Health And Fertility Of Young Men Conceived Using Intra-cytoplasmic Sperm Injection
Funder
National Health and Medical Research Council
Funding Amount
$362,570.00
Summary
The injection of a single sperm into the egg (ICSI) has been the main IVF treatment for men with poor sperm quality since 1993 but is now often used for other types of infertility. Concern has been raised about the health of the children. We will approach >800 parents and their adult sons conceived using ICSI and will assess his general health and development, and fertility. This work will improve patient counselling and practice guidelines, and direct research into the safety of ICSI.
Chromosomes are structures that carry genes in all our cells. Every human cell has 46 chromosomes. In the nucleus of eukaryotic cells, DNA is highly folded and compacted with specific proteins into a dynamic polymer called chromatin. Gene expression, chromosome division, DNA replication, and repair all act, not on DNA alone, but on this chromatin template. The discovery that enzymes can (re)organise chromatin into accessible and inaccessible configurations revealed mechanisms that considerably e ....Chromosomes are structures that carry genes in all our cells. Every human cell has 46 chromosomes. In the nucleus of eukaryotic cells, DNA is highly folded and compacted with specific proteins into a dynamic polymer called chromatin. Gene expression, chromosome division, DNA replication, and repair all act, not on DNA alone, but on this chromatin template. The discovery that enzymes can (re)organise chromatin into accessible and inaccessible configurations revealed mechanisms that considerably extend the information potential of the genetic code. In addition, it is now established that chromatin structural features can influence gene expression. In vitro studies support a model in which chromatin functions as a barrier for the access to DNA. Therefore this organization has to be tighly regulated and dynamic to allow the protein-DNA interactions critical for nuclear functions. Importantly genome organisation provides in addition to genetic information another layer of information, so called epigenetic, which by definition means that it is stably inherited throughout cellular divisions, yet it is not encoded genetically. Thus each cell type will display a specific epigenome. We have recently constructed small human minichromosomes, which are much easier to study than the much larger normal chromosomes. The present project proposes to define the epigenetic feature across an entire human chromosome using our minichhromosomes as working models. The outcome will be a significant gain in our knowledge on the processes underlying epigenetic regulation, the organisation of specialised chromatin domain, and behaviour of the chromosomes.Read moreRead less
Novel Insights Into The Mechanisms Of How Viruses Cause Arthritis-arthralgia
Funder
National Health and Medical Research Council
Funding Amount
$626,459.00
Summary
Many viruses are known to cause arthritis (e.g. HIV, hepatitis viruses, mosquito borne viruses). Symptoms of viral arthritis include joint pain, stiffness, and swelling. The mechanism of disease is poorly understood. We have developed a novel animal model of disease by which to study arthritic disease caused by viral infections. This model provides an excellent opportunity to explore the mechanisms of rheumatic disease in a complete functioning animal and to explore new treatment regimes.
Adolescent Gambling: Prevalence, Risk Factors, and Opportunities for Controls and Interventions. This research will contribute to both scientific knowledge and public policy in an area of considerable public concern. It will measure the prevalence of gambling among adolescents in the ACT, and identify the proportion of youth with actual or potential gambling problems. It will assess their degree of exposure to gambling advertising and their awareness of services for young problem gamblers. The p ....Adolescent Gambling: Prevalence, Risk Factors, and Opportunities for Controls and Interventions. This research will contribute to both scientific knowledge and public policy in an area of considerable public concern. It will measure the prevalence of gambling among adolescents in the ACT, and identify the proportion of youth with actual or potential gambling problems. It will assess their degree of exposure to gambling advertising and their awareness of services for young problem gamblers. The project will also identify risk factors for problem gambling, and protective factors and policy opportunities for the reduction of problem gambling. It will also contribute to methodological knowledge by assessing the validity of multiple measures of problem gambling.Read moreRead less
Longitudinal change for teachers and students in relation to professional learning in statistics education. There is a growing need in Australia's information society for statistically literate citizens, and for more young people to choose to continue their study of statistics past school. The evidence-based research outcomes for both teachers and students in this study, based on an innovative professional learning program catering for individual requirements of teachers, will provide a model fo ....Longitudinal change for teachers and students in relation to professional learning in statistics education. There is a growing need in Australia's information society for statistically literate citizens, and for more young people to choose to continue their study of statistics past school. The evidence-based research outcomes for both teachers and students in this study, based on an innovative professional learning program catering for individual requirements of teachers, will provide a model for industries and education systems to follow in reaching these goals. Further, each of the three collaborating industries will participate in research-based investigations into the benefits of its contributions to enhancing teacher and student outcomes in relation to statistics at the school level.Read moreRead less
Active citizenship of young people through electoral enrolment. Some 300,000 eighteen to twenty-four year old Australians are not enrolled to vote in federal elections, despite compulsory voting. Consequently they do not exercise their rights, and their responsibilities, as citizens in this way. The Australian Ele ctoral C ommission and the researchers will determine why these young Australians are not enrolled and do not vote. We will identify the characteristics of non-participants particularl ....Active citizenship of young people through electoral enrolment. Some 300,000 eighteen to twenty-four year old Australians are not enrolled to vote in federal elections, despite compulsory voting. Consequently they do not exercise their rights, and their responsibilities, as citizens in this way. The Australian Ele ctoral C ommission and the researchers will determine why these young Australians are not enrolled and do not vote. We will identify the characteristics of non-participants particularly those from rural and regional areas. Outcomes include identification of non-enrolled youth and appropriate interventions to engage young Australians to become active, democratic citizens....Read moreRead less
Historical Encyclopedia of Western Australia. To co-ordinate, research, analyse, write and develop an Historical Encyclopedia of Western Australia. The Encyclopedia will be produced as an innovative multimedia CD-ROM and website as well as a printed version.
We have discovered a single tumour factor which causes cancer cachexia, a wasting condition that is one of the worst complications of malignancy, for which there is no current effective treatment. We have developed antibodies which effectively block this condition in preclinical models and have produced human/humanised version of this. This application is to characterise these human antibodies to allow us proceed to clinical trials.
The biology of arbovirus virulence and fitness in arthropod and vertebrate hosts in vivo. In Australia, Ross River virus (RRV) represents significant concern to human health. Between 1992-2005 more than 50,000 notifications of RRV infection have been reported. While not fatal, the disease is responsible for morbidity in the community/individual that can have both social and economic costs. The project has several national benefits. It will help elucidate whether there is any association between ....The biology of arbovirus virulence and fitness in arthropod and vertebrate hosts in vivo. In Australia, Ross River virus (RRV) represents significant concern to human health. Between 1992-2005 more than 50,000 notifications of RRV infection have been reported. While not fatal, the disease is responsible for morbidity in the community/individual that can have both social and economic costs. The project has several national benefits. It will help elucidate whether there is any association between RRV strain and increased risk of RRV transmission and/or occurrence of more severe cases of human disease. It will help develop technologies that can lead towards the identification of viral markers, which could provide new avenues in the design of novel antiviral strategies.
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Mechanisms And Therapies In Cardiovascular Disease
Funder
National Health and Medical Research Council
Funding Amount
$8,360,700.00
Summary
Cardiovascular disease (CVD) claims 1 person every 10 min in Australia and causes 1 in 3 deaths worldwide. The molecular and cellular processes underlying atherosclerosis, vascular injury and thrombosis are highly complex and not well understood. A multifaceted approach is needed to effectively address these key challenges. This Program brings together world experts in these areas to interrogate gaps in our basic understanding of CVD, and to develop novel therapies for CVD patients by exploiting ....Cardiovascular disease (CVD) claims 1 person every 10 min in Australia and causes 1 in 3 deaths worldwide. The molecular and cellular processes underlying atherosclerosis, vascular injury and thrombosis are highly complex and not well understood. A multifaceted approach is needed to effectively address these key challenges. This Program brings together world experts in these areas to interrogate gaps in our basic understanding of CVD, and to develop novel therapies for CVD patients by exploiting new knowledge through integrated research.Read moreRead less