The Australian Parkinson's Project - Uncovering Genetic Risk Factors For Sporadic PD
Funder
National Health and Medical Research Council
Funding Amount
$768,546.00
Summary
Parkinson s disease (PD) is a progressively disabling movement disorder afflicting many elderly Australians. It is caused by the degeneration of specific nerve cells in the brain that produce certain chemicals and patients suffer from an inability to move fluently (or ultimately at all). At present we do not know what triggers this neurodegeneration, but it is believed that complex interactions between inherited (genetic) and environmental factors contribute significantly to the phenomenon. This ....Parkinson s disease (PD) is a progressively disabling movement disorder afflicting many elderly Australians. It is caused by the degeneration of specific nerve cells in the brain that produce certain chemicals and patients suffer from an inability to move fluently (or ultimately at all). At present we do not know what triggers this neurodegeneration, but it is believed that complex interactions between inherited (genetic) and environmental factors contribute significantly to the phenomenon. This project aims to learn more about these complex interactions and their association with PD. People with PD and unaffected individuals will be recruited from throughout Australia and we will look for specific combinations of genetic, environmental and lifestyle factors that either increase or decrease an individual's risk for PD. This research will identify the most common dominant genetic and environmental influences for PD in Australia, enabling scientists to focus on the most relevant biological pathways to target therapeutically.Read moreRead less
Vitamin D And Risk Of Cancer And Mortality In The Melbourne Collaborative Cohort Study
Funder
National Health and Medical Research Council
Funding Amount
$519,829.00
Summary
Overseas studies indicate that vitamin D might protect against certain cancers and other diseases such as heart disease and diabetes. Vitamin D is made when skin is exposed to sunlight. Because sunlight is stronger in Australia than in most of the USA and Europe, where most studies were conducted, the results of those studies might not be relevant to Australia. In this study, we will see if vitamin D is important for cancer and mortality in Australia.
Kidskin: An Intervention To Reduce Sun Exposure In Children
Funder
National Health and Medical Research Council
Funding Amount
$307,775.00
Summary
Melanoma is an important public health problem in Australia. Almost all melanoma is caused by exposure to sunlight, and childhood exposure appears to be particularly important. Thus, if we can reduce childhood exposure, we should ultimately be able to reduce the incidence of melanoma. Despite nation-wide campaigns such as SunSmart, children in Australia still get too much sun exposure. The school offers an ideal opportunity for implementing sun-safety campaigns in children. In 1995, we began the ....Melanoma is an important public health problem in Australia. Almost all melanoma is caused by exposure to sunlight, and childhood exposure appears to be particularly important. Thus, if we can reduce childhood exposure, we should ultimately be able to reduce the incidence of melanoma. Despite nation-wide campaigns such as SunSmart, children in Australia still get too much sun exposure. The school offers an ideal opportunity for implementing sun-safety campaigns in children. In 1995, we began the Kidskin study, which aims to develop, implement and test a school-based program to reduce sun exposure. Preliminary data from the study show that we successfully reduced exposure. However, we are not certain that we have reduced their risk of melanoma. To see if we have reduced the risk of melanoma, we are counting the children's moles. Moles are strongly related to melanoma, and are our best way of measuring actual risk of melanoma. If we are successful, it will be the first time anyone has shown that reducing exposure to sunlight during childhood will lead to a reduction in the incidence of melanoma in later life.Read moreRead less
Helping Women Meet Their Activity Goals: Randomised Trial Of A Personalised Program Delivered By Mobile Telephone
Funder
National Health and Medical Research Council
Funding Amount
$493,346.00
Summary
Cardiovascular disease is the leading cause of death in Australian women, but is less likely among women who are active. Because women are less active than men, and women with young children are the least active of all, we developed a program to increase postnatal women's physical activity. Women in the pilot study reported high program satisfaction and more physical activity, because the program focused on them (not their kids) and helped them prioritise time for physical activity.
DNA methylation is a process that plays a critical role throughout life by altering the expression of genes. We aim to investigate the potential use of methylation as a target for prevention strategies and for men with no clinical evidence of disease, as a marker of their risk for prostate cancer, particularly its aggressive form.
The Role Of Allostatic Load As A Mediator Between Chronic Stress And Poor Health For Dementia Caregivers
Funder
National Health and Medical Research Council
Funding Amount
$237,321.00
Summary
The potential risk to caregivers of dementia patients of poor health outcomes is well documented. The burden imposed by caregiving is most often described in terms of chronic stress. While it is apparent that some stress-relieving social interventions (e.g. respite) may have short-term benefits, it is also clear that many caregivers are unable or unwilling to avail themselves of such programs. The way in which chronic stress leads to poor health is not well understood. Our study of spouse caregi ....The potential risk to caregivers of dementia patients of poor health outcomes is well documented. The burden imposed by caregiving is most often described in terms of chronic stress. While it is apparent that some stress-relieving social interventions (e.g. respite) may have short-term benefits, it is also clear that many caregivers are unable or unwilling to avail themselves of such programs. The way in which chronic stress leads to poor health is not well understood. Our study of spouse caregivers seeks to identify the groups of physiological systems that suffer cumulative wear and tear as a result of chronic stress. This wear and tear is called allostatic load, and is thought to lead to poor health. It is expected that caregivers in our study will have greater allostatic load than people who are not caregivers. Should this be the case, our results will provide the basis for the design of tailored interventions to maintain caregivers in good health. The potential of such preventive health measures is to reduce caregivers' health care costs and reliance on community support, and to help caregivers to continue providing care for their spouses at home.Read moreRead less
A Controlled Longitudinal Study Of Knee Cartilage Volume If The Offspring Of Subjects With Osteoarthritis Of The Knee.
Funder
National Health and Medical Research Council
Funding Amount
$144,392.00
Summary
Osteoarthritis is the most common cause of musculoskeletal disability and cost in Australia. Both genetic and environmental factors have been implicated as causes of this disease. As yet, however, there are no proven strategies for prevention of this very common condition and treatment of established disease is unsatisfactory. Part of the reason for this is the fact that there is no sensitive and accurate measure of early disease. In this study, we plan to evaluate knee cartilage volume assessed ....Osteoarthritis is the most common cause of musculoskeletal disability and cost in Australia. Both genetic and environmental factors have been implicated as causes of this disease. As yet, however, there are no proven strategies for prevention of this very common condition and treatment of established disease is unsatisfactory. Part of the reason for this is the fact that there is no sensitive and accurate measure of early disease. In this study, we plan to evaluate knee cartilage volume assessed by magnetic resonance imaging. This is a promising new candidate which is both accurate and sensitive. We will be measuring knee volume both cross-sectionally and longitudinally in the offspring of patients who have had knee replacement for osteoarthritis and comparing them to randomly selected controls to see if knee volume can be utilised as a marker of early or asymptomatic disease particularly in identifying which treatments may be effective at preventing osteoarthritis in later life.Read moreRead less