Colour vision in marsupials. The ability to distinguish colours is a crucial aspect of vision, providing vital data for sexual selection, predator detection and food acquisition. Studies of mammalian colour vision have largely overlooked marsupials. Our recent investigation of spectral sensitivity in two Australian species revealed a colour discrimination capacity beyond that of placentals (excluding primates), implying disparate evolutionary pressures in the two groups. We will provide the fi ....Colour vision in marsupials. The ability to distinguish colours is a crucial aspect of vision, providing vital data for sexual selection, predator detection and food acquisition. Studies of mammalian colour vision have largely overlooked marsupials. Our recent investigation of spectral sensitivity in two Australian species revealed a colour discrimination capacity beyond that of placentals (excluding primates), implying disparate evolutionary pressures in the two groups. We will provide the first comprehensive description of colour vision in marsupials, studying species with differing rhythmicities, habitats and diets. Wavelength sensitivity and molecular structure of retinal visual pigments will be assessed in relation to evolutionary influences and ecological demands.
Read moreRead less
Using shape change for object perception: human and artificial vision. This project aims to examine the steps taken by the visual system to code the shape of objects, including those that change shape over time. The project seeks to employ experiments assessing human vision and machine learning techniques to examine these codes and, in particular, focus on the advantages of a system that exaggerates shape change over time. Expected outcomes include an improved shape code based on superior human ....Using shape change for object perception: human and artificial vision. This project aims to examine the steps taken by the visual system to code the shape of objects, including those that change shape over time. The project seeks to employ experiments assessing human vision and machine learning techniques to examine these codes and, in particular, focus on the advantages of a system that exaggerates shape change over time. Expected outcomes include an improved shape code based on superior human performance that can have many applications in automated visual systems. This project can directly benefit the animation industries where the creation of realistic movement of humans and animals remains a computationally intensive challenge.Read moreRead less
Neural metrics for space time and numerosity. What we propose is ground-breaking research. It will increase Australia's international competitiveness is science, expand the knowledge base of brain function and psychology and provide valuable training for research scientists.
Evolution and function of colour vision in mammals. The project aims to investigate colour vision in marsupials and monotremes (echidna and platypus) with differing phylogenies and biogeographic histories. Improving knowledge of the molecular structure of opsin genes mediating colour vision will be crucial to the understanding of evolution and function of this key mammalian (including human) sensory capacity. Understanding species colour discrimination will contribute to protective measures of ....Evolution and function of colour vision in mammals. The project aims to investigate colour vision in marsupials and monotremes (echidna and platypus) with differing phylogenies and biogeographic histories. Improving knowledge of the molecular structure of opsin genes mediating colour vision will be crucial to the understanding of evolution and function of this key mammalian (including human) sensory capacity. Understanding species colour discrimination will contribute to protective measures of Australia's unique fauna, presenting social and economic assets for the local and national community, and will set a standard that should be applied world-wide. Close international links and intellectual exchange will be invaluable to the Australian science community, including students.
Read moreRead less
Resolving multi-sensory conflict as we age: audio-visual integration and the role of normal and abnormal sensory decline. Australia has an ageing population. Even the healthiest older individuals undergo some deterioration of vision and hearing, however, these senses are almost invariably studied in isolation. The real world is multisensory. This project will enhance our knowledge of how ageing impacts on the interpretation of visual and auditory information regarding the timing and location of ....Resolving multi-sensory conflict as we age: audio-visual integration and the role of normal and abnormal sensory decline. Australia has an ageing population. Even the healthiest older individuals undergo some deterioration of vision and hearing, however, these senses are almost invariably studied in isolation. The real world is multisensory. This project will enhance our knowledge of how ageing impacts on the interpretation of visual and auditory information regarding the timing and location of objects; essential precursors to many real world tasks, for example: driving, interpreting speech, and hazard avoidance. This knowledge is essential for the optimisation of audio-visual environments for the elderly, and for the development of tools to improve performance in the presence of sensory decline due to age-related eye disease.Read moreRead less
Colour vision in birds: consequences to fatal collisions with wind farms. Wind-farms represent a key component of sustainable energy generation world-wide. However, many birds die as a result of collisions with wind-farms, posing an unsolved and controversial conservation issue. The proliferation of wind-farms in Australia will exacerbate the problem. Birds rely on vision to negotiate static and moving objects. Wind-farms, currently coloured to meet human aesthetic criteria, may be 'invisible' t ....Colour vision in birds: consequences to fatal collisions with wind farms. Wind-farms represent a key component of sustainable energy generation world-wide. However, many birds die as a result of collisions with wind-farms, posing an unsolved and controversial conservation issue. The proliferation of wind-farms in Australia will exacerbate the problem. Birds rely on vision to negotiate static and moving objects. Wind-farms, currently coloured to meet human aesthetic criteria, may be 'invisible' to birds since they see colours differently from humans. We will determine bird spectral sensitivities and compare them to the spectral reflectance of wind-farms. We will then develop modifications improving the visibility of wind-farms to birds, thereby reducing fatalities.Read moreRead less
Characterising and linking intermediate-level processing of pattern, motion and position in human vision? This work will advance basic science by enhancing understanding of human coding of image structure. The aim is to provide a common structure for understanding visual processing of form, motion and position. The work will help lift the international profile of Australian science. Explaining how the primitives for shape perception are extracted will also have consequences of potential economic ....Characterising and linking intermediate-level processing of pattern, motion and position in human vision? This work will advance basic science by enhancing understanding of human coding of image structure. The aim is to provide a common structure for understanding visual processing of form, motion and position. The work will help lift the international profile of Australian science. Explaining how the primitives for shape perception are extracted will also have consequences of potential economic benefit. One important aspect is the design of displays that allow observers to absorb complex information about rapidly changing situations. This work has the potential to provide information that enables display designers to optimise the efficiency of presentation of pattern and motion information.Read moreRead less
How the human visual system uses pattern information to organize motion. This project is an investigation into human vision, a priority area for ARC. Its aim is to discover how photons from moving objects leave traces in the human visual system that assist it to determine the path of local motion and the structure of global motion. Its theoretical significance is that it will lead to substantial revisions of current models of human visual processing. Its practical significance is that it will pr ....How the human visual system uses pattern information to organize motion. This project is an investigation into human vision, a priority area for ARC. Its aim is to discover how photons from moving objects leave traces in the human visual system that assist it to determine the path of local motion and the structure of global motion. Its theoretical significance is that it will lead to substantial revisions of current models of human visual processing. Its practical significance is that it will provide a theoretical basis for the design of display systems that are more effective in conveying information about motion to human observers and eliminate errors inherent in existing systems.Read moreRead less
Applying the Psychologist's Microelectrode to High-Level Vision: What face aftereffects can tell us about face processing. Aftereffects, the psychologist's microelectrode, can show how our visual experience relates to neural activity. In the well-known waterfall illusion, neurons coding downwards motion become fatigued while watching a waterfall, making stationary objects on the riverbank appear to move upwards. Viewing a face for a few seconds can have a similar effect, causing a previously ....Applying the Psychologist's Microelectrode to High-Level Vision: What face aftereffects can tell us about face processing. Aftereffects, the psychologist's microelectrode, can show how our visual experience relates to neural activity. In the well-known waterfall illusion, neurons coding downwards motion become fatigued while watching a waterfall, making stationary objects on the riverbank appear to move upwards. Viewing a face for a few seconds can have a similar effect, causing a previously neutral or average face to take on the opposite identity. Here we explore what this and other face afterffects can tell us about how faces are coded in high level vision.Read moreRead less
Characterization Of Novel Regulators Of Erythropoiesis
Funder
National Health and Medical Research Council
Funding Amount
$437,545.00
Summary
Mature red and white blood cells develop from hemopoietic stem cells in the adult bone marrow. The production of red blood cells is primarily controlled by the hormone erythropoietin (epo). The availability of this hormone in a recombinant form has aided in the treatment of numerous forms of anaemia resulting from kidney failure, malignancies, and AIDS. Previously we had identified that the protein Lyn must be present inside primitive red blood cells for epo to stimulate them to become mature fu ....Mature red and white blood cells develop from hemopoietic stem cells in the adult bone marrow. The production of red blood cells is primarily controlled by the hormone erythropoietin (epo). The availability of this hormone in a recombinant form has aided in the treatment of numerous forms of anaemia resulting from kidney failure, malignancies, and AIDS. Previously we had identified that the protein Lyn must be present inside primitive red blood cells for epo to stimulate them to become mature functional cells. We have identified six molecules which interact with Lyn in red blood cells. We have shown that amolecule called HS1 is important for epo function in individual red blood cells and now we plan to investigate its functions in whole animals, including mice that lack the HS1 gene. We have also shown that a molecule called Trip1 is important for red blood cell development. Interestingly, this molecule also interacts with the thyroid hormone receptor and can influence the effects of epo and thyroid hormone on red blood cell development. The interplay between these two hormones will be looked at in more detail both at the cell and whole animal levels in normal mice and those lacking the thyroid hormone receptor gene. The third Lyn binding molecule we isolated is a novel gene-we have named it ankyrin repeat protein in line with the molecules it is related to. This gene is expressed in red blood cells and we aim to investigate what role it plays in the development of these cells. The fourth gene is also novel and is closely related to another called AFAP-110, which can exert effects on the structure of a cell. Its role in red blood cell structure will also be investigated. Finally, the last two molecule we have identified are both novel and are unrelated to any other known proteins. As above, the effects of these two molecules on red blood cell development will be investigated.Read moreRead less