Molecular Mechanisms That Generate And Activate Muscle Stem Cells During Growth And Disease.
Funder
National Health and Medical Research Council
Funding Amount
$596,086.00
Summary
This study aims answer long standing questions in the field of muscle stem cells. Understanding how stem cell-driven muscle repair occurs has profound implications for our understanding of the pathology and treatment of muscle disease. Muscular dystrophies and myopathies are amongst the largest group of inherited disorders to afflict the human condition. It is our hope that the results of this research will lead to a better understanding of how treatments, stem cell based or otherwise, could be ....This study aims answer long standing questions in the field of muscle stem cells. Understanding how stem cell-driven muscle repair occurs has profound implications for our understanding of the pathology and treatment of muscle disease. Muscular dystrophies and myopathies are amongst the largest group of inherited disorders to afflict the human condition. It is our hope that the results of this research will lead to a better understanding of how treatments, stem cell based or otherwise, could be employed to correct such disorders.Read moreRead less
Seeing Is Believing: Imaging Muscle Maintenance And Repair
Funder
National Health and Medical Research Council
Funding Amount
$727,191.00
Summary
We will characterise the behaviour of muscle stem cells in vivo within their micro-environment in normal and regenerating adult muscles, using high-end imaging technologies and mouse lines that we recently created. This will allow correlating cellular behaviours with the activation of signaling pathways, chosen for their likely role in the activation of satellite cells. We will then modulate the activity of these pathways in the satellite cell niche to evaluate their function.
SEA-URCHIN: South East Asia - Using Research For Change In Hospital-acquired Infection In Neonates
Funder
National Health and Medical Research Council
Funding Amount
$2,303,773.00
Summary
Each year, more than one million babies die from infection before they reach one month of age. Proven and inexpensive practices to prevent and treat infection exist but they are not always followed (eg hand washing). This research will evaluate the impact of tailored implementation strategies on rates of infection and death in the neonatal units of nine hospitals in four counties in South East Asia. Staff from these units will work with Australian partners to devise, implement and evaluate diffe ....Each year, more than one million babies die from infection before they reach one month of age. Proven and inexpensive practices to prevent and treat infection exist but they are not always followed (eg hand washing). This research will evaluate the impact of tailored implementation strategies on rates of infection and death in the neonatal units of nine hospitals in four counties in South East Asia. Staff from these units will work with Australian partners to devise, implement and evaluate different strategies.Read moreRead less
Pathways To Prevention: The Effectiveness Of Universal And Selective Prevention In Altering Developmental Pathways To Alcohol And Cannabis Related Harms In Young Adults
Funder
National Health and Medical Research Council
Funding Amount
$465,967.00
Summary
This project will assess the potential long-term benefits for young Australians of two school-based drug prevention programs (Climate Schools and Preventure) compared to drug education as usual. This world-first study will inform national and international policy by evaluating whether prevention programs delivered in Year 8 are effective in reducing alcohol and cannabis related harms, including risk of aggression and violence, over the high risk period during young adulthood (ages 18-20).
Antibiotic resistance is a looming public health crisis. New antibiotics with new mechanisms of action are desperately needed. The long-term goal of this research is to develop new drugs that disarm bacteria to overcome the problem of antibiotic resistance.
A RCT Of Depression Prevention In Adolescents: The Future Proofing Trial
Funder
National Health and Medical Research Council
Funding Amount
$2,183,738.00
Summary
Prevention is better than cure. Adolescence is when 50% of mental health problems emerge. We know we can prevent depression in 22% of young people at risk. However, the major problem is providing these prevention interventions easily and universally. Using 20,000 young people, this research aims to discover how to use smartphones to deliver prevention interventions in the real world, to improve prevention rates, and to determine the triggers associated with the onset of mental health problems.
Assessing The Impact Of A Multi-component Intervention To Improve Dietary Intake Of Indigenous Australian Children And Their Families Living In Remote Communities
Funder
National Health and Medical Research Council
Funding Amount
$1,455,043.00
Summary
Sugar-sweetened beverage consumption seems to contribute to obesity and diabetes. We aim to test the impact of multi-component intervention including a school-based nutrition education program combining high levels of parental involvement plus a supportive environment to reduce sugar-sweetened beverage consumption and improve healthy eating among Indigenous Australian children and their families living in remote communities.
Developmental Schizotypy In The General Population: Early Risk Factors And Predictive Utility.
Funder
National Health and Medical Research Council
Funding Amount
$830,952.00
Summary
This study will determine early childhood risk factors for psychosis-proneness in children aged 11 years, and emerging signs and symptoms of mental health disorders of these children, using population data from the NSW Child Development Study. Determining risk for psychosis as early as possible in the life course will enable the provision of preventative interventions to children at critical points in development.
Development Of Next Generation Drugs For Chronic Myeloid Leukaemia
Funder
National Health and Medical Research Council
Funding Amount
$632,726.00
Summary
Chronic myeloid leukaemia (CML) is one of the four most common types of leukaemia. With current therapies, 15–20% of patients newly diagnosed for CML will die in the next five years, and it is therefore vitally important to discover new treatments. The aim of this project is to develop a new generation of drugs to treat CML based on new approaches (i.e., different type of molecules and different binding site) that can combat the resistance acquired to the current treatments.
Suicide Prevention In Schools: A Social Connectedness Approach
Funder
National Health and Medical Research Council
Funding Amount
$825,989.00
Summary
Suicide is the leading cause of death in Australians aged 15-24 years. This project will investigate the effectiveness of an intervention to promote help-seeking for suicidal behaviours in adolescence. Taking a whole school approach, peer leaders in 16 Australian high schools will receive training in the Sources of Strength program. The primary aim of the project is to determine whether peer leadership training and messaging improves help-seeking attitudes, intentions and behaviour for suicide.