Designing microarray experiments. Microarrays are powerful tools for surveying the expression levels of many thousands of genes simultaneously. They belong to the new genomics technologies which have important applications in the biological, pharmaceutical and agricultural sciences. There are many sources of uncertainty in microarray experimentation and good statistical designs are essential for ensuring that the effects of interest to scientists are accurately and precisely measured. This Pr ....Designing microarray experiments. Microarrays are powerful tools for surveying the expression levels of many thousands of genes simultaneously. They belong to the new genomics technologies which have important applications in the biological, pharmaceutical and agricultural sciences. There are many sources of uncertainty in microarray experimentation and good statistical designs are essential for ensuring that the effects of interest to scientists are accurately and precisely measured. This Project will develop novel designs for microarray experiments and focus on the advancement of topics crucial to Australia's success in technological research.
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Saddlepoint approximation, likelihood analysis and ancestral graphs for strong and weak natural selection, genetic drift and population subdivision. Building new research strength in theoretical population genetics and related statistical techniques will enhance Australia's capability in harnessing the power of post-genomic information. Sophisticated statistical techniques that make smart use of genetic data are being developed in this project. The extent to which natural selection and migrati ....Saddlepoint approximation, likelihood analysis and ancestral graphs for strong and weak natural selection, genetic drift and population subdivision. Building new research strength in theoretical population genetics and related statistical techniques will enhance Australia's capability in harnessing the power of post-genomic information. Sophisticated statistical techniques that make smart use of genetic data are being developed in this project. The extent to which natural selection and migration affect current genetic polymorphism on a population level can be quantified using these new methods. New modeling provides a rigorous foundation with which to construct inference techniques currently beyond computational approaches to the data. Assessing selective effects on genetic mutations associated with human disease will be a consequence of this new statistical methodology.Read moreRead less
Special Research Initiatives - Grant ID: SR0354716
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
Energetically Open Systems Research Network Study. Conceptual frameworks arising in the physical sciences, such as non-equilibrium statistical mechanics and thermodynamics, synergetics, chaos and dynamical systems theory, are seminal in the emerging science of complexity. This study will lay the groundwork for a network to link Australian and overseas research on these fundamental concepts, and their application within the context of entropy-producing systems vital to the long-term sustainabilit ....Energetically Open Systems Research Network Study. Conceptual frameworks arising in the physical sciences, such as non-equilibrium statistical mechanics and thermodynamics, synergetics, chaos and dynamical systems theory, are seminal in the emerging science of complexity. This study will lay the groundwork for a network to link Australian and overseas research on these fundamental concepts, and their application within the context of entropy-producing systems vital to the long-term sustainability of the earth - oceans, atmosphere, biosphere, CO2-free energy production, space and solar environment. The network would facilitate the development of young investigators and be linked into wider complex systems networks such as the CSIRO Centre for Complex Systems Science.Read moreRead less