The role of the immune system in pain is emerging from recent discoveries, and may hold the key to novel pain treatments. Most people experience brief gut infections from food or contagion without long-term consequences. Many others suffer symptoms for years afterwards - probably the best example of immune-based pain. Our project investigates how immune cells communicate with sensory nerves, and how these communications change from both angles after gut infection or inflammation.
Transient Receptor Potential Channels (TRPs) As Transducers And Targets In Primary Visceral Afferents
Funder
National Health and Medical Research Council
Funding Amount
$669,130.00
Summary
Transient receptor potential, or TRP channels, are involved in generating many of the sensations we perceive, such as heat, cold, touch and pain. Some TRP channels are specialized to signal pain from visceral organs, which we must investigate if we are to find treatments for visceral pain, which are currently lacking.
Creating perceptual experts in Australia's policing and security agencies. This project aims to create the next generation of experts in Australia’s policing and national security agencies, by improving crime scene evidence interpretation. Agencies are under pressure to develop more rigorous training practices that go beyond mere intuition and tradition. This project will use a novel approach that directs learning toward the most diagnostic perceptual cues. Expected outcomes include a solid empi ....Creating perceptual experts in Australia's policing and security agencies. This project aims to create the next generation of experts in Australia’s policing and national security agencies, by improving crime scene evidence interpretation. Agencies are under pressure to develop more rigorous training practices that go beyond mere intuition and tradition. This project will use a novel approach that directs learning toward the most diagnostic perceptual cues. Expected outcomes include a solid empirical basis for national training programs designed to create experts that are accurate, reliable, and continuously improving. Improving the training of experts will ensure the integrity of forensics as evidentiary tools available to police, lead to more reliable courtroom convictions and help safeguard Australia from terrorism and crime.Read moreRead less
Attentional asymmetries for navigation in healthy and clinical groups. This project plans to investigate how differences in attentional capacity between the left and right sides of the brain affect the ability to walk or manoeuvre vehicles between obstacles. To navigate our environment and avoid obstacles, we need to attend to stimuli that are important and ignore those that are not. Unfortunately, the brain’s attentional capacity is limited, which can result in errors and collisions. Using the ....Attentional asymmetries for navigation in healthy and clinical groups. This project plans to investigate how differences in attentional capacity between the left and right sides of the brain affect the ability to walk or manoeuvre vehicles between obstacles. To navigate our environment and avoid obstacles, we need to attend to stimuli that are important and ignore those that are not. Unfortunately, the brain’s attentional capacity is limited, which can result in errors and collisions. Using the techniques of cognitive neuroscience, the project aims to provide a better understanding of the cognitive and neural mechanisms that govern attention in an applied setting. It expects to identify the factors that exacerbate lapses in attention and collisions. The effect of everyday impediments such as mobile phones, alcohol and fatigue will be investigated together with means of minimising these attentional lapses and improving safety.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE150101108
Funder
Australian Research Council
Funding Amount
$352,000.00
Summary
The ups and downs of visuospatial attention. The brain has a remarkable capacity to provide a coherent experience of the world by seamlessly integrating sights and sounds from different locations. It is only after brain damage, or when faced with a high attentional load, that our limitations become apparent. The project aims to investigate these limitations by determining how spatial location influences attention in relation to distractibility, cross-modal input and emotionality. Eye tracking an ....The ups and downs of visuospatial attention. The brain has a remarkable capacity to provide a coherent experience of the world by seamlessly integrating sights and sounds from different locations. It is only after brain damage, or when faced with a high attentional load, that our limitations become apparent. The project aims to investigate these limitations by determining how spatial location influences attention in relation to distractibility, cross-modal input and emotionality. Eye tracking and physiological measures of arousal will be combined with traditional cognitive measures to provide a deeper understanding of spatial attention. This project aims to improve attentional models and develop innovative strategies to increase safety by decreasing inattention and distraction.Read moreRead less
Closing the loop between salience and brain activity. This project aims to understand how animals exposed to an abundance of highly complex information decide what to attend to, that is, how they determine visual saliency. The project will approach this question by systematically tracking visual decision-making in the smallest animal brains, in closed-loop virtual reality environment. This approach will uncover basic working principles applicable to any system that needs to pay attention in a vi ....Closing the loop between salience and brain activity. This project aims to understand how animals exposed to an abundance of highly complex information decide what to attend to, that is, how they determine visual saliency. The project will approach this question by systematically tracking visual decision-making in the smallest animal brains, in closed-loop virtual reality environment. This approach will uncover basic working principles applicable to any system that needs to pay attention in a visually cluttered world, from insects to humans or autonomous vehicles.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC170100008
Funder
Australian Research Council
Funding Amount
$4,459,672.00
Summary
ARC Training Centre for Innovative Wine Production. The ARC Training Centre for Innovative Wine Production aims to tackle challenges to wine production through innovative, multi-disciplinary research. Australia’s grape and wine industry is a multi-billion dollar industry, yet in some areas profitability is low. Reasons include extreme weather events, soil salinity and diseases, inefficient practices, a low level of technological innovation and high input costs. New technologies and process effic ....ARC Training Centre for Innovative Wine Production. The ARC Training Centre for Innovative Wine Production aims to tackle challenges to wine production through innovative, multi-disciplinary research. Australia’s grape and wine industry is a multi-billion dollar industry, yet in some areas profitability is low. Reasons include extreme weather events, soil salinity and diseases, inefficient practices, a low level of technological innovation and high input costs. New technologies and process efficiencies developed as part of this project will reduce environmental impact, drive production costs down and profits and employment up. The project will mount a suite of industry-led projects to deliver outcomes to boost Australia’s competitiveness as a supplier of sustainably-produced premium branded wine to the world.Read moreRead less
The relative impacts of sleep, wake and the internal body clock on human performance. The 24h society presents a number of challenges to the shiftworker. First, shiftworkers have to maintain a balance between the competing needs of work, family, leisure and social life. Second, shiftwork has been identified as a risk factor for obesity, diabetes and heart disease. Third, shiftworkers have an increased risk of injury and death at work. This project will use an innovative research protocol to prov ....The relative impacts of sleep, wake and the internal body clock on human performance. The 24h society presents a number of challenges to the shiftworker. First, shiftworkers have to maintain a balance between the competing needs of work, family, leisure and social life. Second, shiftwork has been identified as a risk factor for obesity, diabetes and heart disease. Third, shiftworkers have an increased risk of injury and death at work. This project will use an innovative research protocol to provide critical information about the independent and combined effects of sleep loss and body clock disruption on human performance. Work schedules designed on the basis of a better understanding of sleep loss and circadian disruption will result in healthier employees, safer workplaces, and reduced costs to the community.Read moreRead less
Sleeping for Gold: The Influence of Sleep on the Sports Performance of Elite Athletes. The aim of this project is to improve the performance of Australia's elite athletes by enhancing the amount and quality of sleep that they obtain. This project will have three major benefits. First, successful role models will encourage more Australian children and adults to participate in sport. This is critical given that the incidence of obesity (a major risk factor for diabetes, cardiovascular disease and ....Sleeping for Gold: The Influence of Sleep on the Sports Performance of Elite Athletes. The aim of this project is to improve the performance of Australia's elite athletes by enhancing the amount and quality of sleep that they obtain. This project will have three major benefits. First, successful role models will encourage more Australian children and adults to participate in sport. This is critical given that the incidence of obesity (a major risk factor for diabetes, cardiovascular disease and some cancers) has doubled in Australia in the last 15 years as participation in sport has dropped. Second, the success of our elite athletes will provide a source of pride in our achievements as a nation. Third, this research will enable the Australian Institute of Sport to remain as an international leader in sports science research.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100035
Funder
Australian Research Council
Funding Amount
$1,205,137.00
Summary
Founding an Australian Critical Zone Observatory Network. This proposal founds a new network of Australian Critical Zone Observatories. The network will fill essential knowledge gaps about interactions of under- and above-ground environmental processes and their responses to disturbance and change. These interactions determine the sustainability of food, clean water, mineral resources and Australian ecosystems, and cannot be studied with existing environmental infrastructure. The 5 foundation ....Founding an Australian Critical Zone Observatory Network. This proposal founds a new network of Australian Critical Zone Observatories. The network will fill essential knowledge gaps about interactions of under- and above-ground environmental processes and their responses to disturbance and change. These interactions determine the sustainability of food, clean water, mineral resources and Australian ecosystems, and cannot be studied with existing environmental infrastructure. The 5 foundational sites will host integrated monitoring equipment to observe stocks and fluxes of carbon, water, energy and mass across the “Critical Zone” – the vertical span from plant canopies to fresh bedrock. Joining a burgeoning international movement, the network will catalyse Critical Zone science in Australia.Read moreRead less