A Multi-national Trial To Predict Treatment Response In Subtypes Of Depression
Funder
National Health and Medical Research Council
Funding Amount
$387,489.00
Summary
Treatment of MDD using trial and error can have serious consequences. It can prolong the patient’s suffering (depression is associated with substantial morbidity, and mortality), prolong their absence from work and other productive activity and increase the burden on their family-carers. This multi-national study will collect genetics, brain function and behavioural data from a large number of participants, allowing for sensitive predictors of response to be determined.
Understanding and manipulating stress physiology of eucalypt seedlings to improve survival and growth. Eucalyptus globulus and E. nitens are the major species being established to meet the 2020 Vision (Anon 1999) of trebling Australia's plantation estate. Seedling mortality and/or reduced growth after planting, linked to the transition from ideal growing conditions in the nursery to stressful conditions (high drought and browsing risk) at the planting sites, significantly increase the costs of ....Understanding and manipulating stress physiology of eucalypt seedlings to improve survival and growth. Eucalyptus globulus and E. nitens are the major species being established to meet the 2020 Vision (Anon 1999) of trebling Australia's plantation estate. Seedling mortality and/or reduced growth after planting, linked to the transition from ideal growing conditions in the nursery to stressful conditions (high drought and browsing risk) at the planting sites, significantly increase the costs of plantation production. By investigating physiological mechanisms of seedlings and their responses to drought and browsing stress during establishment in the field, methods for the production of seedlings acclimated to drought or browsing stress will be developed. The research outcomes will help maximise the financial return on over $28 M per annum being invested by the 8 project partners in seedling production and planting over 80, 000 ha per year for the next 19 years to meet the requirements of Vision 2020.Read moreRead less
Guiding early silvicultural interventions through predicting canopy and crown dynamics in plantations of sub-tropical eucalypts. This project aims to establish the scientific basis for silvicultural treatments of eucalypt plantations for clear wood production. While eucalypt plantations in north-eastern NSW have dramatically increased in recent times, the knowledge base for the production clear, branch-free wood from the tree species used does not exist. A physiological, mechanistic understandin ....Guiding early silvicultural interventions through predicting canopy and crown dynamics in plantations of sub-tropical eucalypts. This project aims to establish the scientific basis for silvicultural treatments of eucalypt plantations for clear wood production. While eucalypt plantations in north-eastern NSW have dramatically increased in recent times, the knowledge base for the production clear, branch-free wood from the tree species used does not exist. A physiological, mechanistic understanding of crown and canopy dynamics as well as branch shedding will form the scientific foundation for stand manipulations such as pruning and thinning to enhance wood quality. Project outcomes will provide the basis for a stand management simulation model for the most important eucalypt species.Read moreRead less
Developing eucalypt plantations for pharmaceutical flavanone production. The project aims to produce the tools and knowledge required to establish plantations of mallee eucalypts for the production of pinocembrin and structurally related flavanones. This is important because these flavanones have been shown to have a range of medicinal applications, including treatment of diseases of the central nervous system. The research plans to focus on producing and establishing trees with improved flavano ....Developing eucalypt plantations for pharmaceutical flavanone production. The project aims to produce the tools and knowledge required to establish plantations of mallee eucalypts for the production of pinocembrin and structurally related flavanones. This is important because these flavanones have been shown to have a range of medicinal applications, including treatment of diseases of the central nervous system. The research plans to focus on producing and establishing trees with improved flavanone content and growth rates, and on understanding the biochemical mechanisms that underlie flavanone production and structural modification. Expected outcomes include supporting the development of profitable plantations in rural Australia and the establishment of plantations more widely in southern Australia, especially on marginal land.Read moreRead less
Adding value to blue mallee plantations. The project aims to develop the tools and knowledge required for establishing and enhancing the profitability of plantations of blue mallee (Eucalyptus polybractea). This is important because mallees have considerable potential for sustainable essential oil and biomass production in low rainfall regions, and they can sequester considerable amounts of carbon in their below-ground parts. The project intends to produce trees with improved oil quality and yie ....Adding value to blue mallee plantations. The project aims to develop the tools and knowledge required for establishing and enhancing the profitability of plantations of blue mallee (Eucalyptus polybractea). This is important because mallees have considerable potential for sustainable essential oil and biomass production in low rainfall regions, and they can sequester considerable amounts of carbon in their below-ground parts. The project intends to produce trees with improved oil quality and yields through chromosome doubling and breeding, and to dissect the mechanisms that underpin essential oil production through the production of mutants and studies of the main monoterpene producing enzyme.Read moreRead less
Nodal Power Saving for Disconnected Ad Hoc Sensor Networks. Bushfire, age care and farming is Australia's today and tomorrow.
A key aspect in bushfire control is early detection of ignitions by spreading miniature low power sensors in a large potential area in an ad hoc fashion and localizing. Response to panic alarm buttons by retirees in a retirement village where they are free to walk around while their location is monitored in real time using a wireless tag they carry to transmit data re ....Nodal Power Saving for Disconnected Ad Hoc Sensor Networks. Bushfire, age care and farming is Australia's today and tomorrow.
A key aspect in bushfire control is early detection of ignitions by spreading miniature low power sensors in a large potential area in an ad hoc fashion and localizing. Response to panic alarm buttons by retirees in a retirement village where they are free to walk around while their location is monitored in real time using a wireless tag they carry to transmit data relating to their physical health(i.e blood pressure, ECG etc). Locating live stocks roaming around in the dairy industry using sensory transmission used for monitoring their statues is vitals for the farmer for improving efficiency.
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Profitable plantations of blue mallee for essential oil production. This project will develop the methods and knowledge required for establishing plantations of eucalypts (blue mallee) with very high and economically viable yields of eucalyptus oil. It is expected that the research will underpin an expansion of the essential oil industry both in Victoria and elsewhere in Australia.
Porous Silica-Based Nanocapsules for Targeted and Controlled Release of Biocides. The project will lead to significant advances in nanotechnology and agrichemical biocide applications. A highly efficient insect control technology will be developed, that will be cost-effective with the ability for targeted control and release of biocides. The encapsulation technology will reduce the total usage and costs of biocides thus benefit the environment in terms of reduced environment pollution and enhanc ....Porous Silica-Based Nanocapsules for Targeted and Controlled Release of Biocides. The project will lead to significant advances in nanotechnology and agrichemical biocide applications. A highly efficient insect control technology will be developed, that will be cost-effective with the ability for targeted control and release of biocides. The encapsulation technology will reduce the total usage and costs of biocides thus benefit the environment in terms of reduced environment pollution and enhanced ecological safety.Read moreRead less
Devising ecologically sustainable restoration programs for degraded rural landscapes by integrating landscape ecology, genetics and ecophysiology. Concern about tree decline in rural landscape is widespread, and disturbingly climate change is predicted to exacerbate this problem. Past ill-considered tree plantings have proven to be economically wasteful, achieved limited ecological resilience and negligible improvement of biodiversity values. Using Tasmania as a 'model system', we will advance t ....Devising ecologically sustainable restoration programs for degraded rural landscapes by integrating landscape ecology, genetics and ecophysiology. Concern about tree decline in rural landscape is widespread, and disturbingly climate change is predicted to exacerbate this problem. Past ill-considered tree plantings have proven to be economically wasteful, achieved limited ecological resilience and negligible improvement of biodiversity values. Using Tasmania as a 'model system', we will advance this problem by undertaking research to determine how seedling establishment, tree growth, carbon storage and water use are influenced by landscape setting, management history, climate change, species type and local varieties. This research will provide a much needed evidence to devise ecologically sustainable tree-plantings in southern Australia.Read moreRead less