Light Activated Electrochemistry: Microelectrode Arrays with just one wire. Electrochemistry requires each electrode to be connected to the external circuit by a wire. With many electrodes this means many wires. Wires limit electrode density in arrays and dictate that the electrode architecture must be predetermined. This project aims to remove the need for a wire for each electrode by using light to sequentially connect each electrode to a single wire. This will be achieved using modified silic ....Light Activated Electrochemistry: Microelectrode Arrays with just one wire. Electrochemistry requires each electrode to be connected to the external circuit by a wire. With many electrodes this means many wires. Wires limit electrode density in arrays and dictate that the electrode architecture must be predetermined. This project aims to remove the need for a wire for each electrode by using light to sequentially connect each electrode to a single wire. This will be achieved using modified silicon electrodes where irradiating with light causes an increase in conductivity at the illumination spot. The project will explore the variables that influence the spatial resolution and apply the ideas to making soft connects for nanoelectronics and making high density electrode arrays for electroanalysis.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE160100732
Funder
Australian Research Council
Funding Amount
$359,544.00
Summary
Electrostatic Catalysis: guiding reactive interfaces using electric fields. This project seeks to gain quantitative understanding of the role of electrostatics over chemical processes. Chemical transformations of organic compounds at interfaces underpin some of the most important processes, from the production of fine chemicals for pharmaceuticals to assisting bio-degradation of pollutants in clean technologies. Recent computational studies suggest that by applying oriented electric fields at in ....Electrostatic Catalysis: guiding reactive interfaces using electric fields. This project seeks to gain quantitative understanding of the role of electrostatics over chemical processes. Chemical transformations of organic compounds at interfaces underpin some of the most important processes, from the production of fine chemicals for pharmaceuticals to assisting bio-degradation of pollutants in clean technologies. Recent computational studies suggest that by applying oriented electric fields at interfaces, the rate and the selectivity of chemical processes can be altered at will. The project intends to test these theoretical findings. The knowledge generated by this research may translate into new technologies for the fine-chemical and biotechnology industries.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL150100060
Funder
Australian Research Council
Funding Amount
$2,875,097.00
Summary
The first generation of single entity measurement tools for analysis. The first generation of single entity measurement tools for analysis: This fellowship project aims to develop a new type of diagnostic device that measures single molecules or single cells. Such measurements seek to revolutionise analysis by allowing heterogeneity and rare events in samples to be identified, rather than the average information provided by existing tools. With single molecule devices, the heterogeneity in respo ....The first generation of single entity measurement tools for analysis. The first generation of single entity measurement tools for analysis: This fellowship project aims to develop a new type of diagnostic device that measures single molecules or single cells. Such measurements seek to revolutionise analysis by allowing heterogeneity and rare events in samples to be identified, rather than the average information provided by existing tools. With single molecule devices, the heterogeneity in response enables the development of multiplexed, calibration free sensors. The outcomes of the project are hoped to be completely new thinking on performing measurements, new knowledge regarding heterogeneity in biology and the potential for novel commercialised sensors. It is expected that this will be important not only in biological discovery, but also in providing far more robust sensors for applications such as environmental monitoring, disease prediction, personalised medicine or drug discovery.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE160101101
Funder
Australian Research Council
Funding Amount
$348,741.00
Summary
Single-Molecule Circuitry for Nanoscale Electronic Devices. The aim of this project is to develop novel methods for forming robust single-molecule circuitry. The use of single molecules in electronics represents the next level of miniaturisation of electronic components, which would enable us to meet the expanding demands of modern technologies and to continue the downscaling trend in electronic devices. This project aims to address the requirements needed to translate single-molecule electronic ....Single-Molecule Circuitry for Nanoscale Electronic Devices. The aim of this project is to develop novel methods for forming robust single-molecule circuitry. The use of single molecules in electronics represents the next level of miniaturisation of electronic components, which would enable us to meet the expanding demands of modern technologies and to continue the downscaling trend in electronic devices. This project aims to address the requirements needed to translate single-molecule electronics from its current status as a fundamental tool to real-world applications. Key approaches will be the use of surface chemistry to develop new methods of wiring single molecules and the integration of robust single-molecule junctions with semiconducting electrodes. The expected project outcomes pave the way for single-molecule electronic and analytical devices.Read moreRead less
The development of tuneable materials to allow the three-dimensional printing of cells. New low cost three-dimensional (3D) printers and reagents will be developed during this project to allow cancer biologists to print cells and polymers as more realistic 3D tissue models for biological assays. Such technology will be important for performing basic research into cancers as well as for providing better tools for drug testing.
Discovery Early Career Researcher Award - Grant ID: DE160100888
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Illuminating drug activity in the brain with nanocrystalline beacons. The project focuses on developing technologies to understand the activity of drugs and precisely locate their target sites in the brain. Novel nanocrystalline beacons and ultrahigh-sensitivity optical imaging technology developed in the project have the aim to help visualise opioid and other related drug molecules over extended periods, which is impossible with current methods. Quantifying drug target distribution in the brain ....Illuminating drug activity in the brain with nanocrystalline beacons. The project focuses on developing technologies to understand the activity of drugs and precisely locate their target sites in the brain. Novel nanocrystalline beacons and ultrahigh-sensitivity optical imaging technology developed in the project have the aim to help visualise opioid and other related drug molecules over extended periods, which is impossible with current methods. Quantifying drug target distribution in the brain and imaging their dynamics on a single molecule level will shed light on drug-target interactions.Read moreRead less
Bioinks for the 3D printing of cells made from off-the-shelf components. This project aims to develop a simple method for creating complex, multiple-cell-type three-dimensional (3D) cell cultures for in-vitro cell based assays. Using 3D printing technology, this project will develop a versatile polymer system, made from entirely commercially available components, that gels upon printing and has functionality to assist cells in adhering, growing and migrating. The 3D printing of multiple cell typ ....Bioinks for the 3D printing of cells made from off-the-shelf components. This project aims to develop a simple method for creating complex, multiple-cell-type three-dimensional (3D) cell cultures for in-vitro cell based assays. Using 3D printing technology, this project will develop a versatile polymer system, made from entirely commercially available components, that gels upon printing and has functionality to assist cells in adhering, growing and migrating. The 3D printing of multiple cell types will provide biological scientists with more realistic in-vitro cell assays to those found in-vivo. Applications of the research are in cell biology, studying diseases and developing new drugs.Read moreRead less