A Study To Investigate Alternative Regimens For Pneumococcal Vaccination Of Infants In A Developing Country
Funder
National Health and Medical Research Council
Funding Amount
$1,622,210.00
Summary
Streptococcus pneumoniae (Pnc) is the leading vaccine preventable cause of serious infection in infants. The current Pnc conjugate vaccine is very expensive (approximately USD $200-infant) so it is unlikely to be affordable for most developing countries. Moreover, as health care access in developing countries may be episodic and unreliable, many children do not receive either complete or timely vaccine courses. Therefore, it is important to investigate affordable and flexible ways to deliver thi ....Streptococcus pneumoniae (Pnc) is the leading vaccine preventable cause of serious infection in infants. The current Pnc conjugate vaccine is very expensive (approximately USD $200-infant) so it is unlikely to be affordable for most developing countries. Moreover, as health care access in developing countries may be episodic and unreliable, many children do not receive either complete or timely vaccine courses. Therefore, it is important to investigate affordable and flexible ways to deliver this vaccine, which are safe and effective. A recent WHO-GAVI meeting to address impediments to the introduction of these vaccines in developing countries recognized the need to evaluate other regimens of Pnc conjugate vaccine as an important research priority. This study has been deliberately formulated with that need in mind. The site for this research is Fiji. Although health services are good, Pnc disease, particularly pneumonia, remains the commonest cause of childhood morbidity and mortality. Fiji has good vaccine coverage and was the first Pacific country to introduce Hib vaccine. The arrival of the new, expensive Pnc conjugate vaccine presents a dilemma for Fiji and many similar countries. The expense of this vaccine would consume a large portion of the health budget. This study has two components: 1. A Phase 2 immunogenicity study (involving 750 infants) to evaluate regimens using reduced numbers of doses of Pnc conjugate vaccine, and using timing of dosing and combinations with the Pnc polysaccharide (PS) vaccine that may be more suited to the epidemiology of Pnc disease in developing countries. 2. An epidemiological study will measure the burden of invasive Pnc disease and pneumonia in Fiji. This will be part of a global effort to address these issues, and will be used to develop rapid assessment tools for these diseases in developing countries. We will seek cofounding for this component.Read moreRead less
Immunising Aboriginal Mothers With Pneumococcal Polysaccharide Vaccine To Prevent Infant Ear Disease And Carriage
Funder
National Health and Medical Research Council
Funding Amount
$1,131,530.00
Summary
Aboriginal children experience the highest rates of acute and chronic ear infections in the world, with resultant permanent ear damage, hearing loss and educational disadvantage. These infections are mainly bacterial, and Streptococcus pneumoniae (pneumococcus) is the predominant pathogen. Pneumococcal colonisation and infection begins within days of birth, many months before any potential immunological protection from infant pneumococcal conjugate vaccine may be expected. New strategies are nee ....Aboriginal children experience the highest rates of acute and chronic ear infections in the world, with resultant permanent ear damage, hearing loss and educational disadvantage. These infections are mainly bacterial, and Streptococcus pneumoniae (pneumococcus) is the predominant pathogen. Pneumococcal colonisation and infection begins within days of birth, many months before any potential immunological protection from infant pneumococcal conjugate vaccine may be expected. New strategies are needed to eliminate, or at least delay, this early-onset pneumococcal colonisation. One such strategy is the administration to the mother of pneumococcal vaccine, which may protect the newborn infant by leading to higher titres of transplacental or breast milk pneumococcal antibodies and-or by reducing carriage (and transmission to the infant) of maternal pneumococci. Previous small studies using this strategy have been encouraging, but there have been no studies properly evaluating carriage or disease endpoints in infants. The polysaccharide pneumococcal vaccine is currently recommended for all Aboriginal and Torres Islander persons aged 15 years or more in the Northern Territory but uptake of the vaccine has been poor. We propose to conduct a pilot study to determine if maternal immunisation with this vaccine, either in the third trimester of pregancy of immediately following delivery, can reduce pneumococcal carriage and the prevalence of middle ear disease among Aboriginal infants at seven months of age. We aim to recruit 210 Aboriginal women who have uncomplicated pregnancies from Darwin and remote communities in the Top End of the Northern Territory. Each subject and their infant offspring will be followed-up after vaccination and at birth, one , two and seven months after birth.Read moreRead less
Movement ecology of granivores: informing fire management of savannas. This project aims to examine the decline in granivorous finches across north Australia and test the hypothesis that an increasingly nomadic lifestyle, associated with tracking grass seed availability over larger spatial scales, is the cause. The project also aims to evaluate how fire affects rangeland functioning, particularly grass diversity, to improve fire management of tropical savannas in northern Australia. This project ....Movement ecology of granivores: informing fire management of savannas. This project aims to examine the decline in granivorous finches across north Australia and test the hypothesis that an increasingly nomadic lifestyle, associated with tracking grass seed availability over larger spatial scales, is the cause. The project also aims to evaluate how fire affects rangeland functioning, particularly grass diversity, to improve fire management of tropical savannas in northern Australia. This project will provide new tools and technologies that will monitor mobile small vertebrates. Expected outcomes will improve the understanding of tropical savanna functioning and fire management. The research aligns with ‘savanna burning’ methodologies and carbon sequestration goals in north Australia.
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Re-integrating Central Australian community cultural collections. This project aims to apply current research on archiving and community access to find practical solutions to managing the large amounts of recorded cultural material of interest to the Central Land Council, the peak Indigenous representative body covering the southern half of the Northern Territory. The project aims to identify and integrate information in a common database, work with community members to create a prioritised list ....Re-integrating Central Australian community cultural collections. This project aims to apply current research on archiving and community access to find practical solutions to managing the large amounts of recorded cultural material of interest to the Central Land Council, the peak Indigenous representative body covering the southern half of the Northern Territory. The project aims to identify and integrate information in a common database, work with community members to create a prioritised list of any at-risk materials and apply locally meaningful categories for managing the archival materials relevant to their community, and deliver appropriate documentation of process, permissions and reports to support ongoing sustainability of the collections.Read moreRead less
Preventing and reversing population declines of northern quolls. This project seeks to develop novel effective strategies to halt and reverse declines in northern quolls by improving their ‘toad-smart’ behaviour. The spread of cane toads threaten northern quolls, which are marsupial predators. We cannot halt the toad invasion, but we can train quolls not to eat cane toads. Trained quolls can survive long term in toad-infested landscapes, and their offspring can learn not to eat toads. This proje ....Preventing and reversing population declines of northern quolls. This project seeks to develop novel effective strategies to halt and reverse declines in northern quolls by improving their ‘toad-smart’ behaviour. The spread of cane toads threaten northern quolls, which are marsupial predators. We cannot halt the toad invasion, but we can train quolls not to eat cane toads. Trained quolls can survive long term in toad-infested landscapes, and their offspring can learn not to eat toads. This project builds on this work by focusing on cultural and genetic transmission of toad-smart behaviour. The project could save numerous quoll populations from extinction.Read moreRead less
Diagnosing river health using invertebrate traits and DNA barcodes. Diagnosing river health using invertebrate traits and DNA barcodes. This project aims to develop indices that link change in invertebrate communities to specific environmental stressors, and combine these indices with innovative, low cost molecular approaches to species identification to rapidly identify the causes of decline. River health assessment methods, usually based on aquatic invertebrates, identify if rivers are impaire ....Diagnosing river health using invertebrate traits and DNA barcodes. Diagnosing river health using invertebrate traits and DNA barcodes. This project aims to develop indices that link change in invertebrate communities to specific environmental stressors, and combine these indices with innovative, low cost molecular approaches to species identification to rapidly identify the causes of decline. River health assessment methods, usually based on aquatic invertebrates, identify if rivers are impaired but must be developed to identify the causes of decline. The intended outcomes are improved sustainable water resource management within and among states, and improved natural resource policy development.Read moreRead less
Modelling and control of mosquito-borne diseases in Darwin using long-term monitoring. Management of mosquito populations is a high public health priority because these insects can spread diseases such as malaria, dengue, Ross River virus, Barmah Forest virus, Murray Valley encephalitis, Japanese encephalitis and Kunjin/West Nile virus. Our research into the effectiveness of mosquito control programs in Darwin is of immediate national relevance and priority given the need to Safeguard Australia ....Modelling and control of mosquito-borne diseases in Darwin using long-term monitoring. Management of mosquito populations is a high public health priority because these insects can spread diseases such as malaria, dengue, Ross River virus, Barmah Forest virus, Murray Valley encephalitis, Japanese encephalitis and Kunjin/West Nile virus. Our research into the effectiveness of mosquito control programs in Darwin is of immediate national relevance and priority given the need to Safeguard Australia from invasive diseases. There is an urgency to undertake our research because global environmental change and increasing movements of people (particularly military personnel) from overseas regions where these diseases are endemic is increasing the vulnerability of northern Australia to the (re)establishment of mosquito borne diseases.Read moreRead less
Modelling the Causes of Regional Disparities across Australia. This project aims to explain the changing patterns of regional economic performance across Australia between 2001-2011 in the context of two developments: major structural shifts in world trade and commodity prices spawning massive mining growth and negative exchange rate impacts elsewhere (for example, manufacturing); and the financial crisis ending the credit boom leaving east coast economies struggling. The resulting regional disp ....Modelling the Causes of Regional Disparities across Australia. This project aims to explain the changing patterns of regional economic performance across Australia between 2001-2011 in the context of two developments: major structural shifts in world trade and commodity prices spawning massive mining growth and negative exchange rate impacts elsewhere (for example, manufacturing); and the financial crisis ending the credit boom leaving east coast economies struggling. The resulting regional disparities have policy implications for education and skills training, housing affordability, infrastructure provision, and community sustainability. These issues will be investigated using a new functional economic regions geography and state of art spatial modelling tools supplemented by regional case studies.Read moreRead less
Fostering Aboriginal sexual well-being by building on strengths. This project aims to use a strengths-based approach to examine how Aboriginal young people draw on social, cultural and personal resources to build their sexual well-being. Many Aboriginal Australians see strengths approaches as essential to addressing disadvantage. However, to date they have not been widely used to address the significant sexual health inequalities experienced by Aboriginal young people. The project will create ne ....Fostering Aboriginal sexual well-being by building on strengths. This project aims to use a strengths-based approach to examine how Aboriginal young people draw on social, cultural and personal resources to build their sexual well-being. Many Aboriginal Australians see strengths approaches as essential to addressing disadvantage. However, to date they have not been widely used to address the significant sexual health inequalities experienced by Aboriginal young people. The project will create new knowledge about ‘what works’ in supporting the sexual well-being of Aboriginal young people, that has relevance to a broad range of disciplines beyond the area of health and well-being.Read moreRead less
Predicting the diagnostic performance of individuals and organisations. Predicting the diagnostic performance of individuals and organisations. This project aims to address diagnostic error in advanced technology systems, by providing a mechanism to assess and improve individual diagnosticians’ performance. Organisations that rely on their employees’ diagnostic skills rarely assess them once the operators become qualified, so there is no basis for interventions that might prevent diagnostic erro ....Predicting the diagnostic performance of individuals and organisations. Predicting the diagnostic performance of individuals and organisations. This project aims to address diagnostic error in advanced technology systems, by providing a mechanism to assess and improve individual diagnosticians’ performance. Organisations that rely on their employees’ diagnostic skills rarely assess them once the operators become qualified, so there is no basis for interventions that might prevent diagnostic errors affecting thousands. This research tests a new method of assessing diagnostic skills based on how skilled operators respond to cues. This project will test how employees’ diagnostic skills change and whether this change corresponds to measures of organisational performance. This research is expected to provide organisations with a tool to pre-empt diagnostic errors that could minimise costs to the economy.Read moreRead less