The role of the immune system in pain is emerging from recent discoveries, and may hold the key to novel pain treatments. Most people experience brief gut infections from food or contagion without long-term consequences. Many others suffer symptoms for years afterwards - probably the best example of immune-based pain. Our project investigates how immune cells communicate with sensory nerves, and how these communications change from both angles after gut infection or inflammation.
Probing cross modal interactions in the perception of object motion and self-motion. How the brain integrates information from the different senses is not yet understood. This project aims first, to uncover how the brain integrates sound and visual information when perceiving moving objects and second, to probe more complex sensory interactions between sound, vision, and our vestibular senses when perceiving self-motion. This project will expand Australia's knowledge base, strengthen collabora ....Probing cross modal interactions in the perception of object motion and self-motion. How the brain integrates information from the different senses is not yet understood. This project aims first, to uncover how the brain integrates sound and visual information when perceiving moving objects and second, to probe more complex sensory interactions between sound, vision, and our vestibular senses when perceiving self-motion. This project will expand Australia's knowledge base, strengthen collaborative ties between Australia and Japan, and provide unique training opportunities for Australian and Japanese students. Publication of research in top-ranking journals will further promote Australian science abroad. Results will lead to improvements in the design of human-machine interfaces in both industry and entertainment.Read moreRead less
How do bees orchestrate smooth landings? The results should pave the way for the development of novel, biologically inspired strategies for the control of landing in unmanned aerial vehicles. Endowing aircraft with the capability of autonomous flight and landing has been a major challenge in engineering technology. There is now considerable interest, nationally and world wide, in the development of small, intelligent, autonomous airborne vehicles for application in a number of areas of defense, ....How do bees orchestrate smooth landings? The results should pave the way for the development of novel, biologically inspired strategies for the control of landing in unmanned aerial vehicles. Endowing aircraft with the capability of autonomous flight and landing has been a major challenge in engineering technology. There is now considerable interest, nationally and world wide, in the development of small, intelligent, autonomous airborne vehicles for application in a number of areas of defense, surveillance and space exploration. The proposed research will help Australia maintain a leading edge in uncovering important biological principles of flight control that can be translated into useful technological applications.Read moreRead less
Motion and Spatial Coding in Vision. The results of this project will have implications for the design and implementation of artificial visual systems. Completion of this project will depend upon international collaboration - forging links between a young Australian investigator and outstanding overseas scientists as well as providing excellent training opportunities. Subsequent publication of the research in top-ranking international journals will further promote Australian science abroad.
Rod-cone interaction under mesopic illumination. Visual function and performance can be degraded under dim light levels. This occurs in many indoor settings, emergency and traffic lighting conditions. Approximately 45% of all Australian traffic fatalities occur under dim light. The research program uses a frontier technology to determine how vision is degraded under dim lighting and provide accurate parameters to better design mesopic lighting environments to maximize visual function and perform ....Rod-cone interaction under mesopic illumination. Visual function and performance can be degraded under dim light levels. This occurs in many indoor settings, emergency and traffic lighting conditions. Approximately 45% of all Australian traffic fatalities occur under dim light. The research program uses a frontier technology to determine how vision is degraded under dim lighting and provide accurate parameters to better design mesopic lighting environments to maximize visual function and performance. This work will help to evaluate new energy-efficient lighting systems and optimise traffic lighting for early recognition of obstacles and dangerous situations. Read moreRead less
Psychophysical Assessment of Receptoral and Post-Receptoral Visual Function. Visual function and performance can be degraded under dim light levels. This occurs in many indoor settings, emergency lighting and road traffic lighting conditions. Approximately 45% of all Australian road traffic fatalities occur under dim lighting conditions. My data will be unique, as it will provide accurate parameters to better design mesopic lighting environments to maximize visual function and performance. This ....Psychophysical Assessment of Receptoral and Post-Receptoral Visual Function. Visual function and performance can be degraded under dim light levels. This occurs in many indoor settings, emergency lighting and road traffic lighting conditions. Approximately 45% of all Australian road traffic fatalities occur under dim lighting conditions. My data will be unique, as it will provide accurate parameters to better design mesopic lighting environments to maximize visual function and performance. This work will help to optimise road traffic lighting for the early recognition of obstacles and dangerous situations. The research program will make important scientific contributions to understanding human visual function and performance at dim light levels.Read moreRead less
The rules governing combined rod and cone photoreceptor signalling in visual pathways. The research program investigates vision at dim (mesopic) light levels where rod and cone photoreceptors simultaneously transmit visual information. The interaction between rod and cone signals is not trivial because their different amplitudes, timings and delays significantly change the perceptual qualities of our visual experience. The research addresses fundamental questions about how the retina and brain i ....The rules governing combined rod and cone photoreceptor signalling in visual pathways. The research program investigates vision at dim (mesopic) light levels where rod and cone photoreceptors simultaneously transmit visual information. The interaction between rod and cone signals is not trivial because their different amplitudes, timings and delays significantly change the perceptual qualities of our visual experience. The research addresses fundamental questions about how the retina and brain integrate disparate signals from the rods and cones to produce a homogenous visual percept. New psychophysical and electroretinographic paradigms will independently control the retinal photoreceptors to resolve the long standing problem of how noise modifies signalling and information flow between the retina and visual cortex.Read moreRead less
Melanopsin function in humans. This project aims to understand melanopsin signalling in humans. A newly discovered retinal ganglion cell class expresses the melanopsin photopigment. Melanopsin signalling controls neural functions for light dependent image formation and non-image forming processes. Many of these are unknown in humans. This project will use a 5-primary photostimulator to define how melanopsin controls these processes in humans. The outcomes are expected to advance understanding of ....Melanopsin function in humans. This project aims to understand melanopsin signalling in humans. A newly discovered retinal ganglion cell class expresses the melanopsin photopigment. Melanopsin signalling controls neural functions for light dependent image formation and non-image forming processes. Many of these are unknown in humans. This project will use a 5-primary photostimulator to define how melanopsin controls these processes in humans. The outcomes are expected to advance understanding of human vision. This could provide avenues for using light to increase active participation in society and improve health and well-being, and strategies to assess human vision and the body’s internal clock.Read moreRead less
Multimodal testing for a fast subcortical route for salient visual stimuli. This project aims to uncover links between underlying brain circuitry, uncertainty and consciousness, and perceptions of fear. The project will use a multi-modal combination of brain imaging and neural recording techniques to generate new knowledge about the brain’s processing of biologically relevant information. The expected outcomes will enhance our knowledge of how the brain rapidly and non-consciously prepares the ....Multimodal testing for a fast subcortical route for salient visual stimuli. This project aims to uncover links between underlying brain circuitry, uncertainty and consciousness, and perceptions of fear. The project will use a multi-modal combination of brain imaging and neural recording techniques to generate new knowledge about the brain’s processing of biologically relevant information. The expected outcomes will enhance our knowledge of how the brain rapidly and non-consciously prepares the body for potential escape behaviours and of the brain pathways engaged in fear perception. The outcomes have the potential to inform strategies for overcoming anxiety and its effects on daily life, social interactions and workplace productivity.Read moreRead less
Dendritic information processing during sensory-motor behaviour. The neocortex is centrally involved in the control of animal behaviour. It is largely unknown how neocortical neurons contribute to the neuronal computations that generate behaviour. The project will study how individual neurons in the neocortex compute the sensory and motor signals that underlie an important exploratory behaviour in rodents.