Understanding Cortical Circuitry Underlying Sensory Integration And The Consequence Of Its Developmental Disruption
Funder
National Health and Medical Research Council
Funding Amount
$527,395.00
Summary
The mammalian neocortex is organised into six layers with a systematic pattern of wiring that relies on normal development and balanced activity of neurons. This project combines developmental, electrophysiological, optogenetic behavioural, and computational methods to establish how the properties of the precise structure of cortical circuits impact their function and how disruptions in the balanced activity during development affect circuit formation and function in the mature brain.
Delayed Radial Glial Maturation Linked To NFI Deficiency As An Underlying Cause Of Cortical Defects In Humans And Mice
Funder
National Health and Medical Research Council
Funding Amount
$801,979.00
Summary
The timely generation of neurons and glia is important for brain development and consequently brain function throughout life. Nuclear factor I (NFI) genes are important for regulating the production of neurons and glia, and people with disrupted NFI genes have severe cognitive and motor deficits. Using human genetic data and mouse models, we will analyse how disrupting these genes affects brain development, and changes the overall structure and wiring of the cerebral cortex as well as behaviour.
Astroglial Remodelling Of The Interhemispheric Midline Is Regulated By Deleted In Colorectal Cancer (DCC) Signalling And Is Required For Corpus Callosum Formation
Funder
National Health and Medical Research Council
Funding Amount
$669,400.00
Summary
The integration of information between the brain hemispheres occurs via a large bundle of connecting nerve fibres called the corpus callosum. People with a genetic mutation in DCC display mirror movement disorder and some have a severe brain defect where the corpus callosum fails to form, but at present we don’t understand the function of this gene. In this study we will investigate how DCC functions in early brain development to regulate corpus callosum formation and mirror movement disorder.
Discovery Early Career Researcher Award - Grant ID: DE190100136
Funder
Australian Research Council
Funding Amount
$385,288.00
Summary
The influence of naturalistic context on visual short-term memory. This project aims to understand visual short-term memory in natural visual environments using a combination of behavioural and brain data. Visual short-term memory is thought to be critical to complex cognitive tasks such as learning and problem solving, but how low-level image context and high-level semantic information influence short-term memory is poorly understood. This project will use advanced computational image processin ....The influence of naturalistic context on visual short-term memory. This project aims to understand visual short-term memory in natural visual environments using a combination of behavioural and brain data. Visual short-term memory is thought to be critical to complex cognitive tasks such as learning and problem solving, but how low-level image context and high-level semantic information influence short-term memory is poorly understood. This project will use advanced computational image processing tools, neuro-imaging, and psychophysical experiments to provide a comprehensive analysis of short-term memory in naturalistic images. The expected outcome is a better understanding of the neural bottlenecks that limit short-term memory, and a model that predicts memory constraints in natural visual environments.Read moreRead less
The role of the immune system in pain is emerging from recent discoveries, and may hold the key to novel pain treatments. Most people experience brief gut infections from food or contagion without long-term consequences. Many others suffer symptoms for years afterwards - probably the best example of immune-based pain. Our project investigates how immune cells communicate with sensory nerves, and how these communications change from both angles after gut infection or inflammation.
Probing cross modal interactions in the perception of object motion and self-motion. How the brain integrates information from the different senses is not yet understood. This project aims first, to uncover how the brain integrates sound and visual information when perceiving moving objects and second, to probe more complex sensory interactions between sound, vision, and our vestibular senses when perceiving self-motion. This project will expand Australia's knowledge base, strengthen collabora ....Probing cross modal interactions in the perception of object motion and self-motion. How the brain integrates information from the different senses is not yet understood. This project aims first, to uncover how the brain integrates sound and visual information when perceiving moving objects and second, to probe more complex sensory interactions between sound, vision, and our vestibular senses when perceiving self-motion. This project will expand Australia's knowledge base, strengthen collaborative ties between Australia and Japan, and provide unique training opportunities for Australian and Japanese students. Publication of research in top-ranking journals will further promote Australian science abroad. Results will lead to improvements in the design of human-machine interfaces in both industry and entertainment.Read moreRead less
How do bees orchestrate smooth landings? The results should pave the way for the development of novel, biologically inspired strategies for the control of landing in unmanned aerial vehicles. Endowing aircraft with the capability of autonomous flight and landing has been a major challenge in engineering technology. There is now considerable interest, nationally and world wide, in the development of small, intelligent, autonomous airborne vehicles for application in a number of areas of defense, ....How do bees orchestrate smooth landings? The results should pave the way for the development of novel, biologically inspired strategies for the control of landing in unmanned aerial vehicles. Endowing aircraft with the capability of autonomous flight and landing has been a major challenge in engineering technology. There is now considerable interest, nationally and world wide, in the development of small, intelligent, autonomous airborne vehicles for application in a number of areas of defense, surveillance and space exploration. The proposed research will help Australia maintain a leading edge in uncovering important biological principles of flight control that can be translated into useful technological applications.Read moreRead less
Linking human brain structure to function with ultra-high resolution fMRI. This project will examine the structure and function of the sensory cortex of the human brain using ultra-high resolution functional magnetic resonance imaging (7 Tesla MRI). The project pushes new boundaries for resolution with ultra-high field MRI (7 Tesla) and, as such, will advance techniques for the acquisition, analysis, and computational modelling of high-resolution fMRI brain imaging, providing detail of the funct ....Linking human brain structure to function with ultra-high resolution fMRI. This project will examine the structure and function of the sensory cortex of the human brain using ultra-high resolution functional magnetic resonance imaging (7 Tesla MRI). The project pushes new boundaries for resolution with ultra-high field MRI (7 Tesla) and, as such, will advance techniques for the acquisition, analysis, and computational modelling of high-resolution fMRI brain imaging, providing detail of the functional organisation of the sensory cortex at a level never previously possible in the living human brain. This will provide new understanding of the neural-level networks that underpin attention and touch perception in the human brain.Read moreRead less
Transient Receptor Potential Channels (TRPs) As Transducers And Targets In Primary Visceral Afferents
Funder
National Health and Medical Research Council
Funding Amount
$669,130.00
Summary
Transient receptor potential, or TRP channels, are involved in generating many of the sensations we perceive, such as heat, cold, touch and pain. Some TRP channels are specialized to signal pain from visceral organs, which we must investigate if we are to find treatments for visceral pain, which are currently lacking.
Motion and Spatial Coding in Vision. The results of this project will have implications for the design and implementation of artificial visual systems. Completion of this project will depend upon international collaboration - forging links between a young Australian investigator and outstanding overseas scientists as well as providing excellent training opportunities. Subsequent publication of the research in top-ranking international journals will further promote Australian science abroad.