A gold-coated magnetic nanoparticle biosensor for detecting microRNA. The project aims to develop a biosensor for detecting short sequences of RNA, called microRNA (miRNA) in blood. There are about 100 miRNA sequences that are involved in most biological processes. Changes in the levels of some miRNA sequences can serve as a biomarker for many diseases including cancers. The miRNA will be detected using gold-coated magnetic nanoparticles modified with DNA sequences complementary to the miRNA of ....A gold-coated magnetic nanoparticle biosensor for detecting microRNA. The project aims to develop a biosensor for detecting short sequences of RNA, called microRNA (miRNA) in blood. There are about 100 miRNA sequences that are involved in most biological processes. Changes in the levels of some miRNA sequences can serve as a biomarker for many diseases including cancers. The miRNA will be detected using gold-coated magnetic nanoparticles modified with DNA sequences complementary to the miRNA of interest to capture the miRNA. Application of a magnetic field allows the levels of miRNA to be detected electrochemically. The expected outcome is a commercialisable biosensor for miRNA both as a diagnostic early detection device and a prognostic device for a range of miRNA biomarkers.Read moreRead less
Untangling Complex Molecular Spectra with an Optical Frequency Comb. The exhaled breath is a rich source of information about the inner life of the human body - but untangling this complicated molecular mixture into a quantitative measurement of its constituent components is currently an unsolved problem. This project aims to develop a new instrument that leverages the Nobel Prize winning technology of the optical frequency comb to enable analysis of such mixtures. It is expected that by combini ....Untangling Complex Molecular Spectra with an Optical Frequency Comb. The exhaled breath is a rich source of information about the inner life of the human body - but untangling this complicated molecular mixture into a quantitative measurement of its constituent components is currently an unsolved problem. This project aims to develop a new instrument that leverages the Nobel Prize winning technology of the optical frequency comb to enable analysis of such mixtures. It is expected that by combining a frequency comb source, with an innovative detector and a highly sensitive sampling system, a real-time spectral signature of each sample will be generated. Computational techniques developed by the radio astronomy community will then be used to extract concentrations of individual molecular components at the parts-per-billion level.Read moreRead less
Hierarchically porous polymer monoliths for separation science. Understanding the molecular composition of biomarkers involved in cell-cell communication and the fate of nanoparticles in the environment is critical to improve our understanding of diseases and environmental processes. This project will develop a new approach for the design of separation media that will greatly improve the efficiency of techniques used to analyse these complex samples. The separation media will consist of a polyme ....Hierarchically porous polymer monoliths for separation science. Understanding the molecular composition of biomarkers involved in cell-cell communication and the fate of nanoparticles in the environment is critical to improve our understanding of diseases and environmental processes. This project will develop a new approach for the design of separation media that will greatly improve the efficiency of techniques used to analyse these complex samples. The separation media will consist of a polymer containing large flow-through pores as well as well-defined mesopores. This dual porous skeleton will allow for the size-based separation of biomarkers and nanoparticles. The new separation media will enable the development of new technologies with applications in areas such medicine and environmental science.Read moreRead less
Coherent LIDAR for Monitoring Air Pollution and Atmospheric Wind-fields. Industry, government and civil defence urgently require compact, field deployable sensors that can measure winds and monitor pollution in the atmospheric boundary layer. Without these sensors they are unable to measure and make informed decisions about windborne dispersion of industrial emissions, environmental pollutants, and chemical/biological toxins under operational conditions. The project will develop eye-safe cohere ....Coherent LIDAR for Monitoring Air Pollution and Atmospheric Wind-fields. Industry, government and civil defence urgently require compact, field deployable sensors that can measure winds and monitor pollution in the atmospheric boundary layer. Without these sensors they are unable to measure and make informed decisions about windborne dispersion of industrial emissions, environmental pollutants, and chemical/biological toxins under operational conditions. The project will develop eye-safe coherent lidar (light detection and ranging) systems that can measure wind velocities at ranges of up to 10 km with an accuracy of about 1 m/s, and can be deployed to field sites as required. The technology will be of major interest to the commercial sector.Read moreRead less
Nanolayer Degradation Deposits on Cold Rolled Steel Strip: The Influence of Rolling Oil Emulsions in Sequential Oxidative and Reductive Environments. Cold rolled steel strip, produced by BHP Steel, is a precursor material for production of internationally recognised Australian products ZINCALUMER Steel and COLORBONDR Steel. Lubricating oils supplied by Quaker Chemical are used during the cold rolling process. When exposed to the direct fired annealing process, nanolayer surface residues can de ....Nanolayer Degradation Deposits on Cold Rolled Steel Strip: The Influence of Rolling Oil Emulsions in Sequential Oxidative and Reductive Environments. Cold rolled steel strip, produced by BHP Steel, is a precursor material for production of internationally recognised Australian products ZINCALUMER Steel and COLORBONDR Steel. Lubricating oils supplied by Quaker Chemical are used during the cold rolling process. When exposed to the direct fired annealing process, nanolayer surface residues can develop from rolling oil films and adversely affect subsequent steel surface wetting by the molten zinc alloy. This collaborative research project will investigate the fundamental nature of nanolayer residue formation, using advanced thermal and surface analysis techniques, with the aim of determining the factors influencing residue formation and reducing their impact.Read moreRead less
Compact and versatile chip lasers for three-dimensional mine surveying. This project will bring together a world leading mine survey company, The University of Adelaide and Macquarie University researchers, to develop an 'eye-safe' micro laser for high resolution three-dimensional laser-mapping. The recently developed and patented 'chip' laser will allow the realisation of a compact, enhanced range laser-radar with unmatched resolution.
Enhanced sensitivity of electrospray ionization mass spectrometry. Enhanced sensitivity of electrospray ionization mass spectrometry. This project aims to enhance the sensitivity of nano-electrospray ionization mass spectrometry (nanoESI-MS) by an order of magnitude by simultaneously overcoming the two interdependent limitations in ion generation and transmission efficiency. This project will design glass capillaries and tubes with complex structures to enable both multiplexing ion generation fr ....Enhanced sensitivity of electrospray ionization mass spectrometry. Enhanced sensitivity of electrospray ionization mass spectrometry. This project aims to enhance the sensitivity of nano-electrospray ionization mass spectrometry (nanoESI-MS) by an order of magnitude by simultaneously overcoming the two interdependent limitations in ion generation and transmission efficiency. This project will design glass capillaries and tubes with complex structures to enable both multiplexing ion generation from a single capillary and geometrically matching the bore of the tube collecting the emitted ion plume. NanoESI-MS has become an indispensable analytical tool for proteomics and synthetic chemistry. The significant enhancement of nanoESI-MS sensitivity in this project is expected to accelerate progress in disease research, biomarker discovery and drug development.Read moreRead less
Foundation technology for quantum measurement, sensing and computing. This project will advance quantum control of cold ions, atoms and diamond colour centres for application of quantum science to high-tech problems, from ion-based quantum computing to diamond-based quantum imaging inside living cells.
Optical technology for quantum science. This project aims to develop and commercialise optical cavity and frequency stabilisation technology to generate laser light at new and precise wavelengths. Australia plays a leading role internationally in quantum science, a burgeoning area of research where fundamental quantum mechanical principles underpin exciting new technological applications, such as ion-based quantum computing, ultracold atom sensing for geo-exploration and defence, and nanoscale i ....Optical technology for quantum science. This project aims to develop and commercialise optical cavity and frequency stabilisation technology to generate laser light at new and precise wavelengths. Australia plays a leading role internationally in quantum science, a burgeoning area of research where fundamental quantum mechanical principles underpin exciting new technological applications, such as ion-based quantum computing, ultracold atom sensing for geo-exploration and defence, and nanoscale imaging inside living human cells. This project aims to continue and develop this role.Read moreRead less
New developments in 3D electrical resistivity imaging of the shallow subsurface. This project is concerned with developing improved procedures for electrical imaging of hidden geological features in the subsurface. These techniques are required to solve urgent problems associated with important issues, such as natural hazards, disposal of dangerous waste, groundwater and construction of major buildings and tunnels. The project will develop new hardware, software and interpretation aids, as well ....New developments in 3D electrical resistivity imaging of the shallow subsurface. This project is concerned with developing improved procedures for electrical imaging of hidden geological features in the subsurface. These techniques are required to solve urgent problems associated with important issues, such as natural hazards, disposal of dangerous waste, groundwater and construction of major buildings and tunnels. The project will develop new hardware, software and interpretation aids, as well as providing postgraduate training in an area of vital national importance.Read moreRead less