Enhanced sensitivity of electrospray ionization mass spectrometry. Enhanced sensitivity of electrospray ionization mass spectrometry. This project aims to enhance the sensitivity of nano-electrospray ionization mass spectrometry (nanoESI-MS) by an order of magnitude by simultaneously overcoming the two interdependent limitations in ion generation and transmission efficiency. This project will design glass capillaries and tubes with complex structures to enable both multiplexing ion generation fr ....Enhanced sensitivity of electrospray ionization mass spectrometry. Enhanced sensitivity of electrospray ionization mass spectrometry. This project aims to enhance the sensitivity of nano-electrospray ionization mass spectrometry (nanoESI-MS) by an order of magnitude by simultaneously overcoming the two interdependent limitations in ion generation and transmission efficiency. This project will design glass capillaries and tubes with complex structures to enable both multiplexing ion generation from a single capillary and geometrically matching the bore of the tube collecting the emitted ion plume. NanoESI-MS has become an indispensable analytical tool for proteomics and synthetic chemistry. The significant enhancement of nanoESI-MS sensitivity in this project is expected to accelerate progress in disease research, biomarker discovery and drug development.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE150100001
Funder
Australian Research Council
Funding Amount
$410,000.00
Summary
Collaborative advanced spectroscopy facility for materials and devices. Collaborative advanced spectroscopy facility for materials and devices: This project aims to enable advancements in electronics, photonics, biomedicine, and sensing through a collaborative, open access facility for advanced optical and chemical spectroscopy of thin films, materials, and devices. The intended capabilities include high-speed, precise and state-of-the-art spectroscopy tools which enable in situ characterisation ....Collaborative advanced spectroscopy facility for materials and devices. Collaborative advanced spectroscopy facility for materials and devices: This project aims to enable advancements in electronics, photonics, biomedicine, and sensing through a collaborative, open access facility for advanced optical and chemical spectroscopy of thin films, materials, and devices. The intended capabilities include high-speed, precise and state-of-the-art spectroscopy tools which enable in situ characterisation at sub-micron scales and cryogenic temperatures, under bio-simulated environments, down to single pixel resolution, with parallel imaging and spectroscopy, and of fluids and biomaterials. The instrumentation will include cryogenic sub-micron photoluminescence and micro-Raman spectroscopy, single pixel optical and dark field spectroscopy, continuous wave terahertz time-domain spectroscopy, wide wavelength microscopic spectroscopy, and temperature-jump kinetics spectroscopy. It is expected that these complementary instruments will accelerate research in materials and devices for plasmonics, nanoelectronics, biomedicine, biochemistry, security, and forensic science.Read moreRead less
Terahertz Metamaterials for Molecular Sensing. Metamaterials are fascinating new man-made structures that can manipulate beams of light in surprising ways; eg. metamaterials are being studied as 'cloaking devices' to render objects invisible. Our proposal aims for fundamental studies and improvement of metamaterials operating in the terahertz (T-ray) frequency regime. The outcome will be the exploitation of new metamaterial devices for high performance molecular sensors and electromagnetic filte ....Terahertz Metamaterials for Molecular Sensing. Metamaterials are fascinating new man-made structures that can manipulate beams of light in surprising ways; eg. metamaterials are being studied as 'cloaking devices' to render objects invisible. Our proposal aims for fundamental studies and improvement of metamaterials operating in the terahertz (T-ray) frequency regime. The outcome will be the exploitation of new metamaterial devices for high performance molecular sensors and electromagnetic filters operating at terahertz frequencies. Socioeconomic benefits to Australia include: (i) increased knowledge-base in metamaterials operating in the terahertz range; (ii) the underpinning of applications in biophotonics and communications; and (iii) commercialisation of novel terahertz devices.Read moreRead less