Fluorine-labelled proteins for NMR spectroscopy. The technique developed in this project has direct impact on pharmaceutical research: NMR spectroscopy is used routinely to identify chemical compounds that bind to protein targets. This project includes the development of novel assignment techniques of 19F-labelled proteins, so that 19F-NMR can be used to detect specific binding interactions. One of the methods proposed here is designed to reveal structural information about the binding mode in s ....Fluorine-labelled proteins for NMR spectroscopy. The technique developed in this project has direct impact on pharmaceutical research: NMR spectroscopy is used routinely to identify chemical compounds that bind to protein targets. This project includes the development of novel assignment techniques of 19F-labelled proteins, so that 19F-NMR can be used to detect specific binding interactions. One of the methods proposed here is designed to reveal structural information about the binding mode in solution with atomic detail. This knowledge can significantly accelerate drug development. It is otherwise only available from crystal structures that can not always be determined.Read moreRead less
Parallel and Distributed Machine Learning - Smart Data Analysis in the Multicore Era. In large data centres our research will lead to reduced energy consumption by using graphics cards which have a much better computation to power ratio than traditional processors. On desktop computers, it will make machine learning practical by enabling efficient algorithms for spam filtering and content analysis. On networked systems it will lead to distributed inference, caching and collaborative filtering ap ....Parallel and Distributed Machine Learning - Smart Data Analysis in the Multicore Era. In large data centres our research will lead to reduced energy consumption by using graphics cards which have a much better computation to power ratio than traditional processors. On desktop computers, it will make machine learning practical by enabling efficient algorithms for spam filtering and content analysis. On networked systems it will lead to distributed inference, caching and collaborative filtering applications which will both reduced the bandwidth required and make the internet safer for users. Finally, it will enable rapid deployment of sensor networks for monitoring and detection, such as for environmental monitoring and safeguarding Australia's borders.Read moreRead less
ARC Research Network on Intelligent Sensors, Sensor Networks and Information Processing. Sensor networks, a collection of diverse sensors interconnected via an ad-hoc communication network, are identified as one of the key technologies that over the next two decades will change the way we live. This research network brings together an interdisciplinary team of outstanding Australian researchers representing all the key disciplines required to successfully deploy sensor networks and links this te ....ARC Research Network on Intelligent Sensors, Sensor Networks and Information Processing. Sensor networks, a collection of diverse sensors interconnected via an ad-hoc communication network, are identified as one of the key technologies that over the next two decades will change the way we live. This research network brings together an interdisciplinary team of outstanding Australian researchers representing all the key disciplines required to successfully deploy sensor networks and links this team with the foremost international authorities and leading industry players in the area of sensor networks. This research network will guide collaborative research that will ensure Australia to play a world leading role in sensor network development and implementation.
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Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0346878
Funder
Australian Research Council
Funding Amount
$190,000.00
Summary
GeoWulf: An Inference Engine for Complex Earth Systems. The project is to build a `Beowulf' cluster as a platform for solving
complex data inference problems in the Earth sciences, and in
particular the fields of thermochronology, seismology, crustal and
mantle dynamics, and landform evolution. A Beowulf cluster is a
network-linked set of commonly available `off-the-shelf' PC-computers
configured to give unprecedented performance/cost ratio. Projects
using the Beowulf facility will combine ....GeoWulf: An Inference Engine for Complex Earth Systems. The project is to build a `Beowulf' cluster as a platform for solving
complex data inference problems in the Earth sciences, and in
particular the fields of thermochronology, seismology, crustal and
mantle dynamics, and landform evolution. A Beowulf cluster is a
network-linked set of commonly available `off-the-shelf' PC-computers
configured to give unprecedented performance/cost ratio. Projects
using the Beowulf facility will combine state-of-the-art computational
techniques recently developed at ANU, and high quality data sets
collected over the past decade to address fundamental questions in
the Geosciences.Read moreRead less
Optimising seasonal decisions for environmental water use. This project will develop a tool to optimise the use of environmental water, drawing on seasonal forecasts of streamflow and water price, and predicted ecological responses to changing flows. This tool will strengthen the effectiveness of the government organisations responsible for managing Australia's environmental water reserves.
Computer Vision Optimization Problems Using Machine Learning. Computer Vision concerns itself with understanding the world through the analysis of images obtained by a video or still camera. An important application is tracking of people in video and modelling their movements. This has evident applications in security, sport and entertainment. By enabling the computer to capture the motion of a subject in a video, we may detect suspicious activity in security, analyze the motion (golf-swing, ....Computer Vision Optimization Problems Using Machine Learning. Computer Vision concerns itself with understanding the world through the analysis of images obtained by a video or still camera. An important application is tracking of people in video and modelling their movements. This has evident applications in security, sport and entertainment. By enabling the computer to capture the motion of a subject in a video, we may detect suspicious activity in security, analyze the motion (golf-swing, diving style) of a sports-person, or capture the motion of an actor for animation or game applications. Development of a reliable technology requires new optimization techniques, which will place Australia at the forefront of the application of such research, commercially and for the public benefit.Read moreRead less
Development of methods and algorithms to support multidisciplinary optimisation. This project will aim to develop a number of novel and computationally efficient schemes to deal with the key challenges facing multidisciplinary optimisation. These advancements will allow us to solve a number of challenging and intractable problems in science and engineering.
Frontiers in inference about risk. The project aims to develop new methods for robust risk evaluation and minimisation under various constraints and scenarios. Risk evaluation, estimation and prediction using past data is a central activity in diverse areas such as finance, insurance, superannuation and environmental regulation. The project aims to propose and solve innovatively robust risk optimisation problems under constraints, taking into account the time dynamics. Applications include risk ....Frontiers in inference about risk. The project aims to develop new methods for robust risk evaluation and minimisation under various constraints and scenarios. Risk evaluation, estimation and prediction using past data is a central activity in diverse areas such as finance, insurance, superannuation and environmental regulation. The project aims to propose and solve innovatively robust risk optimisation problems under constraints, taking into account the time dynamics. Applications include risk management around natural catastrophes and long-term asset investment of pension funds. The solutions and outcomes are expected to deliver optimal resource allocation proposals and better management of risk exposure in practice.Read moreRead less
Data Adaptive Geophysical Inversion. The goal of this project is to develop new techniques for extracting information about the interior structure of the Earth from large geophysical data sets. These methods will be adaptive so that they allow the definition of the physical model to be constrained by the character of the data. The project will utilize advances in computational geometry, nonlinear inversion and interactive computer visualisation to extract robust information from data sets with v ....Data Adaptive Geophysical Inversion. The goal of this project is to develop new techniques for extracting information about the interior structure of the Earth from large geophysical data sets. These methods will be adaptive so that they allow the definition of the physical model to be constrained by the character of the data. The project will utilize advances in computational geometry, nonlinear inversion and interactive computer visualisation to extract robust information from data sets with variable resolving power. The resulting algorithms will be applicable to a wide range of problems in the physical sciences.Read moreRead less
Intriguing aerodynamics of bees, hoverflies and beyond. Nature observers have long been fascinated by the elegance, agility and endurance of flying insects, but still human-engineered vehicles fail to match their performance. This project aims to reveal the key physical aspects that allow two different insects to fly so well and thus unlock greater performance for flapping flight vehicles beyond insects.