Learning to predict polymorphism through simulation of nucleation and nanoparticle evolution. Many substances are capable of exhibiting a myriad of different structures despite having the same composition. This behaviour can have a significant impact on the production of new pharmaceuticals, since the sudden appearance of a new form can lead to instant withdrawal of the drug. By understanding how different forms grow, rather than focusing on just the stability of the product, this research will ....Learning to predict polymorphism through simulation of nucleation and nanoparticle evolution. Many substances are capable of exhibiting a myriad of different structures despite having the same composition. This behaviour can have a significant impact on the production of new pharmaceuticals, since the sudden appearance of a new form can lead to instant withdrawal of the drug. By understanding how different forms grow, rather than focusing on just the stability of the product, this research will lead to more reliable prediction of how pharmaceutical molecules might assemble. The same technology will potentially have impacts in many areas of nanoscience through improvements in efficiency, including the production of minerals, desalination and undersea gas recovery.Read moreRead less
Redefining Temperature. The international system of units, which is at the basis of every accurate measurement, requires coherent definitions for its basic units (eg. metre, second, kelvin). Unfortunately, at the moment this is not so, and a global call has gone out to redefine every basic unit in terms of fundamental constants, which are by definition the same anywhere and anytime. This project will develop a new laser-based approach to measuring temperature which can be widely deployed and us ....Redefining Temperature. The international system of units, which is at the basis of every accurate measurement, requires coherent definitions for its basic units (eg. metre, second, kelvin). Unfortunately, at the moment this is not so, and a global call has gone out to redefine every basic unit in terms of fundamental constants, which are by definition the same anywhere and anytime. This project will develop a new laser-based approach to measuring temperature which can be widely deployed and uses fundamental principles for its operation: this can bring accuracy to thermometry in industry for the first time. These outcomes will generate high-level recognition for this Australian project and provide opportunities for high level research training.Read moreRead less