Vision and lighting in the age of melanopsin. This project aims to develop innovative new technologies, which will advance understanding of the effects of light on human behavior mediated via the recently discovered melanopsin photopigment in the eye. The project expects to create a cutting-edge visual display technology, which will deliver the foundation knowledge of melanopsin shapes visual perception. The project will redefine current knowledge of human vision and provide a practical lighting ....Vision and lighting in the age of melanopsin. This project aims to develop innovative new technologies, which will advance understanding of the effects of light on human behavior mediated via the recently discovered melanopsin photopigment in the eye. The project expects to create a cutting-edge visual display technology, which will deliver the foundation knowledge of melanopsin shapes visual perception. The project will redefine current knowledge of human vision and provide a practical lighting solution to suit the biological needs of humans, especially in relation to the human body’s internal (circadian) clock. Read moreRead less
Decoding neuronal populations for visually-guided decision and action. This project aims to investigate how the cerebral decodes visual information in order to guide sensory-guided actions. Using a high resolution technique, capable of monitoring the activity of many cells in real time, it will study how sensory signals about the motion of visual patterns interact with noise (fluctuations in neuronal activity that are not directly related to the sensation being encoded) in order to determine dec ....Decoding neuronal populations for visually-guided decision and action. This project aims to investigate how the cerebral decodes visual information in order to guide sensory-guided actions. Using a high resolution technique, capable of monitoring the activity of many cells in real time, it will study how sensory signals about the motion of visual patterns interact with noise (fluctuations in neuronal activity that are not directly related to the sensation being encoded) in order to determine decisions made by an animal. Expected outcomes include new knowledge about the cellular circuits responsible for vision, and new technologies for decoding brain activity from physiological measurements, which may in the future guide the development of improved bionic devices such as brain-computer interfaces. Read moreRead less
Stomatopods v Cephalopods: discovery from an information coding arms-race. This proposal aims to unlock the power of a 400 million year old evolutionary arms race between two of earth's most successful predators, cephalopods (e.g. octopus) and mantis shrimp (stomatopods). New knowledge in vision (sensor design), neural coding (circuits and information flow) and behavioural (decisions and actions) innovations from these two groups will have fundamental and applied outcomes. The interdisciplinary ....Stomatopods v Cephalopods: discovery from an information coding arms-race. This proposal aims to unlock the power of a 400 million year old evolutionary arms race between two of earth's most successful predators, cephalopods (e.g. octopus) and mantis shrimp (stomatopods). New knowledge in vision (sensor design), neural coding (circuits and information flow) and behavioural (decisions and actions) innovations from these two groups will have fundamental and applied outcomes. The interdisciplinary and comparative nature of the project aims to amplify outcomes in questions of efficient neural coding, optical design and bio-inspired solutions. Benefits from the study include GPS-free navigation in marine engineering and rapid exposure of research results to millions of people through existing communication programs. Read moreRead less
Microglia and the inflammation spectrum - not just good or bad. Cell-mediated tissue clearance following brain injury is a universal mechanism. However, our understanding of the cells that perform these tasks is very limited. Our project will characterise this inflammatory response at a single-cell level using the zebrafish spinal cord as a versatile experimental model. The project is expected to strongly contribute to the molecular understanding of the mechanisms underlying debris removal and w ....Microglia and the inflammation spectrum - not just good or bad. Cell-mediated tissue clearance following brain injury is a universal mechanism. However, our understanding of the cells that perform these tasks is very limited. Our project will characterise this inflammatory response at a single-cell level using the zebrafish spinal cord as a versatile experimental model. The project is expected to strongly contribute to the molecular understanding of the mechanisms underlying debris removal and will advance innovative technologies that facilitate intellectual progress in neuroscience. It will produce new insights into the process of neuronal degeneration, promote Australia’s growing reputation as a global leader in neuroscience, and provide high quality training for early career researchers.Read moreRead less
Unleashing the potential of VR: reducing sickness in head-mounted displays. Virtual reality (VR) is a breakthrough technology with a host of applied uses. Unfortunately, many people become sick when using head-mounted displays (HMDs). Our project proposes, and aims to test, a new theory of this cybersickness. We intend to quantify the sensory conflicts produced by HMD VR for the first time and measure their effects on perception, eye-movements, balance and well-being. The project will 1) determi ....Unleashing the potential of VR: reducing sickness in head-mounted displays. Virtual reality (VR) is a breakthrough technology with a host of applied uses. Unfortunately, many people become sick when using head-mounted displays (HMDs). Our project proposes, and aims to test, a new theory of this cybersickness. We intend to quantify the sensory conflicts produced by HMD VR for the first time and measure their effects on perception, eye-movements, balance and well-being. The project will 1) determine the causes of, and conditions responsible for, cybersickness; and 2) offer practical information on how to prevent it. These outcomes are expected to directly benefit, and greatly improve HMD use in, fields ranging from defence, education, entertainment, gaming, medicine, real estate, simulation training and tourism.Read moreRead less
Modelling human perceptual-motor interaction for human-machine applications. This project aims to develop a new modelling framework for identifying the perceptual-motor processes that underlie cooperative and competitive human interaction. The project will also determine whether this modelling framework can be combined with modern machine-learning methods to develop artificial agents capable of human level performance. Expected outcomes will include a practical methodology for rapidly generating ....Modelling human perceptual-motor interaction for human-machine applications. This project aims to develop a new modelling framework for identifying the perceptual-motor processes that underlie cooperative and competitive human interaction. The project will also determine whether this modelling framework can be combined with modern machine-learning methods to develop artificial agents capable of human level performance. Expected outcomes will include a practical methodology for rapidly generating models of effective human interaction that can be easily implemented in human-machine systems. This will provide a richer understanding of the fundamental perceptual-motor processes that support robust human interaction and enhanced the effectiveness of human-machine collaboration and training technologies.Read moreRead less
Beyond Neuroinflammation: The Role of Microglia in Synaptic Plasticity. Microglia are the immune cells of the brain and are known to respond to infectious and non-infectious insults to the nervous system. This project aims to use the transparent and genetically amenable brain of the zebrafish, to explore new functions of microglia at the single cell level in the intact, behaving animal, through visualization of cellular components of the brain (neurons, glia, microglia, blood vessels, synapses), ....Beyond Neuroinflammation: The Role of Microglia in Synaptic Plasticity. Microglia are the immune cells of the brain and are known to respond to infectious and non-infectious insults to the nervous system. This project aims to use the transparent and genetically amenable brain of the zebrafish, to explore new functions of microglia at the single cell level in the intact, behaving animal, through visualization of cellular components of the brain (neurons, glia, microglia, blood vessels, synapses), and through the genetic manipulation of synaptic density, and real time observation of microglia in the process.Read moreRead less