Fluorine-labelled proteins for NMR spectroscopy. The technique developed in this project has direct impact on pharmaceutical research: NMR spectroscopy is used routinely to identify chemical compounds that bind to protein targets. This project includes the development of novel assignment techniques of 19F-labelled proteins, so that 19F-NMR can be used to detect specific binding interactions. One of the methods proposed here is designed to reveal structural information about the binding mode in s ....Fluorine-labelled proteins for NMR spectroscopy. The technique developed in this project has direct impact on pharmaceutical research: NMR spectroscopy is used routinely to identify chemical compounds that bind to protein targets. This project includes the development of novel assignment techniques of 19F-labelled proteins, so that 19F-NMR can be used to detect specific binding interactions. One of the methods proposed here is designed to reveal structural information about the binding mode in solution with atomic detail. This knowledge can significantly accelerate drug development. It is otherwise only available from crystal structures that can not always be determined.Read moreRead less
Parallel and Distributed Machine Learning - Smart Data Analysis in the Multicore Era. In large data centres our research will lead to reduced energy consumption by using graphics cards which have a much better computation to power ratio than traditional processors. On desktop computers, it will make machine learning practical by enabling efficient algorithms for spam filtering and content analysis. On networked systems it will lead to distributed inference, caching and collaborative filtering ap ....Parallel and Distributed Machine Learning - Smart Data Analysis in the Multicore Era. In large data centres our research will lead to reduced energy consumption by using graphics cards which have a much better computation to power ratio than traditional processors. On desktop computers, it will make machine learning practical by enabling efficient algorithms for spam filtering and content analysis. On networked systems it will lead to distributed inference, caching and collaborative filtering applications which will both reduced the bandwidth required and make the internet safer for users. Finally, it will enable rapid deployment of sensor networks for monitoring and detection, such as for environmental monitoring and safeguarding Australia's borders.Read moreRead less
Regularisation methods of inverse problems: theory and computation. This project aims to investigate regularisation methods for inverse problems which are ill-posed in the sense that their solutions depend discontinuously on the data. When only noisy data is available, regularisation methods define stable approximate solutions by replacing the original inverse problem with a family of well-posed neighbouring problems monitored by a so-called regularisation parameter. The project expects to devel ....Regularisation methods of inverse problems: theory and computation. This project aims to investigate regularisation methods for inverse problems which are ill-posed in the sense that their solutions depend discontinuously on the data. When only noisy data is available, regularisation methods define stable approximate solutions by replacing the original inverse problem with a family of well-posed neighbouring problems monitored by a so-called regularisation parameter. The project expects to develop purely data-driven rules to choose the regularisation parameter and show how they work in theory, and in practice. It will also develop convex framework, acceleration strategies as well as preconditioning and splitting ideas to design efficient regularisation solvers.Read moreRead less
ARC Research Network on Intelligent Sensors, Sensor Networks and Information Processing. Sensor networks, a collection of diverse sensors interconnected via an ad-hoc communication network, are identified as one of the key technologies that over the next two decades will change the way we live. This research network brings together an interdisciplinary team of outstanding Australian researchers representing all the key disciplines required to successfully deploy sensor networks and links this te ....ARC Research Network on Intelligent Sensors, Sensor Networks and Information Processing. Sensor networks, a collection of diverse sensors interconnected via an ad-hoc communication network, are identified as one of the key technologies that over the next two decades will change the way we live. This research network brings together an interdisciplinary team of outstanding Australian researchers representing all the key disciplines required to successfully deploy sensor networks and links this team with the foremost international authorities and leading industry players in the area of sensor networks. This research network will guide collaborative research that will ensure Australia to play a world leading role in sensor network development and implementation.
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Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0346878
Funder
Australian Research Council
Funding Amount
$190,000.00
Summary
GeoWulf: An Inference Engine for Complex Earth Systems. The project is to build a `Beowulf' cluster as a platform for solving
complex data inference problems in the Earth sciences, and in
particular the fields of thermochronology, seismology, crustal and
mantle dynamics, and landform evolution. A Beowulf cluster is a
network-linked set of commonly available `off-the-shelf' PC-computers
configured to give unprecedented performance/cost ratio. Projects
using the Beowulf facility will combine ....GeoWulf: An Inference Engine for Complex Earth Systems. The project is to build a `Beowulf' cluster as a platform for solving
complex data inference problems in the Earth sciences, and in
particular the fields of thermochronology, seismology, crustal and
mantle dynamics, and landform evolution. A Beowulf cluster is a
network-linked set of commonly available `off-the-shelf' PC-computers
configured to give unprecedented performance/cost ratio. Projects
using the Beowulf facility will combine state-of-the-art computational
techniques recently developed at ANU, and high quality data sets
collected over the past decade to address fundamental questions in
the Geosciences.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC200100009
Funder
Australian Research Council
Funding Amount
$4,861,236.00
Summary
ARC Training Centre in Optimisation Technologies, Integrated Methodologies, and Applications (OPTIMA). OPTIMA addresses industry’s urgent need for decision-making tools for global competitiveness: reducing lead times, and financial and environmental costs, while improving efficiency, quality, and agility. Despite strong expertise in academia, industry is yet to fully benefit from optimisation technology due to its high barrier to entry. Connecting industry partners with world-leading interdiscip ....ARC Training Centre in Optimisation Technologies, Integrated Methodologies, and Applications (OPTIMA). OPTIMA addresses industry’s urgent need for decision-making tools for global competitiveness: reducing lead times, and financial and environmental costs, while improving efficiency, quality, and agility. Despite strong expertise in academia, industry is yet to fully benefit from optimisation technology due to its high barrier to entry. Connecting industry partners with world-leading interdisciplinary researchers and talented students, OPTIMA will advance an industry-ready optimisation toolkit, while training a new generation of industry practitioners and over 120 young researchers, vanguarding a highly skilled workforce of change agents for transformation of the advanced manufacturing, energy resources, and critical infrastructure sectors.Read moreRead less
Optimising seasonal decisions for environmental water use. This project will develop a tool to optimise the use of environmental water, drawing on seasonal forecasts of streamflow and water price, and predicted ecological responses to changing flows. This tool will strengthen the effectiveness of the government organisations responsible for managing Australia's environmental water reserves.
Computer Vision Optimization Problems Using Machine Learning. Computer Vision concerns itself with understanding the world through the analysis of images obtained by a video or still camera. An important application is tracking of people in video and modelling their movements. This has evident applications in security, sport and entertainment. By enabling the computer to capture the motion of a subject in a video, we may detect suspicious activity in security, analyze the motion (golf-swing, ....Computer Vision Optimization Problems Using Machine Learning. Computer Vision concerns itself with understanding the world through the analysis of images obtained by a video or still camera. An important application is tracking of people in video and modelling their movements. This has evident applications in security, sport and entertainment. By enabling the computer to capture the motion of a subject in a video, we may detect suspicious activity in security, analyze the motion (golf-swing, diving style) of a sports-person, or capture the motion of an actor for animation or game applications. Development of a reliable technology requires new optimization techniques, which will place Australia at the forefront of the application of such research, commercially and for the public benefit.Read moreRead less
Development of methods and algorithms to support multidisciplinary optimisation. This project will aim to develop a number of novel and computationally efficient schemes to deal with the key challenges facing multidisciplinary optimisation. These advancements will allow us to solve a number of challenging and intractable problems in science and engineering.
Optimisation of piezoelectric metamaterials: Towards robotic stress sensors. This project aims to design new piezoelectric material microstructures that can enhance the measurement of complex local stress states within robotic limbs. The project expects to generate new knowledge of the achievable properties of multi-poled piezoelectric materials and develop computational tools for the analysis and structural optimisation of such materials. The designed microstructures may revolutionise piezoelec ....Optimisation of piezoelectric metamaterials: Towards robotic stress sensors. This project aims to design new piezoelectric material microstructures that can enhance the measurement of complex local stress states within robotic limbs. The project expects to generate new knowledge of the achievable properties of multi-poled piezoelectric materials and develop computational tools for the analysis and structural optimisation of such materials. The designed microstructures may revolutionise piezoelectric sensor technology. Expected outcomes include manufactured proof-of-concept sensors that enable measurement of local stress fields. This should provide significant benefits, such as improved future robot capability and reliability, and research training for next-generation Australian computational mathematicians. Read moreRead less