Preventing Impaired Beta-cell Plasticity, Insulin Secretion And Diabetes After IUGR
Funder
National Health and Medical Research Council
Funding Amount
$760,611.00
Summary
Babies who are born small are at increased risk of later diabetes, partly because restricting growth before birth also impairs development of insulin-secreting cells in the pancreas, impairing later insulin secretion and contributing to diabetes. We will define the mechanisms underlying impaired insulin secretion in a well-established animal model of fetal growth restriction. Importantly, we will also test interventions to improve insulin secretion after intrauterine growth restriction.