. A recent study of ours found evidence to suggest that motor planning deficiencies may account for the 'clumsy' movement patterns frequently reported in the autism - Asperger's disorder literature. Therefore, the aim of this research is to provide a comprehensive neurobehavioural and neurophysiological analysis of motor functioning in young people with autism and Asperger's disorder to further examine the exact stages of motor processing which are deficient in these disorder groups. Recent retrospective studies have shown that even as infants children with autism exhibit clear features of motor disturbance, which, if detected and clearly defined, could advance early diagnosis. In addition to advancing the clinical definition of autism and Asperger's disorder, a careful examination of motor disturbance may also illuminate the neurobiological underpinnings of these disorders.Read moreRead less
Special Research Initiatives - Grant ID: SR0354596
Funder
Australian Research Council
Funding Amount
$20,000.00
Summary
Perception and Action in Auditory Scenes (PAAS): Neural, Behavioural, Computational and Mechanical Systems. Auditory scenes are temporal and ephemeral yet pervasively influence human life. How humans negotiate such scenes has not been solved, a fact highlighted by attempts to build machines to respond to speech, warnings etc., in real-world situations with room reverberation, different talkers, and background noise. No one discipline can solve such problems. In this network outstanding researche ....Perception and Action in Auditory Scenes (PAAS): Neural, Behavioural, Computational and Mechanical Systems. Auditory scenes are temporal and ephemeral yet pervasively influence human life. How humans negotiate such scenes has not been solved, a fact highlighted by attempts to build machines to respond to speech, warnings etc., in real-world situations with room reverberation, different talkers, and background noise. No one discipline can solve such problems. In this network outstanding researchers from physical, medical, human, and social sciences with interests in speech, music and audition will provide insights into how humans and machines localize, recognize, interpret and produce auditory events, and advance frontier technologies, e.g., automatic speech recognition, hearing prostheses, auditory monitoring/warning systems.Read moreRead less