Radiotherapy Treatment For Prostate Cancer - A Change In Practice Based On Direct Evidence For Targeting And Toxicity Effects Using Real Outcomes Data
Funder
National Health and Medical Research Council
Funding Amount
$555,129.00
Summary
Radiotherapy for prostate cancer treatment will be more effective when we have better knowledge of what patient anatomy needs to be targeted, and what needs to be avoided. This project will combine data collected during a large Australasian prostate cancer radiotherapy trial, ‘RADAR’, with data collected using new patient imaging methods to determine how patient anatomy impacts on the effectiveness of their treatment and the side-effects they experience.
Prevention Of Multi-drug Resistant Tuberculosis In A High Prevalence Setting: ‘Connecting The DOTS’ In Vietnam
Funder
National Health and Medical Research Council
Funding Amount
$3,382,020.00
Summary
The close contacts of people with multi-drug resistant tuberculosis (MDR-TB) have a high risk of developing the disease. The V-QUIN MDR-TB Trial will evaluate the effectiveness of an oral antibiotic (levofloxacin) in preventing drug resistant TB among infected household contacts of TB patients. Household contacts from 10 Provinces in Vietnam will be randomly allocated to receive six-months of either levofloxacin or a placebo, and then followed for two years to see if they develop tuberculosis.
Protecting Australia And The Region From Emerging And Re-emerging Infectious Diseases.
Funder
National Health and Medical Research Council
Funding Amount
$774,540.00
Summary
The world is facing unprecedented threats from epidemics. In 2014 Ebola showed that issues such as quarantine, personal protective equipment and improved health system capacity are just as critical as drugs and vaccines, yet these are under-researched. Professor MacIntyre is an international expert epidemic control. She will lead a strategic research program to improve control of emerging and re-emerging infections, using her expertise in vaccines, personal protective equipment and biosecurity.
A Randomised Controlled Trial (RCT) Of Azithromycin Versus Doxycycline For The Treatment Of Rectal Chlamydia Infection In Men Who Have Sex With Men.
Funder
National Health and Medical Research Council
Funding Amount
$797,906.00
Summary
Rectal chlamydia is very common among gay men; it can exist for long periods without symptoms leading to ongoing transmission. Azithromycin (1 gram single dose) or 7 days doxycycline (100mg twice daily) are the two recommended treatments globally. But, there is concern about rectal chlamydia treatment with reports of up to 22% failure following azithromycin. We will conduct a randomised trial to compare these treatments for rectal chlamydia and determine which drug works better.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE110100121
Funder
Australian Research Council
Funding Amount
$360,000.00
Summary
Three-dimensional super-resolution nanophotonic fabrication facility. This stimulated emission depletion microscopy nanophotonic fabrication facility will be the first nanophotonic fabrication facility that is able to achieve optical resolution far beyond the diffraction limit, which will facilitate breakthroughs in cutting-edge nanotechnology research areas.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE160100199
Funder
Australian Research Council
Funding Amount
$367,900.00
Summary
Advanced Synthesis System for Two-Dimensional Nanomaterials. Advanced synthesis system for two-dimensional nanomaterials:
This project aims to establish the first synthesis facility in Australia for growing large-area and atomically thin two-dimensional (2-D) nanomaterials including graphene, boron nitride, metal dichalcogenides, metal oxide and nitride nanosheets. Such materials are emerging and innovative materials that possess many properties desirable for energy, electronic, biological, and ....Advanced Synthesis System for Two-Dimensional Nanomaterials. Advanced synthesis system for two-dimensional nanomaterials:
This project aims to establish the first synthesis facility in Australia for growing large-area and atomically thin two-dimensional (2-D) nanomaterials including graphene, boron nitride, metal dichalcogenides, metal oxide and nitride nanosheets. Such materials are emerging and innovative materials that possess many properties desirable for energy, electronic, biological, and environmental related applications. This facility is designed to underpin breakthrough science by providing high-quality large-sized materials to researchers for both fundamental and application research. This new synthesis capability would foster advances in the fundamental understanding of 2-D nanostructures and the development of devices with broad applications in energy conversion and storage, environmental protection, and life sciences.Read moreRead less
A Randomised Open-label Study Comparing The Safety And Efficacy Of Two Alternative Treatment Options In The Management Of HIV-1 Infected Participants Who Have Virologically Failed A Standard First-line Combination ART Regimen
Funder
National Health and Medical Research Council
Funding Amount
$457,676.00
Summary
For the past decade there has been an unprecedented international effort to provide access to care for all HIV-infected people as a basic human right. Most of these people are treated with a simple combination of drugs that are well proven to control HIV. However, what to do when this first drug combination stops working is unknown. This study aims to fill that knowledge gap so that patients failing the first drug combination can be offered a second combination with a maximal chance of success.
Multicentre Trial Of Calcium Channel Blocker Versus Calcium Channel Blocker Plus Cox2 Inhibitor In Preterm Labour
Funder
National Health and Medical Research Council
Funding Amount
$644,130.00
Summary
Preterm birth is a major problem in our society, and has enormous consequences for parents and children. It also has a major impact on scarce financial resources. When women present in preterm labor, current therapies have only limited success in stopping contractions and postponing birth. They have not been shown to reduce the rates of the serious neonatal problems associated with prematurity. This project will be coordinated in Newcastle, N.S.W., and will involve major perinatal centres throug ....Preterm birth is a major problem in our society, and has enormous consequences for parents and children. It also has a major impact on scarce financial resources. When women present in preterm labor, current therapies have only limited success in stopping contractions and postponing birth. They have not been shown to reduce the rates of the serious neonatal problems associated with prematurity. This project will be coordinated in Newcastle, N.S.W., and will involve major perinatal centres throughout Australia, along with overseas centres. It will test a new combination of drugs for their ability to postpone delivery in women presenting with preterm labour. It is postulated that the combination of drugs will be more effective than existing therapies. The drugs used in the trial are Nifedipine and Rofecoxib. Complications of prematurity include neonatal death, cerebral palsy, visual and hearing impairment, and chronic lung disease. These complications are most significant in extremely premature infants - in particular, those under 28 weeks gestation at the time of their delivery. For this reason, the study will focus only on women presenting in labour below 28 weeks. The ability to stop labour is important, but the main aim of any treatment for preterm labour is to reduce the rates of neonatal death and handicap. Babies born to women enrolled in this study will be followed for a period of one year after birth to assess their outcomes. It is our hypothesis that the combination of Rofecoxib and Nifedipine will result in lower rates of death and handicap in babies than Nifedipine alone. In addition, we will examine the rates of side effects in women receiving therapy. Currently used therapies, including intravenous ventolin, have high rates of maternal side effects. Nifedipine and Rofecoxib have both been shown to have low rates of maternal side effects.Read moreRead less
Nonlinear near-field nanophotonics. This project aims to develop nanostructures which employ both high intrinsic nonlinearities and high indices of refraction to create nanophotonic devices. Silicon photonics promises a technological leap forward through efficient photon-photon interactions within lossless dielectric nanoparticles. Light-controlling-light devices open new ways to control light-matter interaction at the nanoscale, which form the basis for many applications from all-optical inform ....Nonlinear near-field nanophotonics. This project aims to develop nanostructures which employ both high intrinsic nonlinearities and high indices of refraction to create nanophotonic devices. Silicon photonics promises a technological leap forward through efficient photon-photon interactions within lossless dielectric nanoparticles. Light-controlling-light devices open new ways to control light-matter interaction at the nanoscale, which form the basis for many applications from all-optical information processing to biomedical sensing. The expected outcomes will provide Australia with advanced technologies of integrated optical circuits with applications in optical communication networks, bioimaging, solar cells and quantum information technologies.Read moreRead less