Integrated Multidimensional Gas Chromatography - Spectroscopic Detection Methodology for Chemical Marker Discovery. Chemical species are pervasive in our modern society and are found in personal care products, foods, additives, petroleum products, illicit drugs, pharmaceuticals and pollutants. Each sample must be analysed to determine its accurate composition, and as a safeguard. This requires chemical methods of analysis. Classical chemical methods may fail when samples become too complex, or t ....Integrated Multidimensional Gas Chromatography - Spectroscopic Detection Methodology for Chemical Marker Discovery. Chemical species are pervasive in our modern society and are found in personal care products, foods, additives, petroleum products, illicit drugs, pharmaceuticals and pollutants. Each sample must be analysed to determine its accurate composition, and as a safeguard. This requires chemical methods of analysis. Classical chemical methods may fail when samples become too complex, or they may lead to imprecise identification. This Frontier Technologies proposal has broad national and international relevance through development of new methods for authentication of chemical identity and the subsequent superior ability to characterise numerous sample compositions.Read moreRead less
Microfluidic Separation Science: Innovative Technology for Characterising Complex Chemical Systems. At present there is a need for fast and detailed chemical analysis of complex samples, such as those important to biomedical diagnostics and forensic science. Innovative technology will be developed here in order to reduce analysis time whilst maintaining the integrity of the chemical information contained within the sample. This step change in separation science will directly aid biomedical diagn ....Microfluidic Separation Science: Innovative Technology for Characterising Complex Chemical Systems. At present there is a need for fast and detailed chemical analysis of complex samples, such as those important to biomedical diagnostics and forensic science. Innovative technology will be developed here in order to reduce analysis time whilst maintaining the integrity of the chemical information contained within the sample. This step change in separation science will directly aid biomedical diagnostics, forensic sample determination and industrial process monitoring through decreased analysis time with an increase in the chemical information gained. By performing chemical separations on a microfluidic scale a reduction in both the cost of analysis and impact of solvent waste on the environment will be achieved.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC140100022
Funder
Australian Research Council
Funding Amount
$2,148,935.00
Summary
ARC Training Centre for Portable Analytical Separation Technologies. ARC Training Centre for Portable Analytical Separation Technologies. Portable analytical separation systems will enable point-of sample analysis for complex samples in food, environmental and clinical applications. The Training Centre aims to train the next generation of industry-ready Australian researchers through creating a sustainable research partnership between university-based researchers and Australian industry focused ....ARC Training Centre for Portable Analytical Separation Technologies. ARC Training Centre for Portable Analytical Separation Technologies. Portable analytical separation systems will enable point-of sample analysis for complex samples in food, environmental and clinical applications. The Training Centre aims to train the next generation of industry-ready Australian researchers through creating a sustainable research partnership between university-based researchers and Australian industry focused on developing new capabilities and technologies that have the potential to facilitate, support, or catalyse the progressive deployment of portable separation science technologies into society. This will enable the development of new, portable and affordable analytical separation systems and contribute to creating a sustainable, globally competitive manufacturing industry in Australia.Read moreRead less
Development of novel passive sampling devices for ammonia monitoring. This project will develop novel inexpensive passive samplers for ammonia which is an indicator for faecal contamination in stormwater. These devices will increase dramatically the efficiency in isolating intermittent faecal contamination sources in drainage networks by eliminating the need for extensive manual sampling and inspection operations.
New hyphenated chromatographic and spectroscopic methods for oil analysis. This project aims to use novel chemical separation methods combined with spectroscopy to identify useful markers in olive oil and essential oil to ensure purity, quality and authenticity, which are all ongoing issues in these industries in Australia and overseas. The project plans to compare and integrate results of multidimensional gas chromatography combined with mass spectrometry and Fourier transform infrared analyses ....New hyphenated chromatographic and spectroscopic methods for oil analysis. This project aims to use novel chemical separation methods combined with spectroscopy to identify useful markers in olive oil and essential oil to ensure purity, quality and authenticity, which are all ongoing issues in these industries in Australia and overseas. The project plans to compare and integrate results of multidimensional gas chromatography combined with mass spectrometry and Fourier transform infrared analyses with data libraries to generate precise molecular identification. The outcome is expected to help monitor adulteration of oils and maintain the high quality standards of Australian produce.Read moreRead less
Advanced Separation Technologies and Chemometric Data Processing for Macromolecular Materials and Metabolite Profiling. The project will develop innovative separation technologies for specialised materials, which could lead the scientific export industry in Australia, with employment benefits to the community. Partner, Dow has links with researchers around the world, and this project will allow Australian researchers to access the network of Dow laboratories and projects and develop a long-term ....Advanced Separation Technologies and Chemometric Data Processing for Macromolecular Materials and Metabolite Profiling. The project will develop innovative separation technologies for specialised materials, which could lead the scientific export industry in Australia, with employment benefits to the community. Partner, Dow has links with researchers around the world, and this project will allow Australian researchers to access the network of Dow laboratories and projects and develop a long-term relationship. The analysis methods to be developed will focus on metabolite profiling which has relevance to a broad range of biological monitoring activities from human health, to plant genetics and breeding. New generation polymer materials will be characterised by using the new techniques developed. The methods will be platform technologies for future studies eg. anti-terrorism bio- and chemo-monitoring.Read moreRead less
Simulation, Modelling, Prediction and Two-Dimensional Retention Database Development in Comprehensive Two-Dimensional Gas Chromatography (GC×GC). Quality of life is enhanced by the application of chromatography to many aspects of living. It is an existing technology made more powerful when used as comprehensive two-dimensional gas chromatography (GC×GC), an advanced form of GC. This project will apply new interpretation strategies to GC×GC to improve precise chemical analysis in many areas inclu ....Simulation, Modelling, Prediction and Two-Dimensional Retention Database Development in Comprehensive Two-Dimensional Gas Chromatography (GC×GC). Quality of life is enhanced by the application of chromatography to many aspects of living. It is an existing technology made more powerful when used as comprehensive two-dimensional gas chromatography (GC×GC), an advanced form of GC. This project will apply new interpretation strategies to GC×GC to improve precise chemical analysis in many areas including: measurement of 'good fats' in foods, sources of illicit drugs, allergens in perfumes, disease profiling through metabolite monitoring and the detection of performance enhancing drugs in sport. Based on this research, the science of chromatography will be advanced in Australia and throughout the world, using Australian technology and expertise.Read moreRead less
Marine oil seeps and airborne particulates characterisation for organic compositional fingerprinting by using novel gas chromatographic technologies. Comprehensive two-dimensional gas chromatography (GCxGC) is a powerful new tool for studying complex organic materials. The technique provides a highly sensitive method of fingerprinting not only the composition of the material but also its environmental history and behaviour. In this project the technique will be applied to a range of petroleum- ....Marine oil seeps and airborne particulates characterisation for organic compositional fingerprinting by using novel gas chromatographic technologies. Comprehensive two-dimensional gas chromatography (GCxGC) is a powerful new tool for studying complex organic materials. The technique provides a highly sensitive method of fingerprinting not only the composition of the material but also its environmental history and behaviour. In this project the technique will be applied to a range of petroleum-related organic samples, including oil seeps from the ocean floor, and airborne particulates contributing to air pollution. The research will lead to a better understanding of geochemistry of petroleum-related materials and their potential impact on the environment and on public health.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0237784
Funder
Australian Research Council
Funding Amount
$707,000.00
Summary
Hyphenated Separations/Mass Spectrometry Technology for Protein and Natural Product Characterisation. This proposal consolidates the 3 institutions' collaboration on the ACROSS (Australian Centre for Research on Separation Science) initiative, providing fundamental technology for chemical structural analysis of complex samples involving high resolution protein and natural product characterisation. Requested equipment supports complete characterisation of important novel target molecules. GCxGC-T ....Hyphenated Separations/Mass Spectrometry Technology for Protein and Natural Product Characterisation. This proposal consolidates the 3 institutions' collaboration on the ACROSS (Australian Centre for Research on Separation Science) initiative, providing fundamental technology for chemical structural analysis of complex samples involving high resolution protein and natural product characterisation. Requested equipment supports complete characterisation of important novel target molecules. GCxGC-TOFMS technology will validate our newly patented multidimensional separation techniques. Q-TOF-TOFMS technology, novel patented protein prefractionation approaches, and sample handling with high resolution characterisation / identification of new target proteins allows advanced proteomics developments. Proteomics depends critically upon sophisticated MS techniques. These technologies will: ·enhance the capabilities and expertise in these sciences in the SE Australian area; ·ensure the ACROSS initiative achieves internationally competitive research capabilities; ·provide commercial endpoints in fields associated with analysis of proteins, essential oils and other natural (bio)substances.Read moreRead less
New Enantiomeric Separation Technologies for Natural Product, Pharmaceuticals and Environmental Pollutant Characterisation. Enantiomeric characterisation allows evaluation of drug purity for potentially harmful constituents, consumer protection against adulteration of essential oils and natural materials, and study of chemical interactions in biochemical/environmental systems. Chromatograph technologies (GC, HPLC and CE)for enantioseparation are available, however limitations prevent multicompon ....New Enantiomeric Separation Technologies for Natural Product, Pharmaceuticals and Environmental Pollutant Characterisation. Enantiomeric characterisation allows evaluation of drug purity for potentially harmful constituents, consumer protection against adulteration of essential oils and natural materials, and study of chemical interactions in biochemical/environmental systems. Chromatograph technologies (GC, HPLC and CE)for enantioseparation are available, however limitations prevent multicomponent characterisation of complete sample mixtures. Critical choices involve: choosing a chiral selector that interacts differentially upon all enantiomers; incorporation of selector into high-efficiency chromatographic systems; application to all target compounds in the sample. We will synthesise novel chiral selectors, incorporate these into new separation columns, apply ultra-high resolution 2-dimensional GCxGC to broad-spectrum chiral analysis of volatile chemical samples.Read moreRead less