Local Sleep In The Awake Brain: An Underlying Cause Of Neurobehavioural Deficits In Sleep Apnea?
Funder
National Health and Medical Research Council
Funding Amount
$582,330.00
Summary
Obstructive sleep apnea (OSA) is a common sleep disorder which significantly impacts daytime functioning leading to excessive sleepiness, and problems with attention and thinking. Currently, the causes for cognitive impairment in OSA (including attentional lapses and performance deficits) are poorly understood. In the awake state, groups of neurons can briefly go “offline” as they do in sleep. These periods of “local sleep” may explain impaired task performance in OSA.
Transdermal Testosterone Therapy: A Potential Treatment For Selective Serotonin Reuptake Inhibitor (SSRI)-associated Sexual Dysfunction In Women
Funder
National Health and Medical Research Council
Funding Amount
$241,351.00
Summary
Female sexual dysfunction (FSD) is frequently reported with selective serotonin reuptake inhibitor (SSRI) therapy and venlafaxine, these being the most common antidepressants used by Australian women. We have shown that testosterone therapy significantly improves sexual function in women with FSD. However SSRI-users have been excluded from these past studies. The aim of this study is to assess the efficacy of transdermal testosterone therapy for treatment of sexual dysfunction associated with SS ....Female sexual dysfunction (FSD) is frequently reported with selective serotonin reuptake inhibitor (SSRI) therapy and venlafaxine, these being the most common antidepressants used by Australian women. We have shown that testosterone therapy significantly improves sexual function in women with FSD. However SSRI-users have been excluded from these past studies. The aim of this study is to assess the efficacy of transdermal testosterone therapy for treatment of sexual dysfunction associated with SSRI therapy.Read moreRead less
A Nurse Led Psychosocial Intervention With Peer Support To Reduce Needs In Women Being Treated With Radiotherapy For Gynaecological Cancer: A RCT
Funder
National Health and Medical Research Council
Funding Amount
$1,184,630.00
Summary
This study is to test the effectiveness of a nurse-led psychosocial intervention with peer support to reduce psychological distress, psychosocial needs, psychosexual difficulties and symptom distress and to improve quality of life and preparation for treatment of women receiving radiotherapy with curative intent for gynaecological cancer (GC) using a randomised controlled trial (RCT).
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0452971
Funder
Australian Research Council
Funding Amount
$102,900.00
Summary
Optical imaging of brain activity: Studies of the neural basis of sensory perception, plasticity and behaviour. Basic to the understanding of the brain is to know how the overall architecture of the nervous system relates to its function. We propose to study this by directly visualising the regions that are functionally active in the living brains of animals, down to resolution limits of less than 100 micrometres. Such "optical imaging" will be done by recording light reflected from the surfac ....Optical imaging of brain activity: Studies of the neural basis of sensory perception, plasticity and behaviour. Basic to the understanding of the brain is to know how the overall architecture of the nervous system relates to its function. We propose to study this by directly visualising the regions that are functionally active in the living brains of animals, down to resolution limits of less than 100 micrometres. Such "optical imaging" will be done by recording light reflected from the surface of the brain, which in turn depends upon activity-dependent intrinsic signals (eg. degree of oxygenation of haemoglobin). These signals will be recorded by a special camera and amplified using the requested system.Read moreRead less
The Role of Colour and Luminance in Spatial Location. How does the brain form our impression of the world? Black and white images appear normal to us. However, colour images without luminance variation have little depth, suggesting that the brain does not process colour in the same way as luminance. A series of fresh experiments examine how colour and luminance are utilised for seeing the depth and position of objects. The results will help us to understand how the first stages of visual process ....The Role of Colour and Luminance in Spatial Location. How does the brain form our impression of the world? Black and white images appear normal to us. However, colour images without luminance variation have little depth, suggesting that the brain does not process colour in the same way as luminance. A series of fresh experiments examine how colour and luminance are utilised for seeing the depth and position of objects. The results will help us to understand how the first stages of visual processing in the brain shape our sense of the world, and help develop theories of human vision, as well as animal and machine models of vision.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE160100125
Funder
Australian Research Council
Funding Amount
$385,536.00
Summary
Human visual perception: Connecting genes, brain and behaviour. This project aims to reveal the relationship between genes, brain and behaviour in visual perception, where underlying brain activity can be decoded from electrical signals. Modern molecular genetics promises unprecedented insights into human psychology. But progress has been slower than expected because the brain mechanisms linking genes to behaviours are incredibly complex. Project results are expected to show how common variation ....Human visual perception: Connecting genes, brain and behaviour. This project aims to reveal the relationship between genes, brain and behaviour in visual perception, where underlying brain activity can be decoded from electrical signals. Modern molecular genetics promises unprecedented insights into human psychology. But progress has been slower than expected because the brain mechanisms linking genes to behaviours are incredibly complex. Project results are expected to show how common variations in genes affect our brain's response to visual stimulation, and how this in turn alters our perceptual experience and behavioural reactions. These discoveries aim to cast new light on the architecture and development of the mind, and provide a new model for investigating the genetic basis of other psychological traits.Read moreRead less
A Trial Of A Multidisciplinary, Group Based Intervention To Meet The Needs Of Men With Prostate Cancer
Funder
National Health and Medical Research Council
Funding Amount
$524,285.00
Summary
This study will test an innovative approach to meeting the physical and psychosocial needs of men with early stage prostate cancer using a randomised controlled trial. This novel approach involves a combination of individual and group-based consultations which encourages peer-to-peer support, promotes self-care and enhances appropriate multidisciplinary referrals and communication. It provides a new model of care for patients with chronic diseases that can be translated into clinical practice.
The effect of cochlear implants on cognitive decline in ageing Australians. This project aims to investigate the impact of cochlear implants on cognitive function in elderly people with deafness. Deafness has been found to be independently associated with a 30–40 per cent accelerated rate of cognitive decline in elderly adults. There is currently no effective treatment for cognitive decline. The intended outcomes of this observational study will help us to understand the biological process of co ....The effect of cochlear implants on cognitive decline in ageing Australians. This project aims to investigate the impact of cochlear implants on cognitive function in elderly people with deafness. Deafness has been found to be independently associated with a 30–40 per cent accelerated rate of cognitive decline in elderly adults. There is currently no effective treatment for cognitive decline. The intended outcomes of this observational study will help us to understand the biological process of cognitive decline, whether hearing loss is causal, and whether the process can be altered. These findings should be applicable to all individuals with hearing loss. If cochlear implants delay cognitive decline, this would significantly affect policy, quality of life for the elderly, and the cost to society.Read moreRead less
Functional imaging of colour pathways in the living eye. In order to repair or regenerate a diseased eye, we require knowledge of the normal pattern or nerve cell connections, and knowing how biology solves the problem of colour vision can be used to improve the design of artificial vision systems. The adaptive optics machine we will build in this project can be used to image nerve cells, fine blood vessels, and nerve fibre bundles in the normal and diseased eye. This will improve Australia's re ....Functional imaging of colour pathways in the living eye. In order to repair or regenerate a diseased eye, we require knowledge of the normal pattern or nerve cell connections, and knowing how biology solves the problem of colour vision can be used to improve the design of artificial vision systems. The adaptive optics machine we will build in this project can be used to image nerve cells, fine blood vessels, and nerve fibre bundles in the normal and diseased eye. This will improve Australia's research and development capacity in this new area of medical diagnostics. Our machine will be made available to other Australian laboratories and will improve the national capacity for making further scientific discoveries about how the visual system works.Read moreRead less
Reducing fire deaths - a new approach to smoke alarms. Disturbingly, those most at risk of dying in residential fires are also least likely to awaken to the current smoke alarm signal, now mandatory in Australian residences. This project will develop a new alarm (using Gibsonian, naturalistic sounds and/or a voice signal) and compare its waking efficacy with the current smoke alarm. Testing will involve three vulnerable groups; sleep deprived young adults, children and alcohol intoxicated. The r ....Reducing fire deaths - a new approach to smoke alarms. Disturbingly, those most at risk of dying in residential fires are also least likely to awaken to the current smoke alarm signal, now mandatory in Australian residences. This project will develop a new alarm (using Gibsonian, naturalistic sounds and/or a voice signal) and compare its waking efficacy with the current smoke alarm. Testing will involve three vulnerable groups; sleep deprived young adults, children and alcohol intoxicated. The research is innovative with important implications for community public safety, the national and international smoke alarm industry, performance based models of building safety and our theoretical understanding of cognitive processing during sleep.Read moreRead less