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Dissecting The Molecular Mechanisms Underlying Muscle Pathology In Duchenne Muscular Dystrophy (DMD)
Funder
National Health and Medical Research Council
Funding Amount
$375,856.00
Summary
Duchenne Muscular Dystrophy (DMD) is a genetic disease affecting 1-3,500 newborn males worldwide annually. The disease is characterized by muscle wasting, subsequently resulting in fatality in the late teens to the late 20's. To date there is no cure and treatments are aimed improving quality of life. This project focuses on examining the mechanisms behind the disease to ultimately gain a better understanding in order to develop more effective therapies for the treatment of DMD.
Molecular Mechanisms That Generate And Activate Muscle Stem Cells During Growth And Disease.
Funder
National Health and Medical Research Council
Funding Amount
$596,086.00
Summary
This study aims answer long standing questions in the field of muscle stem cells. Understanding how stem cell-driven muscle repair occurs has profound implications for our understanding of the pathology and treatment of muscle disease. Muscular dystrophies and myopathies are amongst the largest group of inherited disorders to afflict the human condition. It is our hope that the results of this research will lead to a better understanding of how treatments, stem cell based or otherwise, could be ....This study aims answer long standing questions in the field of muscle stem cells. Understanding how stem cell-driven muscle repair occurs has profound implications for our understanding of the pathology and treatment of muscle disease. Muscular dystrophies and myopathies are amongst the largest group of inherited disorders to afflict the human condition. It is our hope that the results of this research will lead to a better understanding of how treatments, stem cell based or otherwise, could be employed to correct such disorders.Read moreRead less
Seeing Is Believing: Imaging Muscle Maintenance And Repair
Funder
National Health and Medical Research Council
Funding Amount
$727,191.00
Summary
We will characterise the behaviour of muscle stem cells in vivo within their micro-environment in normal and regenerating adult muscles, using high-end imaging technologies and mouse lines that we recently created. This will allow correlating cellular behaviours with the activation of signaling pathways, chosen for their likely role in the activation of satellite cells. We will then modulate the activity of these pathways in the satellite cell niche to evaluate their function.
Roles Of Vitamin D In Skeletal Muscle And Satellite Cells
Funder
National Health and Medical Research Council
Funding Amount
$380,891.00
Summary
Vitamin D deficiency leads to muscle pain and weakness that are reversible with vitamin D supplementation. However, precise biological effects of vitamin D in skeletal muscle are unclear. In this fellowship, novel mouse models and innovative techniques will be used to examine vitamin D signalling pathways in whole muscle and muscle stem cells. Ultimately, the therapeutic potential of the vitamin D pathway in treatment of muscle disorders and age-related muscle wasting will be explored.
An Exploration Of The Nature And Meaning Of Informal Communities In Cancer Treatment
Funder
National Health and Medical Research Council
Funding Amount
$92,745.00
Summary
The interactions that occur in cancer treatment with other patients, family members and staff are often unavoidable. Recent research examining patient's interactions has demonstrated the importance of these communications, as social support, a forum to exchange information and ideas, and a gathering of people facing the same challenges. This study aims to examine the role of these interactions between patients, staff and family members to explore the purposes and effects of these interactions.
Creating Sustainable Healthcare: Ensuring New Diagnostics Avoid Harms, Improve Outcomes, And Direct Resources Wisely
Funder
National Health and Medical Research Council
Funding Amount
$2,497,658.00
Summary
Novel imaging, biomarkers and genomic tests for risk assessment and early detection are emerging as major forces for change in clinical practice. While providing advances and new benefits for patients, new technologies can also have harmful, unintended consequences - overdiagnosis and overtreatment. This multidisciplinary CRE will investigate how to respond to emerging technologies to optimise health outcomes while avoiding harms and directing healthcare resources wisely.
Developing Evidence Based Strategies For Addressing Childhood Vaccination Rejection
Funder
National Health and Medical Research Council
Funding Amount
$743,927.00
Summary
Parental rejection of vaccines is a global concern that threatens to undermine disease control. A lack of evidence hampers the responses to this complex and persistent problem. We will interview parents who don’t vaccinate their children to learn what influences their decisions. We will then hold community juries and a public engagement process to refine strategies for responding to vaccination rejection that are acceptable to a well informed citizenry, practical and ethically justified.
Mobile Intervention For Drinking In Young People (MIDY): Randomised Controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$403,378.00
Summary
Binge drinking is a significant health and social issue in Australia. In this innovative trial, we will communicate with young people via their mobile phones while they are on a night out. Young people will send hourly information about their drinking and will receive a relevant message in response, encouraging them to slow down or avoid harmful activities. The methods and the messages were developed in partnership with young people and have been tested in real drinking situations.