Improving The Safety Characteristics Of Lentiviral Vectors.
Funder
National Health and Medical Research Council
Funding Amount
$296,250.00
Summary
Gene therapy holds great promise for the treatment of many types of disease including inherited disorders, cancer and cardiovascular disorders. However, the potential of gene therapy has in many cases been limited by the lack of suitable technologies for gene delivery. We have developed a novel gene delivery vehicle from human immunodeficiency virus type 1 (HIV-1). Although this vehicle has many of the characteristics desired of a gene therapy vector its derivation from a retrovirus, particularl ....Gene therapy holds great promise for the treatment of many types of disease including inherited disorders, cancer and cardiovascular disorders. However, the potential of gene therapy has in many cases been limited by the lack of suitable technologies for gene delivery. We have developed a novel gene delivery vehicle from human immunodeficiency virus type 1 (HIV-1). Although this vehicle has many of the characteristics desired of a gene therapy vector its derivation from a retrovirus, particularly one with such an unenviable reputation, raises obvious safety concerns. In order to properly address this issue it is necessary that the vector is carefully designed and properly tested. This project aims to continue our rational, systematic and stepwise approach to the development of our vector with the aim of producing a vector that can be used with a high degree of confidence in its safety, such that it is suitable for clinical usage. Given the highly desirable properties of these vectors, and the wide range of diseases where their use is being considered, the availability of such a vector will have great significance for the widespread practical application of gene therapy. Indeed, several of the projects we are developing with our vector will in all likelihood lead to lead to clinical trials and it is clear that the conduct of these trials will depend on the availability of a suitable vector.Read moreRead less
Improving Quality Of Life In High-risk Cancer Populations: A Randomised Trial Of A Structured Intervention For Head And Neck Cancer Survivors
Funder
National Health and Medical Research Council
Funding Amount
$493,220.00
Summary
Patients treated for head and neck cancer commonly experience pain, disfigurement, eating difficulties, depression and fatigue, undermining confidence and quality of life. This study aims to help patients self-manage their ongoing health problems following completion of treatment. This will be achieved through a randomised trial in which patients will be assisted by a trained oncology nurse to develop a tailored survivorship care plan focusing on the patient’s specific medical and emotional conc ....Patients treated for head and neck cancer commonly experience pain, disfigurement, eating difficulties, depression and fatigue, undermining confidence and quality of life. This study aims to help patients self-manage their ongoing health problems following completion of treatment. This will be achieved through a randomised trial in which patients will be assisted by a trained oncology nurse to develop a tailored survivorship care plan focusing on the patient’s specific medical and emotional concerns.Read moreRead less
A Comprehensive Self-Management Programme For Chronic Obstructive Pulmonary Disease In The Community
Funder
National Health and Medical Research Council
Funding Amount
$391,610.00
Summary
Chronic obstructive pulmonary disease (COPD) is the third leading cause of burden of disease in Australia. It has a major impact on sufferers, their carers and society. This study introduces a new model of community care, based on case management, mentoring to improve self-efficacy and information systems to deliver information and closely monitor disease status. This will improve the quality of life of sufferers, develop healthcare networks and decrease healthcare utilisation.
Integration Of Exercise Counselling And Support Into The Musculoskeletal Help Line For People With Knee Osteoarthritis: A Mixed-methods Evaluation Of A Novel Telephone Service.
Funder
National Health and Medical Research Council
Funding Amount
$437,099.00
Summary
Exercise is an important part of self-management for people with knee osteoarthritis, however access to qualified clinicians is limited for many Australians with knee osteoarthritis. In addition, most exercise providers are not adequately trained to motivate and support people to effectively incorporate exercise into their life on a long-term basis. This project will implement and evaluate a telephone-based exercise counselling and support service for people with knee osteoarthritis.