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Dietary And Environmental Risk Factors For Breast Cancer: Role Of Epigenetics
Funder
National Health and Medical Research Council
Funding Amount
$339,839.00
Summary
As part of our western diet, Australians are exposed to a high level of dietary fats. Through our heavy use of plastics, the chemical BPA used in its manufacture is also highly present in the population. This research seeks to understand the effects these factors have on the breast cancer risk in our future generations. This knowledge will help lower the number of breast cancer cases through greater public awareness of risks associated with their lifestyle choices.
Antioxidant Enzymes Counter Reactive Oxygen Species From Steroidogenic Cytochrome P450 Enzymes In The Ovary To Limit Aneuploidy Of Embryos
Funder
National Health and Medical Research Council
Funding Amount
$536,978.00
Summary
Many birth defects are due to damage sustained by the eggs before ovulation. Aging allows more damage, hence the advice to have babies earlier in life. However, we believe we have identified a source of damage that happens during late development of the follicle in the weeks before ovulation. Proving this will enable us define when an egg is most at risk of damage and to devise strategies to lower the risk.
Investigation Of Steroidogenesis As A Mechanism Of Castration Resistance In Human Prostate Cancer
Funder
National Health and Medical Research Council
Funding Amount
$419,076.00
Summary
Prostate cancer is critically dependent upon continued testosterone stimulation, even when the disease becomes resistant to existing hormonal therapies that suppress serum levels. The source of this testosterone is currently unclear. This study aims to identify the site of testosterone synthesis in patients with prostate cancer, and determine the relevance of continued testosterone signalling in patients treated with 'super castrating' hormonal therapy.