The role of the immune system in pain is emerging from recent discoveries, and may hold the key to novel pain treatments. Most people experience brief gut infections from food or contagion without long-term consequences. Many others suffer symptoms for years afterwards - probably the best example of immune-based pain. Our project investigates how immune cells communicate with sensory nerves, and how these communications change from both angles after gut infection or inflammation.
Closing the loop between salience and brain activity. This project aims to understand how animals exposed to an abundance of highly complex information decide what to attend to, that is, how they determine visual saliency. The project will approach this question by systematically tracking visual decision-making in the smallest animal brains, in closed-loop virtual reality environment. This approach will uncover basic working principles applicable to any system that needs to pay attention in a vi ....Closing the loop between salience and brain activity. This project aims to understand how animals exposed to an abundance of highly complex information decide what to attend to, that is, how they determine visual saliency. The project will approach this question by systematically tracking visual decision-making in the smallest animal brains, in closed-loop virtual reality environment. This approach will uncover basic working principles applicable to any system that needs to pay attention in a visually cluttered world, from insects to humans or autonomous vehicles.Read moreRead less
Transient Receptor Potential Channels (TRPs) As Transducers And Targets In Primary Visceral Afferents
Funder
National Health and Medical Research Council
Funding Amount
$669,130.00
Summary
Transient receptor potential, or TRP channels, are involved in generating many of the sensations we perceive, such as heat, cold, touch and pain. Some TRP channels are specialized to signal pain from visceral organs, which we must investigate if we are to find treatments for visceral pain, which are currently lacking.
Creating perceptual experts in Australia's policing and security agencies. This project aims to create the next generation of experts in Australia’s policing and national security agencies, by improving crime scene evidence interpretation. Agencies are under pressure to develop more rigorous training practices that go beyond mere intuition and tradition. This project will use a novel approach that directs learning toward the most diagnostic perceptual cues. Expected outcomes include a solid empi ....Creating perceptual experts in Australia's policing and security agencies. This project aims to create the next generation of experts in Australia’s policing and national security agencies, by improving crime scene evidence interpretation. Agencies are under pressure to develop more rigorous training practices that go beyond mere intuition and tradition. This project will use a novel approach that directs learning toward the most diagnostic perceptual cues. Expected outcomes include a solid empirical basis for national training programs designed to create experts that are accurate, reliable, and continuously improving. Improving the training of experts will ensure the integrity of forensics as evidentiary tools available to police, lead to more reliable courtroom convictions and help safeguard Australia from terrorism and crime.Read moreRead less
Special Research Initiatives - Grant ID: SR0354693
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
Australian e-Research Grid. The e-Research Grid program will research and implement core Grid technologies on APAC and partner's deployed HPC resources, to underpin a broad range of Australian research. The computer science CIs will form collaborative links with international programs, adapting developments to local circumstances. The applications-domain CIs will leverage those into their scientific simulations and databases, using grid integrative techniques and portals. Many CIs participate in ....Australian e-Research Grid. The e-Research Grid program will research and implement core Grid technologies on APAC and partner's deployed HPC resources, to underpin a broad range of Australian research. The computer science CIs will form collaborative links with international programs, adapting developments to local circumstances. The applications-domain CIs will leverage those into their scientific simulations and databases, using grid integrative techniques and portals. Many CIs participate in other RNs linking to their motivating applications, enhancing prospects for research and integration. They participate in the APAC Grid program, leveraging 75 HPC staff nationally. A key aim is interoperability with "real-world Grids": eg e-learning & e-health programs.Read moreRead less
ARC Research Network in Enterprise Information Infrastructure. EII targets consolidated research towards the comprehensive development & establishment of advanced information infrastructures. Its prime purpose is to provide a forum for intellectual exchange by diverse yet complementary research groups, to address the fundamental research problems faced by scientific & business communities when dealing with deployment of information technology to globally distributed, and data intensive environme ....ARC Research Network in Enterprise Information Infrastructure. EII targets consolidated research towards the comprehensive development & establishment of advanced information infrastructures. Its prime purpose is to provide a forum for intellectual exchange by diverse yet complementary research groups, to address the fundamental research problems faced by scientific & business communities when dealing with deployment of information technology to globally distributed, and data intensive environments. EII will address 3 tightly coupled research themes: Ability to interoperate across existing heterogenous platforms & applications; Efficient processing of very large data sets; Technology adoption & impact. Generic results will be applicable to e-science and large business information systems installations.Read moreRead less
Attentional asymmetries for navigation in healthy and clinical groups. This project plans to investigate how differences in attentional capacity between the left and right sides of the brain affect the ability to walk or manoeuvre vehicles between obstacles. To navigate our environment and avoid obstacles, we need to attend to stimuli that are important and ignore those that are not. Unfortunately, the brain’s attentional capacity is limited, which can result in errors and collisions. Using the ....Attentional asymmetries for navigation in healthy and clinical groups. This project plans to investigate how differences in attentional capacity between the left and right sides of the brain affect the ability to walk or manoeuvre vehicles between obstacles. To navigate our environment and avoid obstacles, we need to attend to stimuli that are important and ignore those that are not. Unfortunately, the brain’s attentional capacity is limited, which can result in errors and collisions. Using the techniques of cognitive neuroscience, the project aims to provide a better understanding of the cognitive and neural mechanisms that govern attention in an applied setting. It expects to identify the factors that exacerbate lapses in attention and collisions. The effect of everyday impediments such as mobile phones, alcohol and fatigue will be investigated together with means of minimising these attentional lapses and improving safety.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE150101108
Funder
Australian Research Council
Funding Amount
$352,000.00
Summary
The ups and downs of visuospatial attention. The brain has a remarkable capacity to provide a coherent experience of the world by seamlessly integrating sights and sounds from different locations. It is only after brain damage, or when faced with a high attentional load, that our limitations become apparent. The project aims to investigate these limitations by determining how spatial location influences attention in relation to distractibility, cross-modal input and emotionality. Eye tracking an ....The ups and downs of visuospatial attention. The brain has a remarkable capacity to provide a coherent experience of the world by seamlessly integrating sights and sounds from different locations. It is only after brain damage, or when faced with a high attentional load, that our limitations become apparent. The project aims to investigate these limitations by determining how spatial location influences attention in relation to distractibility, cross-modal input and emotionality. Eye tracking and physiological measures of arousal will be combined with traditional cognitive measures to provide a deeper understanding of spatial attention. This project aims to improve attentional models and develop innovative strategies to increase safety by decreasing inattention and distraction.Read moreRead less
Designing the next generation of geosynthetic liner systems . The project aims to improve the effectiveness of geosynthetic liner systems to contain emerging contaminants such as per-and poly-fluoroalkyl substances (PFASs) for better protection of Australian groundwater resources. The project expects to experimentally validate theory to improve predictive models for performance of geosynthetic liner systems. Expected outcomes include new and updated design guidelines for effective environmental ....Designing the next generation of geosynthetic liner systems . The project aims to improve the effectiveness of geosynthetic liner systems to contain emerging contaminants such as per-and poly-fluoroalkyl substances (PFASs) for better protection of Australian groundwater resources. The project expects to experimentally validate theory to improve predictive models for performance of geosynthetic liner systems. Expected outcomes include new and updated design guidelines for effective environmental protection against PFASs and establishment of new approaches for predicting functional containment lifetimes of liner systems. These outcomes are expected to benefit the waste and remediation industries by influencing next-generation design regulations to ensure long-term environmental protection from PFAS.Read moreRead less
Co-design and dynamic mission optimisation of hypersonic flight vehicles. This project aims to deliver fundamental knowledge by integrating the modelling and control with the design of next generation hypersonic platforms. In an era where Australia's national security reliance on geographic isolation and support from allied forces are being challenged, the research outcomes of this project will play an important role in understanding the capabilities of hypersonic systems. The project will also ....Co-design and dynamic mission optimisation of hypersonic flight vehicles. This project aims to deliver fundamental knowledge by integrating the modelling and control with the design of next generation hypersonic platforms. In an era where Australia's national security reliance on geographic isolation and support from allied forces are being challenged, the research outcomes of this project will play an important role in understanding the capabilities of hypersonic systems. The project will also have significant spillover benefits into other complex system domains, where computational tools can be used to aid in design leading to high embedded-IP products for Australian industry. Furthermore, the proposal encompasses a strong research training aspect, with graduates exposed to leading edge industry and academia.Read moreRead less