Photoreversible hydrogels to study stem cell memory and fate. This project will develop materials whose stiffness can be reversibly increased and decreased by the simple application of light, and use these to build knowledge of how stem cell fate is regulated. The influence of mechanical cues on the structure and organisation of the nucleus will be determined. Expected outcomes are new synthetic and light-reversible culture materials, and fundamental insights into how forces change the nucleus t ....Photoreversible hydrogels to study stem cell memory and fate. This project will develop materials whose stiffness can be reversibly increased and decreased by the simple application of light, and use these to build knowledge of how stem cell fate is regulated. The influence of mechanical cues on the structure and organisation of the nucleus will be determined. Expected outcomes are new synthetic and light-reversible culture materials, and fundamental insights into how forces change the nucleus to alter stem cell aging and fate. The findings will provide critical information required for the future development of assays to measure cell potency and instructive biomaterials to drive stem cell expansion and tissue-regeneration and will have impact by underpinning future advances in stem cell technologies.Read moreRead less
Micro/nano smart surfaces to unlock the potential of multipotent stem cells. This project aims to determine the interplay of micro/nanostructures on stem cell mechanotransduction and to control the cellular environment. It is expected that this will expand our knowledge on how to control stem cell fate. Expected outcomes are novel scalable technologies for micro/nanostructures and smart surfaces, controlled stem-cell expansion and differentiation, and the creation of a library of protein express ....Micro/nano smart surfaces to unlock the potential of multipotent stem cells. This project aims to determine the interplay of micro/nanostructures on stem cell mechanotransduction and to control the cellular environment. It is expected that this will expand our knowledge on how to control stem cell fate. Expected outcomes are novel scalable technologies for micro/nanostructures and smart surfaces, controlled stem-cell expansion and differentiation, and the creation of a library of protein expression based on the cell interactions. These outcomes will provide critical information required for the future development of instructive biomaterials to drive stem cell expansion and tissue-regeneration. Those materials should benefit the future development of efficient and cost-effective regenerative medicine solutions.Read moreRead less
Controlling the adhesome to regulate cell fate on biomaterials. Mesenchymal stem cell-based tissue engineering practices are hampered worldwide by the lack of appreciation and understanding of the matrix-mediated cues that must be provided during adhesion and spreading to drive cells to definitive tissue end points. This project will address these knowledge deficiencies by combining high throughput array technologies, a set of tailorable self-assembling biomaterials and real-time biosensors to r ....Controlling the adhesome to regulate cell fate on biomaterials. Mesenchymal stem cell-based tissue engineering practices are hampered worldwide by the lack of appreciation and understanding of the matrix-mediated cues that must be provided during adhesion and spreading to drive cells to definitive tissue end points. This project will address these knowledge deficiencies by combining high throughput array technologies, a set of tailorable self-assembling biomaterials and real-time biosensors to rapidly, at high resolution, elucidate how mechanotransductive cues determine the fate choice of mesenchymal stem cells, and furthermore, how to manipulate them with smart biomaterial design to achieve desired outcomes for tissue engineering. Read moreRead less
Generating multi-component scaffolding to influence the differentiation of embryonic stem cells. Nervous system diseases are debilitating and will develop in over 50 per cent of people at some time in their life. This project will develop strategies so that stem cells can be utilised to encourage brain repair for the treatment of Parkinson's disease. The technology developed will also be of benefit for the treatment of other nervous system disorders.
Engineering the Microstructure of Electrodes for Advanced Fuel Cells. A polymer solution-based integration technique is proposed to be developed to fabricate polymer electrolyte membrane fuel cells, allowing for effective engineering of the porous networks and interfaces within electrodes and cells. This novel systems materials engineering approach is expected to overcome the drawbacks of the conventional hot pressing method, enabling precise integration of nanostructured electrodes and membrane ....Engineering the Microstructure of Electrodes for Advanced Fuel Cells. A polymer solution-based integration technique is proposed to be developed to fabricate polymer electrolyte membrane fuel cells, allowing for effective engineering of the porous networks and interfaces within electrodes and cells. This novel systems materials engineering approach is expected to overcome the drawbacks of the conventional hot pressing method, enabling precise integration of nanostructured electrodes and membrane into high-performance, flexible fuel cells. The outcomes of this research aim to provide a unique opportunity for Australia to become a world leader in the rapidly-emerging clean energy technology, and critical manufacturing of new energy generation systems for domestic uses and exports, thereby producing important economic benefits.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE210101129
Funder
Australian Research Council
Funding Amount
$425,948.00
Summary
Two-Dimensional Material Tandem Detectors for Polarimetry and Spectroscopy. The aim of this project is to leverage the fundamental advantages that two-dimensional (2D) materials could provide to vertically-stacked (tandem) photodetectors. The strong absorption, tunable bandgap and polarisation dependence that many 2D materials exhibit, provides a means by which to detect properties of light. This topic is significant because it could overcome current cost/performance issues of tandem detectors, .... Two-Dimensional Material Tandem Detectors for Polarimetry and Spectroscopy. The aim of this project is to leverage the fundamental advantages that two-dimensional (2D) materials could provide to vertically-stacked (tandem) photodetectors. The strong absorption, tunable bandgap and polarisation dependence that many 2D materials exhibit, provides a means by which to detect properties of light. This topic is significant because it could overcome current cost/performance issues of tandem detectors, enabling widespread usage. The expected project outcome is the development of a novel tandem 2D detector, which as a single detector/pixel, can extract the intensity, polarisation and wavelength region of incoming light. This would provide benefits for many future applications, including machine vision and aerial surveying.Read moreRead less
A new defect-control approach for mismatched heteroepitaxy semiconductors. This project aims to develop a new defect-control approach for silicon-germanium heteroepitaxial semiconductor systems to provide a route for high-throughput, low-cost, high-efficiency silicon tandem solar cells. Mismatched heteroepitaxy of semiconductors is of considerable interest for fabricating novel devices. However, the use of highly-mismatched heteroepitaxial semiconductors has been limited due to the high densitie ....A new defect-control approach for mismatched heteroepitaxy semiconductors. This project aims to develop a new defect-control approach for silicon-germanium heteroepitaxial semiconductor systems to provide a route for high-throughput, low-cost, high-efficiency silicon tandem solar cells. Mismatched heteroepitaxy of semiconductors is of considerable interest for fabricating novel devices. However, the use of highly-mismatched heteroepitaxial semiconductors has been limited due to the high densities of crystal defects which degrade the performance of both majority and minority carrier devices. This project aims to develop a new defect-control approach for heteroepitaxial semiconductors by continuous wavelength diode laser processing. With heteroepitaxial silicon-germanium as an example, the project will investigate the mechanism underlying defect-cleaning, optimised designs for best performance, and designs for high-efficiency tandem solar cells.Read moreRead less
Nano-optics and ultra-thin materials for an infrared spectrometer-on-a-chip. Aims: This project aims to advance optical nanoresonators and ultra-thin materials in the infrared spectral region. The project aims to use this knowledge to demonstrate an infrared spectrometer on a chip.
Significance: Infrared spectroscopy is a powerful method for identifying and study matter but is carried out using instruments that are generally large, heavy, power hungry and costly.
Expected outcomes: It is expec ....Nano-optics and ultra-thin materials for an infrared spectrometer-on-a-chip. Aims: This project aims to advance optical nanoresonators and ultra-thin materials in the infrared spectral region. The project aims to use this knowledge to demonstrate an infrared spectrometer on a chip.
Significance: Infrared spectroscopy is a powerful method for identifying and study matter but is carried out using instruments that are generally large, heavy, power hungry and costly.
Expected outcomes: It is expected that this project will generate knowledge that will allow dramatic reductions in the size, weight, power consumption and cost of infrared spectrometers.
Benefits: This should allow infrared spectrometers to be used in applications for which the size/weight/power consumption/cost of current approaches prevent their use.
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Discovery Early Career Researcher Award - Grant ID: DE220100154
Funder
Australian Research Council
Funding Amount
$426,000.00
Summary
Engineering twisted two-dimensional materials for mid-infrared detectors. This project aims to engineer twisted two-dimensional materials and develop efficient room-temperature mid-infrared detectors that sense both the intensity and polarisation of light. This project expects to generate a cost-effective, ultra-compact, and multifunctional mid-infrared optical platform with high energy conversion efficiency towards advanced sensing and imaging systems. The anticipated goal of this project is to ....Engineering twisted two-dimensional materials for mid-infrared detectors. This project aims to engineer twisted two-dimensional materials and develop efficient room-temperature mid-infrared detectors that sense both the intensity and polarisation of light. This project expects to generate a cost-effective, ultra-compact, and multifunctional mid-infrared optical platform with high energy conversion efficiency towards advanced sensing and imaging systems. The anticipated goal of this project is to deliver high value-added devices with reduced energy consumption for the electronics and photonics industries. This should provide significant economic and environmental benefits by realising technological innovations, savings in materials and energy costs, and reduced environmental impact in advanced manufacturing.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE190101501
Funder
Australian Research Council
Funding Amount
$408,000.00
Summary
Printed back electrodes enabling low-cost perovskite solar cells. This project aims to address back electrode material, a bottleneck functional material in state-of-the-art perovskite solar cells (PSCs). By engineering printable and conductive materials based on carbon and gold nanowires, the project expects to enable highly-efficient and scalable PSCs while reducing cost of materials and production. These expected outcomes are to be implemented in PSCs and their impact rigorously tested in rese ....Printed back electrodes enabling low-cost perovskite solar cells. This project aims to address back electrode material, a bottleneck functional material in state-of-the-art perovskite solar cells (PSCs). By engineering printable and conductive materials based on carbon and gold nanowires, the project expects to enable highly-efficient and scalable PSCs while reducing cost of materials and production. These expected outcomes are to be implemented in PSCs and their impact rigorously tested in research cells to large-area PSCs modules produced through industry-relevant, scalable, and low-cost printing and coating methods. This will provide significant benefits to Australian industry, from small to medium enterprises to larger utility power companies, while creating economic opportunities and enabling sustainable societies.Read moreRead less