Quantifying The Effectiveness Of Pertussis Vaccine In Older Adults
Funder
National Health and Medical Research Council
Funding Amount
$448,703.00
Summary
Pertussis is the most poorly controlled vaccine preventable disease in Australia. Childhood pertussis is a well-known public health problem but adult pertussis is also common and has a significant burden on the health system, especially in adults over 65 years. Pertussis vaccines for adults are currently not funded by our national immunisation program. This project will provide vital data to inform whether pertussis vaccination is cost-effective in older Australian adults.
Early Life And Contemporary Influences On Body Composition, Mental Health, And Chronic Disease Risk Markers In The Aboriginal Birth Cohort
Funder
National Health and Medical Research Council
Funding Amount
$3,117,044.00
Summary
The Aboriginal Birth Cohort study has been following the health of Aboriginal babies in the Northern Territory for the last 30 years. The participants were healthy till adolescence, but overweight and risk factors of diseases such as diabetes, kidney and heart disease are emerging. This follow-up will show when and whether these risk factors develop into disease, which factors are protective and which identify early those most at risk of developing diseases that cause the gap in life expectancy.
Pharmaceutical Opioid Prescription For Chronic Pain In Australia: Trajectories Of Prescribing, Risk Of Adverse Events, And Predictors Of Harm
Funder
National Health and Medical Research Council
Funding Amount
$1,086,274.00
Summary
There is concern about rising levels of opioid analgesic prescribing in Australia. This study is important because it will provide evidence about long term outcomes for patients using opioid therapy for chronic non-malignant pain. It will examine prescribing patterns and link them to other health outcomes such as overdose. We will also study patients beginning opioid therapy for chronic pain and follow them up over 2 years to examine outcomes such as pain relief and medication side effects.
Planning, Timing And Quit Success: A Randomised Controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$448,108.00
Summary
The aim of this project is to better understand how quit smoking interventions should be structured to maximise effectiveness; should smokers be encouraged to quit immediately to capitalize on the motivation that caused them to seek help, or first spend time planning, and can the planning be done after quitting? The answers will inform the design and delivery of smoking cessation programs, and potentially programs for other hard-to-change behaviours.
The Evolution Of Childhood Obesity And Its Relationship To Adult Sleep Disordered Breathing
Funder
National Health and Medical Research Council
Funding Amount
$870,842.00
Summary
This project will characterise Obstructive Sleep Apnoea (OSA) in early adulthood. It will assess the prevalence of OSA in a well characterised cohort (the Raine Cohort), representative of the population of young adults in Western Australia. It will define the clinical picture and risk factors associated with abnormal breathing during sleep and will use the extensive longitudinal data collected from 18 weeks gestation until 23 years of age to quantify early life developmental and environmental pr ....This project will characterise Obstructive Sleep Apnoea (OSA) in early adulthood. It will assess the prevalence of OSA in a well characterised cohort (the Raine Cohort), representative of the population of young adults in Western Australia. It will define the clinical picture and risk factors associated with abnormal breathing during sleep and will use the extensive longitudinal data collected from 18 weeks gestation until 23 years of age to quantify early life developmental and environmental predictors that can inform public health policy.Read moreRead less
Increasing Engagement With Online Psychosocial Programs To Improve Mental Health In The Community
Funder
National Health and Medical Research Council
Funding Amount
$352,317.00
Summary
Online therapy programs have a strong evidence base in reducing mental health symptoms. However, take-up of these programs in the community is limited, and low adherence to these programs limits their impact. This project is a randomised controlled trial testing a novel approach to increasing uptake and adherence to psychosocial online programs, involving acceptance facilitation. Results will inform the dissemination of evidence-based psychosocial programs for a range of health conditions.
Novel Serological Tools To Aid Malaria Elimination In The Asia-Pacific
Funder
National Health and Medical Research Council
Funding Amount
$1,362,749.00
Summary
In 2014 Asia-Pacific leaders pledged a malaria free Asia-Pacific by 2030. We will contribute to this goal by developing novel antibody detection tests that can identify people with current and recent past infections. We will then evaluate the utility of these tests both in mass screening and treatment programs and for the rapid delineation of areas where transmission persists from those where it has been eliminated. This will address two major roadblocks to malaria elimination in our region.
Generational And Developmental Pathways Of Childhood And Adolescent Obesity: A Three Generation Cohort Study
Funder
National Health and Medical Research Council
Funding Amount
$1,281,100.00
Summary
There are no community-based follow-up (FU) studies of three generations able to examine the impact of earlier generational factors on the developmental pathways of obesity in third generation. The Mater-University of Queensland Study of Pregnancy (MUSP) cohort now has data covering the grandmothers' (GI) reproductive life course and a FU of their children (GII) into adulthood. We now propose a new study of the "children-of-the-children" who are the grandchildren (GIII) of GI and children of GII
Risks And Benefits Of Breast Cancer Screening: BreastScreen WA Cohort Study Of Overdiagnosis And Breast Cancer Mortality
Funder
National Health and Medical Research Council
Funding Amount
$201,524.00
Summary
Overdiagnosis is the major downside of screening for breast cancer. This occurs when screening detects cancers that would not have caused symptoms in the woman's lifetime. This study aims to quantify the amount of overdiagnosis that occurs in the Australian breast cancer screening program (BreastScreen)
Preconception Determinants Of Child Health And Development: A 4-year Follow Up Of Offspring Born To The Australian Temperament Project
Funder
National Health and Medical Research Council
Funding Amount
$1,065,799.00
Summary
This project will follow offspring born to a large population cohort study that has tracked the mental health and wellbeing of around 2000 participants across 30 years prior to parenthood. The aim is to understand how the lives parents lived before conception, as well as events during pregnancy, shape social and emotional outcomes for their children. Results will inform radically new approaches to promoting child health and development across generations.