A Micro-Physiological System to Mimic Human Microbiome-Organ Interactions. This project aims to mimic gut microbiome-organ interactions by developing a microbial-gut coculture chip, which can reversibly interface with other organs-on-chips. This is achieved through the systematic integration of highly customisable biofabrication and microfluidic technologies. This project fills a critical technological gap in the availability of an animal-alternative system to investigate microbiome-host interac ....A Micro-Physiological System to Mimic Human Microbiome-Organ Interactions. This project aims to mimic gut microbiome-organ interactions by developing a microbial-gut coculture chip, which can reversibly interface with other organs-on-chips. This is achieved through the systematic integration of highly customisable biofabrication and microfluidic technologies. This project fills a critical technological gap in the availability of an animal-alternative system to investigate microbiome-host interactions, which will greatly complement existing meta-omics approaches. The deliverables include a proof-of-concept system validated for gut-liver axis as well as the creation of new knowledge and framework to assimilate design thinking and advanced manufacturing to elevate tissue engineering into physiology engineering. Read moreRead less
Breakthrough technologies in implantable bionics. This project aims to introduce revolutionary changes in implantable bionics via miniaturisation, automation and improved reliability and generating new knowledge by leveraging recent advances in laser processes. Expected outcomes include innovative hybrid thin-film/thick-film electrode arrays with more channels and charge-carrying capacity for neuromodulation; novel glass interfaces that facilitate deeply-miniaturised hermetic packages; and failu ....Breakthrough technologies in implantable bionics. This project aims to introduce revolutionary changes in implantable bionics via miniaturisation, automation and improved reliability and generating new knowledge by leveraging recent advances in laser processes. Expected outcomes include innovative hybrid thin-film/thick-film electrode arrays with more channels and charge-carrying capacity for neuromodulation; novel glass interfaces that facilitate deeply-miniaturised hermetic packages; and failure analysis to ensure study aims result in new processes that are as or more reliable than the current state-of-the-art. This work will create new and novel manufacturing processes, and trains the next generation of innovators equipped with the tools to advance implantable bionics into the future.Read moreRead less
Stereolithographic Additive Manufacturing of Semicrystalline Thermoplastics. This project aims to advance the development of high-throughput stereolithographic additive manufacturing of thermoplastic polymers and composites by employing a multi-colour irradiation schemes in conjunction with photopolymerisable, ring-opening monomer resin formulations. The fundamental scientific understanding, engineering expertise, and concomitant technology advances generated by this project are anticipated to e ....Stereolithographic Additive Manufacturing of Semicrystalline Thermoplastics. This project aims to advance the development of high-throughput stereolithographic additive manufacturing of thermoplastic polymers and composites by employing a multi-colour irradiation schemes in conjunction with photopolymerisable, ring-opening monomer resin formulations. The fundamental scientific understanding, engineering expertise, and concomitant technology advances generated by this project are anticipated to enable additive manufacturing to transition from the rapid prototyping of individual, unique items to the high volume production of robust, reprocessable plastic parts. By obviating the large capital expense of conventional fabrication, this developed technology should provide a path to reinvigorate Australian manufacturing.Read moreRead less
Characterization, modelling and control for robotic thermal ablation. This project aims to study the fundamental issues in robotic-assisted minimally invasive thermal ablation, an important therapy for patients with cancer. It aims to establish advanced characterisation and modelling methodologies for thermomechanical behaviours of soft tissues, together with automatic planning and precise manipulation control techniques for robotic thermal ablation therapies. The project will establish new know ....Characterization, modelling and control for robotic thermal ablation. This project aims to study the fundamental issues in robotic-assisted minimally invasive thermal ablation, an important therapy for patients with cancer. It aims to establish advanced characterisation and modelling methodologies for thermomechanical behaviours of soft tissues, together with automatic planning and precise manipulation control techniques for robotic thermal ablation therapies. The project will establish new knowledge and instrumentation for robotic-assisted thermal ablation and minimally invasive surgery. The outcomes of this project will produce important benefits to medicine, healthcare and medical technology industry, and further consolidate Australia’s position in innovative technologies and research and development of advanced healthcare systems and instruments.Read moreRead less
Cleaning of tough paints on advanced composites using laser technologies. This project researches fundamental knowledge and algorithms to underpin the deployment of a novel ablation technology using pulsed lasers to remove paints, in particular tough paints, from surfaces of advanced composite structures, e.g. airframes and turbine blades. It establishes thermal mechanical models to describe ablation mechanisms of pulsed laser removal of the paint using both IR and UV bands. Optimal processing p ....Cleaning of tough paints on advanced composites using laser technologies. This project researches fundamental knowledge and algorithms to underpin the deployment of a novel ablation technology using pulsed lasers to remove paints, in particular tough paints, from surfaces of advanced composite structures, e.g. airframes and turbine blades. It establishes thermal mechanical models to describe ablation mechanisms of pulsed laser removal of the paint using both IR and UV bands. Optimal processing protocols to clean paints with different properties, without damaging the underlying composites, will be determined and demonstrated. It meets a cleaning technology need for this paint-on-composites material system to support retrofitting and re-manufacturing in industry. These are crucial industry requirements. Read moreRead less