High performance chromatography based on nanostructured monolithic polymers. The proposed project will generate highly significant, fundamental advances in separation science by developing new stationary phases and separation technologies suitable for the analysis of very complex samples which cannot be addressed by current methods. These technologies will be applied in a wide range of areas of national importance including pharmaceutical analysis and drug discovery; environmental, clinical, and ....High performance chromatography based on nanostructured monolithic polymers. The proposed project will generate highly significant, fundamental advances in separation science by developing new stationary phases and separation technologies suitable for the analysis of very complex samples which cannot be addressed by current methods. These technologies will be applied in a wide range of areas of national importance including pharmaceutical analysis and drug discovery; environmental, clinical, and forensic analysis; energy generation and foods. The project will also lead to very significant new intellectual property having extremely high commercial potential worldwide, and thereby generates the promise of considerable direct financial returns to Australia.Read moreRead less
The Synthesis and Analysis of Certain Explosives and Illicit Drugs for Improved Forensic Detection. There is an increasing demand within law enforcement agencies, worldwide, for selective and sensitive methods for the determination of illicit substances. Over the last decade Deakin University chemists have played a major role in establishing the utility of chemiluminescent reactions for the determination of a variety of pharmaceutical opiates in process streams. This project seeks to build upon ....The Synthesis and Analysis of Certain Explosives and Illicit Drugs for Improved Forensic Detection. There is an increasing demand within law enforcement agencies, worldwide, for selective and sensitive methods for the determination of illicit substances. Over the last decade Deakin University chemists have played a major role in establishing the utility of chemiluminescent reactions for the determination of a variety of pharmaceutical opiates in process streams. This project seeks to build upon these successes, in order to develop innovative analytical strategies for forensic detection of certain illicit drugs and explosives. The results of this research have the potential to revolutionise key aspects of forensic analysis.Read moreRead less
Immobilised Lipid Chromatography for Membrane Protein Isolation and Analysis. Current techniques for membrane protein are inadequate for the emerging proteomic challenge, in which approximately 40% of proteins are predicted to be membrane associated. The aim of this proposal is to develop a new approach to purify membrane proteins using our recently-developed immobilised membrane chromatography materials. The present proposal will provide a new high-resolution separation technique that allows is ....Immobilised Lipid Chromatography for Membrane Protein Isolation and Analysis. Current techniques for membrane protein are inadequate for the emerging proteomic challenge, in which approximately 40% of proteins are predicted to be membrane associated. The aim of this proposal is to develop a new approach to purify membrane proteins using our recently-developed immobilised membrane chromatography materials. The present proposal will provide a new high-resolution separation technique that allows isolation and on-line mass analysis of complex mixtures of membrane proteins for subsequent proteomic analysis, high-throughput screening or structural studies and could form the basis for further development of new commercial tools for membrane protein analysis.Read moreRead less
Bioanalytical Microchips Based on Integrated, Application Tailored Monolithic Modules. Microfluidic devices offer substantial advantages over current technology, in terms of speed, cost of analysis, portability, operator simplicity and safety. Integrating multiple analytical processes within a simple and reliable portable device will lead to application in a range of areas, from pharmacology to therapeutic drug monitoring, proteomic and metabolomic screening for disease diagnosis and drug develo ....Bioanalytical Microchips Based on Integrated, Application Tailored Monolithic Modules. Microfluidic devices offer substantial advantages over current technology, in terms of speed, cost of analysis, portability, operator simplicity and safety. Integrating multiple analytical processes within a simple and reliable portable device will lead to application in a range of areas, from pharmacology to therapeutic drug monitoring, proteomic and metabolomic screening for disease diagnosis and drug development, and also for performing clinical diagnostics in a rural area. This will significantly impact on the quality of life of the Nation as a whole, not only due to expedient diagnosis and treatment which has obvious health benefits, but also in the considerable financial benefits that result from early and efficient treatment. Read moreRead less
Synthesis and analysis of equine anabolic steroid metabolites. The Australian Racing Industry has an annual turnover of over $11,000M and is Australia's highest employing industry. Its credibility is dependent upon the enforcement of regulations relating to illicit substances. The aim of the project is to devise testing procedures for illicit drugs in the equine. To achieve this a variety of hydroxylated anabolic steroid equine metabolites are to be synthesised as reference standards and for ....Synthesis and analysis of equine anabolic steroid metabolites. The Australian Racing Industry has an annual turnover of over $11,000M and is Australia's highest employing industry. Its credibility is dependent upon the enforcement of regulations relating to illicit substances. The aim of the project is to devise testing procedures for illicit drugs in the equine. To achieve this a variety of hydroxylated anabolic steroid equine metabolites are to be synthesised as reference standards and for studies on analytical procedures. These analytical studies will involve production of antibodies, and of the appropriate testing procedures.Read moreRead less
Extraction of gold from thiosulfate leach liquors using selective magnetic ion exchange (MIEX) resins. Cyanide processes used for gold leaching can cause severe environmental problems. This proposal studies the use of thiosulfate as an alternative, concentrating on the design and synthesis of new functionalised magnetic ion-exchange resins, which will act as selective adsorbents for the gold thiosulfate complex and thereby facilitate the implementation of this efficient, low environmental impact ....Extraction of gold from thiosulfate leach liquors using selective magnetic ion exchange (MIEX) resins. Cyanide processes used for gold leaching can cause severe environmental problems. This proposal studies the use of thiosulfate as an alternative, concentrating on the design and synthesis of new functionalised magnetic ion-exchange resins, which will act as selective adsorbents for the gold thiosulfate complex and thereby facilitate the implementation of this efficient, low environmental impact process. Since the leaching is typically applied to ores rich in copper, resins for the recovery of copper will also be designed. Laboratory proving trials will be conducted and successful candidates will be considered for future commercialisation of a Resin-in-Pulp leaching and recovery process.Read moreRead less
Novel water treatment technologies for minimisation of bromide and iodide in drinking water. This project will develop innovative new water treatment processes to selectively remove bromide and iodide from potable source waters. The project promotes Australia as a leader in water treatment technology. Successful outcomes will have excellent potential for international commercialisation by spin-off companies and will provide economic benefits and prestige locally. Economic benefits include lower ....Novel water treatment technologies for minimisation of bromide and iodide in drinking water. This project will develop innovative new water treatment processes to selectively remove bromide and iodide from potable source waters. The project promotes Australia as a leader in water treatment technology. Successful outcomes will have excellent potential for international commercialisation by spin-off companies and will provide economic benefits and prestige locally. Economic benefits include lower costs to water utilities through the availability of improved technology for treatment of marginal quality water supplies and improved ability to comply with water quality guidelines. Public perception and confidence in water supply quality will be enhanced, due to reduction in taste and odour issues and disinfection by-products. Read moreRead less
New Enantiomeric Separation Technologies for Natural Product, Pharmaceuticals and Environmental Pollutant Characterisation. Enantiomeric characterisation allows evaluation of drug purity for potentially harmful constituents, consumer protection against adulteration of essential oils and natural materials, and study of chemical interactions in biochemical/environmental systems. Chromatograph technologies (GC, HPLC and CE)for enantioseparation are available, however limitations prevent multicompon ....New Enantiomeric Separation Technologies for Natural Product, Pharmaceuticals and Environmental Pollutant Characterisation. Enantiomeric characterisation allows evaluation of drug purity for potentially harmful constituents, consumer protection against adulteration of essential oils and natural materials, and study of chemical interactions in biochemical/environmental systems. Chromatograph technologies (GC, HPLC and CE)for enantioseparation are available, however limitations prevent multicomponent characterisation of complete sample mixtures. Critical choices involve: choosing a chiral selector that interacts differentially upon all enantiomers; incorporation of selector into high-efficiency chromatographic systems; application to all target compounds in the sample. We will synthesise novel chiral selectors, incorporate these into new separation columns, apply ultra-high resolution 2-dimensional GCxGC to broad-spectrum chiral analysis of volatile chemical samples.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989351
Funder
Australian Research Council
Funding Amount
$425,000.00
Summary
High Resolution Mass Spectrometry Facility. The research that will be supported by this vital infrastructure impacts on the sustainable environment through understanding the process of seed germination and the human condition through new drugs for the treatment of cancer and Parkinson's disease. Fundamental science will also be addressed particularly in the fields of photonics and the nature of interactions between matter.
Strategies for the detection of designer steroids in racehorses. The Australian racing industry drives economic activity and contributes $1 billion to GDP, $151 million Government revenue and 50,000 jobs in NSW. Racing depends on maintaining the highest standards of integrity. This project will make Australia a world leader by developing robust methods to detect designer steroids in thoroughbred racing.