Mechanisms Responsible For Neurogenic Hypertension: A Novel Interaction Between GABAergic Modulation Of Amygdalo-hypothalamic Pathways And MicroRNA Regulation Of Renin
Funder
National Health and Medical Research Council
Funding Amount
$340,220.00
Summary
A genetic model of hypertension will be used to understand the interrelated role of the brain, nervous system and kidney. The proposed studies will test the hypothesis that disruption of inhibitory neurochemicals in specific regions of the brain, leads to greater nervous system activation of the kidney, which in turn decreases an inhibitory molecule, ultimately resulting in greater activation of a hormonal system responsible for raising blood pressure.
Does Renal Afferent Nerve Activation Contribute To Cardiac Sympathoexcitation And Decreased Renal Function In Heart Failure?
Funder
National Health and Medical Research Council
Funding Amount
$311,860.00
Summary
Removal of the nerves sending information between the kidneys and the brain reduces blood pressure in hypertensive patients. There is intense interest in the use of this procedure in heart failure patients, as it may reduce the harmful high level of nerve activity from the brain to the heart and kidneys. Using an experimental model of heart failure, I will determine whether this approach is beneficial in heart failure and its mechanisms of action.
Neuronal Activity And Functional Magnetic Resonance Imaging (fMRI)
Funder
National Health and Medical Research Council
Funding Amount
$367,561.00
Summary
How does brain activity relate to perception and behaviour? How does functional magnetic resonance imaging (fMRI) of the brain, which measures changes in blood oxygen, relate to the activity of single cells? I will address these questions, comparing electrical measurements of single cells and functional images, and advance our understanding of the brain in health and disease.
Assessing The Impact Of Climate Change On The Transmission Of Mosquito-borne Diseases In Australia
Funder
National Health and Medical Research Council
Funding Amount
$346,689.00
Summary
Global climate change has potentially serious effects on the transmission of mosquito-borne diseases (MBDs). Bayesian spatiotemporal models will be developed to explore the underlying mechanisms of the current distribution of MBDs and to forecast future changes in pattern of these diseases. The model will be useful in examining where and when MBDs are likely to occur and how the future MBDs control strategies and prevention efforts need to be applied and strengthened in Australia.