Risks And Benefits Of Breast Cancer Screening: BreastScreen WA Cohort Study Of Overdiagnosis And Breast Cancer Mortality
Funder
National Health and Medical Research Council
Funding Amount
$201,524.00
Summary
Overdiagnosis is the major downside of screening for breast cancer. This occurs when screening detects cancers that would not have caused symptoms in the woman's lifetime. This study aims to quantify the amount of overdiagnosis that occurs in the Australian breast cancer screening program (BreastScreen)
Preconception Determinants Of Child Health And Development: A 4-year Follow Up Of Offspring Born To The Australian Temperament Project
Funder
National Health and Medical Research Council
Funding Amount
$1,065,799.00
Summary
This project will follow offspring born to a large population cohort study that has tracked the mental health and wellbeing of around 2000 participants across 30 years prior to parenthood. The aim is to understand how the lives parents lived before conception, as well as events during pregnancy, shape social and emotional outcomes for their children. Results will inform radically new approaches to promoting child health and development across generations.
Understanding The Connections Between Aboriginal And Torres Strait Islander Culture, Health And Wellbeing To Support Action To Improve Outcomes
Funder
National Health and Medical Research Council
Funding Amount
$1,915,802.00
Summary
Little is known about the inter-relationship of cultural factors and Aboriginal and Torres Strait Islander health outcomes and these relationships have not been quantified. Through a large cohort study, this research will produce data that combines standard health measures with newly developed quantitative measures of cultural factors, supported by data linkage infrastructure. Robust analytical methods will be used to inform policy and program development.
Predicting Renal, Ophthalmic, And Heart Events In The Aboriginal Community – THE PROPHECY Study
Funder
National Health and Medical Research Council
Funding Amount
$2,574,486.00
Summary
Up to 30% of adult Aboriginal people have diabetes yet our knowledge of the causes and predictors of complications remain incomplete. We have established the PROPHECY Study to assess the levels of complications in Aboriginal people with diabetes; to understand the way that these complications occur, and identify what clinical, social and genetic factors could predict who will get those complications to guide clinical management and prevention.
Rapidly giving intravenous fluid to prevent or treat shock (fluid resuscitation) is one of the commonest treatments given to critically ill patients. Current guidelines recommend crystalloid solutions but it is unknown whether any particular crystalloid is better than others. This trial will determine whether the use of one of two crystalloid fluids, saline or PlasmaLyte, reduces the risk of organ injuries, such as kidney failure, and improves patients chances of surviving critically illness.
The Australian Peritoneal Dialysis Outcomes And Practice Patterns Study (PDOPPS)
Funder
National Health and Medical Research Council
Funding Amount
$489,749.00
Summary
Peritoneal dialysis (PD) is a form of home dialysis that is both substantially cheaper and associated with better early survival than standard hospital-based haemodialysis. Its use in Australia has been severely limited by poor outcomes compared to the rest of the world. This international study aims to identify “real world” PD centre practices that will lead to better outcomes for Australian patients, greater uptake of home dialysis and health savings of tens of millions of dollars annually.
The Aetiology Of Alcohol Use Disorders In Adulthood: A Generational Perspective
Funder
National Health and Medical Research Council
Funding Amount
$630,927.00
Summary
This study aims to investigate the causes of alcohol problems in adult Australians. We will follow-up participants from a birth cohort study who are now in their thirties. We will assess long term outcomes from in-utero exposure to alcohol and biological, developmental and genetic predictors of alcohol disorders in adulthood. This study also aims to study genetic factors which may be important in the development of alcohol abuse and dependence.
Translation Of Glaucoma Blindness Genes To Improve Clinical Practice
Funder
National Health and Medical Research Council
Funding Amount
$856,795.00
Summary
Glaucoma is a common cause of irreversible blindness. It is currently difficult to predict which patients with the earliest signs of glaucoma will develop blinding stages of the disease. This study will investigate how genes and eye measurements can be used to predict the risk of developing severe glaucoma in people with early signs of disease. This will ensure that high risk individuals can access treatment early, while those at low risk can be spared unnecessary treatment and seen less often.
The Predictors Of Asthma And Lung Function Deficits In The Third Decade: Longitudinal Study Of MACS Sibships
Funder
National Health and Medical Research Council
Funding Amount
$1,176,908.00
Summary
This will be the world’s first birth cohort study to use substantial prospective data to investigate how biological, psychosocial, and environmental markers from birth will predict asthma and lung function in the third decade of life. Our findings will be crucial to the development of new policy and practice for the prevention and management of these conditions and uncover crucial risk factors for young adult asthma.
Enhanced Methods Of Communicating Correct Use Of Child Car Restraints: A Controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$720,599.00
Summary
Working with our associate investigators from the Australian and European child restraint industry, we will conduct a controlled trial of enhanced methods of communicating correct use of child car restraints with product information supplied at the point of sale.