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Molecular Cell Biology and Comparative Genomics Of Planctomycetes and Verrucomicrobia In Relation To Evolution Of Cytoskeletal Proteins and Membrane-bounded Compartments. Planctomycetes and verrucomicrobia are evolutionarily distinct groups of bacteria which possess unusual cell structure and which share some significant genes important in cell biology with eukaryotes e.g. in verrucomicrobia the cytoskeleton protein tubulin. These bacteria are important for understanding the transition from no ....Molecular Cell Biology and Comparative Genomics Of Planctomycetes and Verrucomicrobia In Relation To Evolution Of Cytoskeletal Proteins and Membrane-bounded Compartments. Planctomycetes and verrucomicrobia are evolutionarily distinct groups of bacteria which possess unusual cell structure and which share some significant genes important in cell biology with eukaryotes e.g. in verrucomicrobia the cytoskeleton protein tubulin. These bacteria are important for understanding the transition from non-nucleated cells with simple cell division to nucleated cells with chromosome separation via cytoskeletal protein movement.The project will compare genomes of of planctomycetes and verrucomicrobia to determine their relationship, determine whether the tubulin homolog of verrucomicrobia can form cytoskeleton structures, and characterize the cytoskeleton of ammonium-oxidizing planctomycetes used in wastewater treatment.Read moreRead less
Biological phosphorous removal for wastewater treatment. The aim is to provide a scientific basis for understanding how phosphorous can be removed in wastewater treatment plants, using environmentally safe biological methods rather than by using chemicals. This is expected to lead to improved performance in wastewater treatment plants, which will be of economic and environmental benefit, particularly to regional communities in inland Australia.
Arsenite oxidation by a novel bacterium that is a candidate for arsenic bioremediation. The arsenic munching microbe NT-26 could help in the fight to clean up arsenic-contaminated mining waste and drinking water. Arsenic poses an environmental problem in countries such as Australia, USA and Canada owing primarily to mining activities. The problem in countries such as Bangladesh and West Bengal are even more serious as these people are dying of arsenic-related diseases as they rely on water conta ....Arsenite oxidation by a novel bacterium that is a candidate for arsenic bioremediation. The arsenic munching microbe NT-26 could help in the fight to clean up arsenic-contaminated mining waste and drinking water. Arsenic poses an environmental problem in countries such as Australia, USA and Canada owing primarily to mining activities. The problem in countries such as Bangladesh and West Bengal are even more serious as these people are dying of arsenic-related diseases as they rely on water containing arsenic as their primary source of drinking water. The outcomes of this research should provide the necessary information for removing arsenic from all types of waters.Read moreRead less
Novel coding and decoding in suspension arrays for accelerated biomolecular discovery and personalised medicine. This project will establish an advanced multiplexing technique to rapidly analyse complex biological mixtures, such as cell lysates, food samples or body fluids. It will enable the analysis of not tens, but thousands or more distinctive molecular targets in a single test. This will build the foundations for future generation bioassays, paving the way to emerging personalised medicine. ....Novel coding and decoding in suspension arrays for accelerated biomolecular discovery and personalised medicine. This project will establish an advanced multiplexing technique to rapidly analyse complex biological mixtures, such as cell lysates, food samples or body fluids. It will enable the analysis of not tens, but thousands or more distinctive molecular targets in a single test. This will build the foundations for future generation bioassays, paving the way to emerging personalised medicine. This will lead to new personal diagnostics tools for rapid genotype profiling, to better tailor therapy to the individual patient's specific characteristics. As well as the potential to improve health outcomes, the project will generate significant intellectual property and the opportunity for development of new diagnostic instrumentation in Australia.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100015
Funder
Australian Research Council
Funding Amount
$200,000.00
Summary
Purchase of an ultra-performance liquid chromatograph - triple quadrupole mass spectrometer. The diverse research supported by the proposed instrument group addresses several national research priorities. It will lead to a better fundamental understanding of the hormonal control of plant growth, improved catalysts for organic synthesis including pharmaceuticals and improved food safety. In forestry it will help to increase forest productivity through mitigating losses from insect and mamm ....Purchase of an ultra-performance liquid chromatograph - triple quadrupole mass spectrometer. The diverse research supported by the proposed instrument group addresses several national research priorities. It will lead to a better fundamental understanding of the hormonal control of plant growth, improved catalysts for organic synthesis including pharmaceuticals and improved food safety. In forestry it will help to increase forest productivity through mitigating losses from insect and mammalian pests and enhancing wood quality. In pharmaceutics, improved treatments for asthma are expected. This facility will provide the infrastructure essential for many researchers to maintain internationally competitive profiles in their areas and continue to offer postgraduate training and postdoctoral opportunities.Read moreRead less
Complex Motion Processing in Primate Visual Cortex. As we move through the world, a dynamic visual image is projected onto our retinas. The pattern of movement in the retinal image contains information about three-dimensional structure in the environment and the time of impending collisions. Our visual systems are expert at exploiting this information, enabling us to navigate through complex visual environments at a level far beyond the most sophisticated artificial systems. We plan to investiga ....Complex Motion Processing in Primate Visual Cortex. As we move through the world, a dynamic visual image is projected onto our retinas. The pattern of movement in the retinal image contains information about three-dimensional structure in the environment and the time of impending collisions. Our visual systems are expert at exploiting this information, enabling us to navigate through complex visual environments at a level far beyond the most sophisticated artificial systems. We plan to investigate complex motion processing in the primate brain by recording the responses of neurons in identified regions of the visual cortex of macaque monkeys to a range of behaviourally relevant motion stimuli.Read moreRead less
Postgenomic perspectives on human nature. The rapid growth of biological knowledge and the need for societal reflection on this knowledge and its applications in Australia and overseas make it increasingly urgent that the humanities and social sciences draw on a biologically credible vision of human nature. We will study how non-scientists understand human nature and compare their ideas to those of scientists from a range of different disciplines. We will examine what current biology reveals abo ....Postgenomic perspectives on human nature. The rapid growth of biological knowledge and the need for societal reflection on this knowledge and its applications in Australia and overseas make it increasingly urgent that the humanities and social sciences draw on a biologically credible vision of human nature. We will study how non-scientists understand human nature and compare their ideas to those of scientists from a range of different disciplines. We will examine what current biology reveals about the biological basis of human characteristics and develop an account of human nature that is defensible in the light of that knowledge.Read moreRead less
Biohumanities: Philosophical, Historical, and Socio-Cultural Studies of Contemporary Bioscience. Improving understanding of the meaning and implications of contemporary bioscience, especially genetics and molecular biology, through bioliterate research in the humanities and social sciences, and conversely through better assimilation of bioscience and its significance by the humanities and social sciences. The research will be conducted in close collaboration with the Australian scientific commun ....Biohumanities: Philosophical, Historical, and Socio-Cultural Studies of Contemporary Bioscience. Improving understanding of the meaning and implications of contemporary bioscience, especially genetics and molecular biology, through bioliterate research in the humanities and social sciences, and conversely through better assimilation of bioscience and its significance by the humanities and social sciences. The research will be conducted in close collaboration with the Australian scientific community and will be disseminated back to the scientific community, to the humanities and to the Australian public. The project will bring to Australia the strengths of the applicant's existing collaborations with leading research centres in this field in the USA, UK and Canada.Read moreRead less
The mechanism of water splitting in photosynthesis. Sunlight reaching the earth is used by the vast body of plants and algae living in surface waters and on the land to drive photosynthesis. One of the most fundamental contributions that photosynthesis provides to the Biosphere is the gaseous oxygen produced by its water-splitting chemistry - ~300 gigatons of O2 are released into the atmosphere per year. However, the mechanism behind water-splitting is not precisely known. We will use a range o ....The mechanism of water splitting in photosynthesis. Sunlight reaching the earth is used by the vast body of plants and algae living in surface waters and on the land to drive photosynthesis. One of the most fundamental contributions that photosynthesis provides to the Biosphere is the gaseous oxygen produced by its water-splitting chemistry - ~300 gigatons of O2 are released into the atmosphere per year. However, the mechanism behind water-splitting is not precisely known. We will use a range of unique experimental approaches to determine the molecular mechanism of the photosynthetic water-splitting chemistry. The understanding of this reaction will provide the molecular blueprint for the development of efficient biocatalysts to generate H2 and O2 from water.Read moreRead less
The Late Pleistocene Peopling of East Asia and Associated Climate-Environment History. This project will contribute to an environmentally sustainable Australia through understanding the long-term history of climate change centred on the monsoon weather system and the scale and magnitude of environmental change and its long-term impacts on human inhabitants in East Asia and Australasia. It helps to safeguard Australia by enhancing our capacity to interpret and engage with our region through great ....The Late Pleistocene Peopling of East Asia and Associated Climate-Environment History. This project will contribute to an environmentally sustainable Australia through understanding the long-term history of climate change centred on the monsoon weather system and the scale and magnitude of environmental change and its long-term impacts on human inhabitants in East Asia and Australasia. It helps to safeguard Australia by enhancing our capacity to interpret and engage with our region through greater understanding of societies and cultures. It will improve understanding of the long-term history and relationships of major groups of people across our region. Many benefits will derive from scientific, educational and cultural exchange between Australia and our neighbour China.Read moreRead less