Elimination of the transplant waiting list is the ultimate goal of research into pigto-human xenotransplantation. The prospect of success has been improved recently by refinements in technology used to introduce genetic modifications in the pig, although the genes that will need to be expressed or deleted are still undecided. What is clear is that intravascular thrombosis, a critical mediator of rejection of pig xenografts, must be overcome. This project aims to investigate the use of anticoagul ....Elimination of the transplant waiting list is the ultimate goal of research into pigto-human xenotransplantation. The prospect of success has been improved recently by refinements in technology used to introduce genetic modifications in the pig, although the genes that will need to be expressed or deleted are still undecided. What is clear is that intravascular thrombosis, a critical mediator of rejection of pig xenografts, must be overcome. This project aims to investigate the use of anticoagulant gene expression to prevent intravascular thrombosis associated with xenograft rejection.Read moreRead less