The Role Of Adipokines In Modulation Of Gastric Vagal Afferent Satiety Signals
Funder
National Health and Medical Research Council
Funding Amount
$624,535.00
Summary
When we feel full after a meal it is the result of a variety of different nerve signals from the gut in response to distension of the stomach and specific nutrients. These signals are disordered in obesity and may be influenced by factors released from fat stores in the body. The aim of this project is to determine how these factors interact with gastric nerve satiety signals and thus identify targets for the pharmacological treatment of obesity.
The role of the immune system in pain is emerging from recent discoveries, and may hold the key to novel pain treatments. Most people experience brief gut infections from food or contagion without long-term consequences. Many others suffer symptoms for years afterwards - probably the best example of immune-based pain. Our project investigates how immune cells communicate with sensory nerves, and how these communications change from both angles after gut infection or inflammation.
Estimating And Alleviating The Impacts Of Age-Related Sensory Decline
Funder
National Health and Medical Research Council
Funding Amount
$323,767.00
Summary
Sensory loss and dementia disproportionately affect older adults, often co-occur, and are the two leading contributors to disability burden among older Australians. This research will investigate the consequences that hearing and vision loss have for older adult health and wellbeing, informing strategies to reduce the disability burden of age-related sensory loss. These impacts include cognitive decline and dementia, mental health, quality of life, disability and independent living.
Transient Receptor Potential Channels (TRPs) As Transducers And Targets In Primary Visceral Afferents
Funder
National Health and Medical Research Council
Funding Amount
$669,130.00
Summary
Transient receptor potential, or TRP channels, are involved in generating many of the sensations we perceive, such as heat, cold, touch and pain. Some TRP channels are specialized to signal pain from visceral organs, which we must investigate if we are to find treatments for visceral pain, which are currently lacking.
Ion Channels Underlying Inflammatory And Post-inflammatory Visceral Mechanical Hypersensitivity
Funder
National Health and Medical Research Council
Funding Amount
$453,439.00
Summary
Inflammation causes tissue damage that triggers ion channels within sensory nerve fibres to produce greater signals in response to mechanical events, causing acute pain. In chronic pain, although the inflamed tissue has healed, sensory nerve fibres fail to "reset" back to normal. Often chronic pain is more severe than acute pain. This project will identify which ion channels are responsible for signalling acute and chronic visceral pain, explaining why sensory nerve fibres fail to reset.
SENSORIMOTOR AND AUTONOMIC DYSREGULATION IN HEREDITARY SENSORY AND AUTONOMIC NEUROPATHIES
Funder
National Health and Medical Research Council
Funding Amount
$50,406.00
Summary
Specific genetic mutations can lead to widespread changes in the body. Here we are looking at the congenital Hereditary and Sensory Autonomic Neuropathies, the most common of which primarily affects Eastern European Jews. Affected individuals have difficulty walking and controlling their blood pressure, and also have an indifference to pain. This series of experiments aims to increase our understanding of the underlying neurophysiological disturbances.
The Role Of Corticothalamic Feedback On The Response Dynamics Of Thalamic Neurons
Funder
National Health and Medical Research Council
Funding Amount
$351,852.00
Summary
A fundamental question in neuroscience is how the brain selectively processes sensory information to generate a reliable representation of the world. Positioned in the centre of the brain, the thalamus plays a key role in sensory processing. This project investigates how the interaction between thalamus and cortex shapes the selection and gating of sensory information. This is a fundamental question in basic neuroscience with the potential to increase our knowledge about attentional deficits.
The effect of multisensory and sensory-motor training on auditory accommodation. Learning to use a hearing aid or cochlear implant requires the brain to make adaptive changes to the new type of sensory information provided to the ears. This project examines what drives this accommodation and how we may accelerate the process and maximise its benefits by training so that listeners are able to make better use of these devices.
Discovery Early Career Researcher Award - Grant ID: DE190100136
Funder
Australian Research Council
Funding Amount
$385,288.00
Summary
The influence of naturalistic context on visual short-term memory. This project aims to understand visual short-term memory in natural visual environments using a combination of behavioural and brain data. Visual short-term memory is thought to be critical to complex cognitive tasks such as learning and problem solving, but how low-level image context and high-level semantic information influence short-term memory is poorly understood. This project will use advanced computational image processin ....The influence of naturalistic context on visual short-term memory. This project aims to understand visual short-term memory in natural visual environments using a combination of behavioural and brain data. Visual short-term memory is thought to be critical to complex cognitive tasks such as learning and problem solving, but how low-level image context and high-level semantic information influence short-term memory is poorly understood. This project will use advanced computational image processing tools, neuro-imaging, and psychophysical experiments to provide a comprehensive analysis of short-term memory in naturalistic images. The expected outcome is a better understanding of the neural bottlenecks that limit short-term memory, and a model that predicts memory constraints in natural visual environments.Read moreRead less
How human vision separately determines object and scene motion. This project aims to enhance understanding of how people process visual scenes containing multiple moving objects of interest. The project intends to measure human visual performance to determine how the brain processes multiple motion signals simultaneously. Expected outcomes include an increased understanding of how we are able to use an evolving visual scene to distinguish between changes due to self-motion and those due to the m ....How human vision separately determines object and scene motion. This project aims to enhance understanding of how people process visual scenes containing multiple moving objects of interest. The project intends to measure human visual performance to determine how the brain processes multiple motion signals simultaneously. Expected outcomes include an increased understanding of how we are able to use an evolving visual scene to distinguish between changes due to self-motion and those due to the motion of multiple moving objects such as crowded city footpaths and busy roads. The results will improve our understanding of failures to see moving objects in challenging viewing conditions (for example, high density traffic), and inform work in the design of autonomous driving and augmented reality display systems.Read moreRead less