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Successful establishment of pregnancy requires a viable embryo and a receptive uterus. The contribution that reduced uterine receptivity makes to human infertility is unknown. IVF patients with implantation failure will be investigated using different approaches to identify gene pathways that are altered in reduced uterine receptivity. This study could lead to a clinical test for uterine receptivity and help to improve fertility treatment options for women with repeated implantation failure.
Epidemiology And Management Of Bronchiectasis In Australian Adults
Funder
National Health and Medical Research Council
Funding Amount
$124,676.00
Summary
Bronchiectasis is an incurable lung disease which causes chronic cough with phlegm. We do not know how many Australians have bronchiectasis or how it affects their lives, and there are few effective treatments. The recently launched Australian Bronchiectasis Registry collects comprehensive information on Australians with bronchiectasis. This project will use this information to start to answer these questions, and will investigate nebulised hypertonic saline as a cheap and accessible treatment.
Uptake of fertility preservation procedures (eg. egg and embryo freezing) prior to cancer treatment is increasing and women will return to use these to try to conceive. Radiation may damage the uterus and there is insufficient evidence to guide the management of those exposed to intermediate doses. The aim is to improve understanding of radiation effects on the uterus which will assist clinicians with deciding whether it can support a pregnancy, or if surrogacy should be advised.
Understanding The Disruption-driven Clinical Environment To Enable Improvement In Patient Safety
Funder
National Health and Medical Research Council
Funding Amount
$77,150.00
Summary
Medical staff work in busy, often disruptive environments. There is growing evidence that disruptions compromise patient safety, although this process is not well understood. This project aims to use novel statistical methods to elucidate the complex relationship between disruption and adverse patient outcomes. It will enable informed intervention design and provide the tools to accurately assess the impact of such interventions.
The aim of this project is to determine whether melatonin supplementation has an effect on cumulative pregnancy and delivery rates, allowing for the use of frozen embryos obtained during a melatonin treatment cycle. This will be achieved by a series of experiments designed to investigate the effect of melatonin on follicular fluid and culture media as well as assessing clinical pregnancy rates and delivery rates.
A Comparison Of Arthroscopic Synovial Biopsy Based Targeted Biologic Therapy Versus Conventional Therapy In Rheumatoid Arthritis
Funder
National Health and Medical Research Council
Funding Amount
$133,351.00
Summary
This proposed study will investigate if treatment of rheumatoid arthritis (RA) based on biopsy of affected joints’ lining is better than standard therapy (not based on the results of biopsy). Current strategies to treat RA not infrequently result in incomplete disease suppression with potentially resultant joint damage, in part because of lack of definite guidelines to individualise treatment. We propose that therapy on the basis of the analysis of biopsy of joint lining will lead to better dise ....This proposed study will investigate if treatment of rheumatoid arthritis (RA) based on biopsy of affected joints’ lining is better than standard therapy (not based on the results of biopsy). Current strategies to treat RA not infrequently result in incomplete disease suppression with potentially resultant joint damage, in part because of lack of definite guidelines to individualise treatment. We propose that therapy on the basis of the analysis of biopsy of joint lining will lead to better disease control than the currently prevalent approach.Read moreRead less
Individual Differences In Coping With A Diagnosis Of ALS: Psychosocial Adjustment And Implications For Psychological Treatment Planning
Funder
National Health and Medical Research Council
Funding Amount
$101,523.00
Summary
A high proportion of patients with amyotrophic lateral sclerosis develop subtle personality and behavioural changes similar to those with behavioural variant frontotemporal dementia. Apathetic symptoms are the most commonly observed personality change. This project aims to establish the contribution of premorbid personality traits on the development and expression of apathy, and in turn, it’s implications for ALS patients’ psychological wellbeing and response to psychological intervention.
Optimising Therapy In Anti-neutrophil Cytoplasmic Antibody (ANCA) Associated Vasculitis
Funder
National Health and Medical Research Council
Funding Amount
$124,676.00
Summary
ANCA vasculitis is a rare autoimmune condition causing inflammation in small blood vessels, that can lead to organ failure and death. This research will help identify the best treatment approach for different subgroups of patients and the best timing of certain treatments. We will also explore patient symptoms and experience of this condition, and how this relates to disease activity, damage and medication effects.
Impact Of Co-morbidities On Screening, Diagnosis, Treatment And Survival Of Cervical Cancer Amongst Australian Indigenous And Non-Indigenous Women: 1997-2009
Funder
National Health and Medical Research Council
Funding Amount
$98,236.00
Summary
Indigenous women are more likely than non-Indigenous Australian women to be diagnosed with cervical cancer and are less likely to survive it. This study will investigate the impact of co-exisiting chronic diseases (co-morbidities) on cervical cancer screening, diagnosis, treatment and survival outcomes for Indigenous compared to non-Indigenous women. Results from this study will assist in directing future public health initiatives that aim to improve outcomes for women with cervical cancer.
Population-level Vaccine Safety Monitoring: Risk Assessment And Policy Implications
Funder
National Health and Medical Research Council
Funding Amount
$85,649.00
Summary
Vaccines prevent millions of deaths worldwide but events can occur after vaccination which may or may not be related to the vaccine. It is vital to ensure vaccines are safe and that both the public and medical providers remain confident in vaccination programs. The PhD thesis will look at the various methods for monitoring vaccine safety in Australia, and compare the usefulness of each system. This will provide information for policy makers on the safety of vaccines in Australia.